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:: Volume 4, Issue 32 (12-2009) ::
JMP 2009, 4(32): 14-24 Back to browse issues page
Zebra Fish: Technology for Natural Product Discovery
R Hajiaghaee 1, Z Bagherzadeh 2, B Zarea 3, MA Faramarzi 3, AR Shahverdi * 4
1- (Ph.D.) Department of Pharmacognosy, Institute of Medicinal Plants, ACECR
2- (B.Sc.) Zebra Fish Medical Technology Developing Center, Biotechnology Research Center, Tehran University of Medical sciences
3- (Ph.D.) Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences
4- (Ph.D.) Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences , shahverd@sina.tums.ac.ir
Abstract:   (2701 Views)
Rising challenges in the present drug discovery model are prompting Prompt a renewed interest in natural products as a source of novel, bioactive small molecules. With the current validation of zebra fish as a biomedical appropriate model for functional genomics and in vivo drug discovery, the zebra fish bioassay-guided identification of natural products may be an attractive tactic to generate new lead compounds in a number of indication regions. Here, we review recent natural product research using zebra fish and evaluate the potential of this vertebrate model as a discovery platform for the systematic identification of bioactive natural products.
Keywords: Zebra fish, Danio rerio, Natural products
Full-Text [PDF 672 kb]   (945 Downloads)    
Type of Study: Research | Subject: Biotechnology
Received: 2014/10/29 | Accepted: 2014/10/29 | Published: 2014/10/29
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Hajiaghaee R, Bagherzadeh Z, Zarea B, Faramarzi M, Shahverdi A. Zebra Fish: Technology for Natural Product Discovery. JMP. 2009; 4 (32) :14-24
URL: http://jmp.ir/article-1-343-en.html


Volume 4, Issue 32 (12-2009) Back to browse issues page
فصلنامه علمی پژوهشی گیاهان دارویی Journal of Medicinal Plants
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