year 18, Issue 72 (11-2019)
J. Med. Plants 2019, 18(72): 135-148 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Farokhi S, Bahrami G, Babaie A, Farzaei M. Protective and Therapeutic Effect of Oleoresin of Pistacia atlantica in Acetic Acid-induced Colitis in Rat. J. Med. Plants 2019; 18 (72) :135-148
URL: http://jmp.ir/article-1-2709-en.html
URL: http://jmp.ir/article-1-2709-en.html
1- Students Research Committee, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran
2- Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran
3- Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran ,mh.farzaei@gmail.com
2- Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran
3- Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran ,
Abstract: (4484 Views)
Background: Ulcerative colitis is an idiopathic chronic, relapsing inflammation of the colon which is resulted from dysregulation of the mucosal immune system. In Iranian traditional medicine, oleoresin from Pistacia atlantica is used to treat gastrointestinal disorders, including peptic ulcers, dyspepsia and intestinal inflammation.
Objective: In this study, we examined the therapeutic and protective effects of oleoresin in acetic acid-induced colitis in rat.
Methods: The oleoresin was dissolved in Tween 80% (1% v / v) and doses of 100, 200 and 400 mg/kg were administered orally to animals. Three days after colitis induction, the rats were treated for 6 days and after determining the most effective dose in the treatment, the protective effect was evaluated using the optimal dose of the oleoresin for 6 days. In day 6, colitis was induced and continued for 3 days. At the end, animals were sacrificed for microscopic and macroscopic examination of colon tissues.
Results: Dose dependently, Oleoresin of P. atlantica showed therapeutic effects on microscopic and macroscopic examination of colon tissue of rats with ulcerative colitis induced by acetic acid, in comparison with control group(P<0.05). However, there was no significant difference between treatment groups and the control in the protective method (P>0.05).
Conclusion: This study showed the beneficial effects of anti-inflammatory and wound healing oleoresin of P. atlantica in acetic acid- induced ulcerative colitis in rats.
Objective: In this study, we examined the therapeutic and protective effects of oleoresin in acetic acid-induced colitis in rat.
Methods: The oleoresin was dissolved in Tween 80% (1% v / v) and doses of 100, 200 and 400 mg/kg were administered orally to animals. Three days after colitis induction, the rats were treated for 6 days and after determining the most effective dose in the treatment, the protective effect was evaluated using the optimal dose of the oleoresin for 6 days. In day 6, colitis was induced and continued for 3 days. At the end, animals were sacrificed for microscopic and macroscopic examination of colon tissues.
Results: Dose dependently, Oleoresin of P. atlantica showed therapeutic effects on microscopic and macroscopic examination of colon tissue of rats with ulcerative colitis induced by acetic acid, in comparison with control group(P<0.05). However, there was no significant difference between treatment groups and the control in the protective method (P>0.05).
Conclusion: This study showed the beneficial effects of anti-inflammatory and wound healing oleoresin of P. atlantica in acetic acid- induced ulcerative colitis in rats.
Type of Study: Research |
Subject:
Pharmacology & Toxicology
Received: 2018/06/24 | Accepted: 2018/08/21 | Published: 2019/10/28
Received: 2018/06/24 | Accepted: 2018/08/21 | Published: 2019/10/28
References
1. Minaiyan M, Karimi F and Ghannadiand Rahimi A. Anti-inflammatory effect of Pistacia atlantica subsp. kurdica volatile oil and gum on acetic acid-induced acute colitis in rat. RJP. 2015; 2 (2): 1-12.
