en گياهان دارویی Medicinal Plants پژوهشی Research <div style="text-align: justify;"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Background:</span></span></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""> Male factor infertility accounts for 40-50 % of overall infertility cases. Despite medical advances, effective therapeutic options for idiopathic male infertility remain limited. <b>Objective:</b> This study aims to evaluate the clinical efficacy and safety of Laboob-e Morakab electuary (LME) - a traditional Persian polyherbal formulation - in improving semen parameters in men with idiopathic infertility. <b>Methods:</b> In a single-arm, quasi-experimental pilot study, 40 men with idiopathic male infertility received 5 g of LME orally twice daily for 3 months. Primary outcomes included sperm count, motility, morphology, and ejaculate volume, evaluated according to WHO (4th edition) guidelines at baseline and post-treatment. Statistical comparisons were performed using paired t-tests or Wilcoxon signed-rank tests. <b>Results:</b> Forty participants completed the 3-month intervention. LME administration significantly improved total sperm count, percentage of normal sperm morphology, and progressive motility (P < 0.001). Mean ejaculate volume increased significantly from baseline, and an improvement in libido was reported by 60 % (n = 24) of participants. No serious adverse events were observed. <b>Conclusion:</b> Laboob-e Morakab electuary demonstrated preliminary efficacy and safety in improving semen quality in idiopathic male infertility. Randomized, double-blind, placebo-controlled trials are warranted to confirm these findings.</span></span></div> Infertility, Male, Persian Medicine, Traditional Medicine, Semen Analysis 30 39 http://jmp.ir/browse.php?a_code=A-10-3224-2&slc_lang=en&sid=1 Maryam Taghavi Shirazi mtaghavish@yahoo.com 100319475328460050156 100319475328460050156 No Institute for Studies in Medical History, Persian and Complementary Medicine, School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran Fataneh Hashem-Dabaghian dabaghian.f@iums.ac.ir 100319475328460050157 100319475328460050157 No Institute for Studies in Medical History, Persian and Complementary Medicine, School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran Farnaz Sohrabvand fsohrabvand@yahoo.com 100319475328460050158 100319475328460050158 No Tehran University of Medical Sciences, Tehran, Iran Soodabeh Bioos so.bioos@gmail.com 100319475328460050159 100319475328460050159 No Tehran University of Medical Sciences, Tehran, Iran Amirhossein Jamshidi jamshidiam@yahoo.com 100319475328460050160 100319475328460050160 No Institute for Studies in Medical History, Persian and Complementary Medicine, School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran Atefe Talebian atefeh134_68@yahoo.com 100319475328460050161 100319475328460050161 No Tehran University of Medical Sciences, Tehran, Iran Somaye Mahroozade dr.mahroozade@gmail.com 100319475328460050162 100319475328460050162 Yes Institute for Studies in Medical History, Persian and Complementary Medicine, School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran