year 8, Issue 32 (12-2009)                   J. Med. Plants 2009, 8(32): 14-24 | Back to browse issues page

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Hajiaghaee R, Bagherzadeh Z, Zarea B, Faramarzi M, Shahverdi A. Zebra Fish: Technology for Natural Product Discovery. J. Med. Plants. 2009; 8 (32) :14-24
URL: http://jmp.ir/article-1-343-en.html
1- Department of Pharmacognosy, Institute of Medicinal Plants, ACECR
2- Zebra Fish Medical Technology Developing Center, Biotechnology Research Center, Tehran University of Medical sciences
3- Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences
4- Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences , shahverd@sina.tums.ac.ir
Abstract:   (4421 Views)
Rising challenges in the present drug discovery model are prompting Prompt a renewed interest in natural products as a source of novel, bioactive small molecules. With the current validation of zebra fish as a biomedical appropriate model for functional genomics and in vivo drug discovery, the zebra fish bioassay-guided identification of natural products may be an attractive tactic to generate new lead compounds in a number of indication regions. Here, we review recent natural product research using zebra fish and evaluate the potential of this vertebrate model as a discovery platform for the systematic identification of bioactive natural products.
Full-Text [PDF 672 kb]   (3773 Downloads)    
Type of Study: Research | Subject: Pharmacognosy & Pharmaceutics
Received: 2009/04/11 | Accepted: 2009/11/15 | Published: 2009/12/20

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