2. Low D, Nguyen DD and Mizoguchi E. Animal models of ulcerative colitis and their application in drug research. DDDT. 2013; 7: 1341. [DOI:10.2147/DDDT.S40107]
3. Kuenzig ME, Lee SM, Eksteen B, Seow CH, Barnabe C, Panaccione R and et al. Smoking influences the need for surgery in patients with the inflammatory bowel diseases: a systematic review and meta-analysis incorporating disease duration. BMC Gastroenterol. 2016; 16 (1): 143. [DOI:10.1186/s12876-016-0555-8]
4. Felder JB, Korelitz BI, Rajapakse R, Schwarz S, Horatagis AP and Gleim G. Effects of nonsteroidal antiinflammatory drugs on inflammatory bowel disease: a case-control study. Am. J. Gastroenterol. 2000; 95 (8): 1949-54. [DOI:10.1111/j.1572-0241.2000.02262.x]
5. Levenstein S, Prantera C, Varvo V, Scribano ML, Andreoli A, Luzi C and et al. Stress and exacerbation in ulcerative colitis: a prospective study of patients enrolled in remission. Am. J. Gastroenterol. 2000; 95 (5): 1213-20. [DOI:10.1111/j.1572-0241.2000.02012.x]
6. Almeida MG, Kiss DR, Zilberstein B, Quintanilha AG, Teixeira MG and Habr-Gama A. Intestinal mucosa-associated microflora in ulcerative colitis patients before and after restorative proctocolectomy with an ileoanal pouch. Diseases of the Colon & Rectum. 2008; 51 (7): 1113. [DOI:10.1007/s10350-008-9347-8]
7. Andersson RE, Olaison G, Tysk C and Ekbom A. Appendectomy and protection against ulcerative colitis. N. Engl. J. Med. 2001; 344 (11): 808-14. [DOI:10.1056/NEJM200103153441104]
8. Rezaie A, Parker RD and Abdollahi M. Oxidative stress and pathogenesis of inflammatory bowel disease: an epiphenomenon or the cause? DDS. 2007; 52 (9): 2015-21. [DOI:10.1007/s10620-006-9622-2]
9. Baumgart DC. The diagnosis and treatment of Crohn's disease and ulcerative colitis. Dtsch. Arztebl. Int. 2009; 106 (8): 123-33. [DOI:10.3238/arztebl.2009.0123]
10. Baumgart, D.C. and W.J. Sandborn, Crohn's disease. The Lancet 2012; 380 (9853): 1590-1605. [DOI:10.1016/S0140-6736(12)60026-9]
11. Gonzalez R, Rodriguez S, Romay CH, Ancheta O, Gonzalez A, Armesto J, Remirezd and Merino N. anti-inflammatory activity of phytocianin extract in acetic acid-induced colitis in rats. Pharmacological Res. January 1999; 39 (1): 55-59. [DOI:10.1006/phrs.1998.0409]
12. Ordas I. and et al. Ulcerative colitis. Lancet 2012; 380 (9853): 1606-19. [DOI:10.1016/S0140-6736(12)60150-0]
13. Cetinkaya A, Bulbuloglu E, Kurutas EB, Ciralik H, Kantarceken B and Buyukbese MA. Beneficial Effects of N-Acetylcysteine on Acetic Acid-Induced Colitis in Rats. Tohoku J. Exp. Med. 2005; 206 (2): 131-139. [DOI:10.1620/tjem.206.131]
14. Kornbluth A and Sachar DB. Ulcerative colitis practice guidelines in adults: American college of gastroenterology, practice parameters committee. Am. J. Gastroenterol. 2010; 105 (3): 501. [DOI:10.1038/ajg.2009.727]
15. Wallace K.L. and et al. Immunopathology of inflammatory bowel disease. World J. Gastroenterol: WJG, 2014; 20 (1): 6. [DOI:10.3748/wjg.v20.i1.6]
16. Travis SP. Review article: the management of mild to severe acute ulcerative colitis. Aliment Pharmacol Ther. 2004; 20 (4): 88-92. [DOI:10.1111/j.1365-2036.2004.02056.x]
17. Nikfar S, Rahimi R, Rezaie A and Abdollahi M. A meta-analysis of the efficacy of sulfasalazine in comparison with 5-aminosalicylates in the induction of improvement and maintenance of remission in patients with ulcerative colitis. Dig. Dis. Sci. 2009; 54 (6): 1157-70. [DOI:10.1007/s10620-008-0481-x]
18. Timmer A, McDonald JW and Macdonald JK. Azathioprine and 6-mercaptopurine for maintenance of remission in ulcerative colitis. Cochrane Database Syst Rev. 2007; (1): CD000478. [DOI:10.1002/14651858.CD000478.pub2]
19. Rahimi R, Nikfar S, Rezaie A and Abdollahi M. A meta-analysis of antibiotic therapy for active ulcerative colitis. Dig. Dis. Sci. 2007; 52 (11): 2920-5. [DOI:10.1007/s10620-007-9760-1]
20. Rahimi R, Nikfar S and Abdollahi M. Meta-analysis technique confirms the effectiveness of anti-TNF-alpha in the management of active ulcerative colitis when administered in combination with corticosteroids. Med. Sci. Monit. 2007; 13 (7): PI13-8.
21. Rahimi R, Nikfar S and Abdollahi M. A meta-analysis of the benefit of probiotics in maintaining remission of human ulcerative colitis: evidence for prevention of disease relapse and maintenance of remission. AMS 2008; 4: 185-190.
22. Burisch J. Occurrence, course and prognosis during the first year of disease in a European population-based inception cohort. Dan. Med. J. 2014; 61 (1): B4778-B4778.
23. Patil MV, Kandhare AD and Bhise SD. Anti - inflammatory effect of Daucus carota root on experimental colitis in rats. Int. J. Pharm. Pharm. Sci. 2012; 4 (1): 337-343.
24. Daren L, Nguyen D and Emiko Mizoguchi. "Animal models of ulcerative colitis and their application in drug research. DDDT. 2013; 7 (1): 1341-1357. [DOI:10.2147/DDDT.S40107]
25. Tanideh N, Masoumi S, Hosseinzadeh M, Safarpour AR, Erjaee H, Koohi-Hosseinabadi O and Rahimikazerooni S. Healing Effect of Pistacia atlantica Fruit Oil Extract in Acetic Acid-Induced Colitis in Rats. Iran. J. Med. Sci. 2014; 39 (6): 522-528.
26. Adegoke GA, Onasanwo SA, Eyarefe OD and Olaleye SB. Ameliorative effects of Musa spaientum peel extract on acetic acid-induced colitis in rat. JOBAZ. 2016; 77: 49-55. [DOI:10.1016/j.jobaz.2016.06.004]
27. Haghdoost F, Baradaran Mahdavi MM, Zandifar A, Sanei MH, Zolfaghari B, Javanmard SH. Pistacia atlantica Resin Has a Dose-Dependent Effect on Angiogenesis and Skin Burn Wound Healing in Rat. Evid. Based Complement. Alternat. Med. 2013; 2013. [DOI:10.1155/2013/893425]
28. Tohidi M, Khayami M, Nejati V and Meftahizade H. Evaluation of antibacterial activity and wound healing of Pistacia atlantica and Pistacia khinjuk Evaluation of antibacterial activity and wound healing of Pistacia atlantica and Pistacia khinjuk. JMPR. 9 September, 2011; 5 (17): 4310-4314.
29. Hataminia AA, Abbaspour N, Daevishzadeh R. Antioxidant activity and phenolic profile of different part of Bene (Pistacia atlantica subsp. Kurdica) fruits. Food Chem. 2014; 145: 306-311. [DOI:10.1016/j.foodchem.2013.08.031]
30. Bozorgi M, Memariani Z, Mobli M, SalehiSurmaghi MH, Shams-Ardekani MH and Rahimi R. Five Pistacia species (P. vera, P. atlantica, P. terebinthus, P. khinjuk and P. lentiscus): A Review of Their Traditional Uses, Phytochemistry, and Pharmacology. Sci. World J. 2013; 2013. [DOI:10.1155/2013/219815]
31. Taran M, Mohebali M and Esmaeli J. In vivo Efficacy of Gum Obtain Pistacia Atlantica in Experimental Treatment of Cutaneous Leishmaniasis. IJPH. 2010; 39 (1): 36-41.
32. Bachir Gh and Benali M. Antimicrobial activity determination of the gum of Pistacia atlantica Desf. oil. AJMR. 2010; 4 (23): 2457-2460.
33. Hashemnia M, Nikousefat Z and Yazdani-Rostam M. Antidiabetic effect of Pistacia atlantica and Amygdalus scoparia in streptozotocin-induced diabetic mice. Comp Clin Path. November 2015; 24 (6): 1301-1306. [DOI:10.1007/s00580-015-2068-1]
34. Shialy Z, Zarrin M, Sadeghi Nejad B and Yusef Naanaie S. In vitro antifungal properties of Pistacia atlantica and olive extracts on different fungal species. Curr. Med. Mycol. 2015; 1 (4): 40-45. [DOI:10.18869/acadpub.cmm.1.4.40]
35. Memariani Z, Sharifzadeh M, Bozorgi M, Hajimahmoodi M, Farzaei M H, Gholami M, Siavoshi F and Saniee P. Protective effect of essential oil of Pistacia atlantica Desf. on peptic ulcer: role of α-pinene. JTCM. 2017 February 15; 37 (1): 57-63. [DOI:10.1016/S0254-6272(17)30027-4]
36. Gunaseelan V, Karthikeyan AK, Jotinkumar Singh O, Meetei UD, Krishna Pramodini Devi Kh and Rita S. Effect of Ficus hispida in inflammatory bowel disease in experimental animals. IJPSR. 2015; 6 (10): 4391-4397.
37. Khodadadi A, Mirshafeie A, Eslami M, Razavi A and Hekmat K. An investigation upon the effectiveness of LVA-7220 as an immunomodulator on chronic ulcerative colities in rats. Koomesh 2003; 4 (3): 47-54.
38. Williams K.L. and et al. Enhanced survival and mucosal repair after dextran sodium sulfate– induced colitis in transgenic mice that overexpress growth hormone. Gastroenterol. 2001; 120 (4): 925-937. [DOI:10.1053/gast.2001.22470]
39. Jagtap A.G., Shirke S.S., Phadke A.S. Effect of polyherbal formulation on experimental models of inflammatory bowel diseases. J. Ethnopharmacol. 2004; 90 (2): 195-204. [DOI:10.1016/j.jep.2003.09.042]
40. Ligumsky M. and et al. Enhanced thromboxane and prostacyclin production by cultured rectal mucosa in ulcerative colitis and its inhibition by steroids and sulfasalazine. Gastroenterol. 1981; 81 (3): 444-449. [DOI:10.1016/0016-5085(81)90594-1]
41. Lobos E.A., Sharon P. and Stenson W.F. Chemotactic activity in inflammatory bowel disease. DDS. 1987; 32 (12): 1380-1388. [DOI:10.1007/BF01296664]
42. Branski D., Sharon P. and Abrahamov A. Prostaglandins in disorders of the intestinal tract: A Review. JPGN. 1986; 5 (6): 853-860. [DOI:10.1097/00005176-198611000-00005]
43. Mai G, Seow W, Pier G, McCormack J and Thong Y. Suppression of lymphocyte and neutrophil functions by Pseudomonas aeruginosa mucoid exopolysaccharide (alginate): reversal by physicochemical, alginase, and specific monoclonal antibody treatments. Infection and Immunity 1993; 61 (2): 559-64. [DOI:10.1128/IAI.61.2.559-564.1993]
44. Goyal N, Rana A, Ahlawat A, V. Bijjem KR and Kumar P. Animal models of inflammatory bowel disease. Inflammopharmacol. 2014. [DOI:10.1007/s10787-014-0207-y]
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
