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:: Volume 4, Number 36 (12-2010) ::
JMP 2010, 4(36): 43-47 Back to browse issues page
Comparative Study on Anti-Helicobacter pylori Effects of Licorice Roots Collected from Different Regions of Iran
Sh Shoeibi1, H Hajimehdipoor *2, N Rahimifard3, SH Rezazadeh4, T Hasanloo5, F Bagheri6, A Amini7
1- (Ph.D.) Department of Toxicology, Food and Drug Laboratory Research Center and Food and Drug Control Laboratories, MOH & ME
2- (Ph.D.) Traditional Medicine and Materia Medica Research Center, Shahid Beheshti University of Medical Sciences , hmehdipoor@itmrc.org
3- (Ph.D.) Department of Microbiology, Food and Drug Laboratory Research Center and Food and Drug Control Laboratories, MOH & ME
4- (Ph.D.) Institute of Medicinal Plants, ACECR
5- (Ph.D.) Department of Physiology and Proteomics, Agricultural Biotechnology Research Institute of Iran
6- (M.Sc.) Department of Microbiology, Pharmaceutical Sciences Branch, Islamic Azad University
7- (Pharm.D.) Department of Microbiology, Pharmaceutical Sciences Branch, Islamic Azad University
Abstract:   (1981 Views)
Background: Helicobacter pylori infection is common in gastrointestinal tract and lead to gastritis, peptic ulcer and finally stomach cancer. Many synthetic drugs are used to eradicate the bacteria but there are some problems in treatment due to drug resistance and frequent relapses of infection. Herbal drugs are very important in the case. Glycyrrhiza glabra is used for treatment of H. pylori infection. This plant grows in different regions of Iran, therefore, investigation of anti H. pylori effects of the plant collected from different growing area is important. Objective: The aim of this study is determination of MIC of licorice roots collected from different regions of Iran against H. pylori in order to introduce the best growing area of the plant. Methods: Roots of the plant were collected from Kerman, Kermanshah, Sirjan, Sarhadd (Fars province), Istahban (Fars province), Ghasredasht (Fars province), Najaf Abad (Isfahan province), Ganjnameh (Hamedan province), Ekbatan (Hamedan province), Mahabad, Khorram Abad and Ardabil and extracted by using ethanol 80%. MIC of each extract was determined against three clinical isolated strains of H. pylori which obtained during endoscopy procedure. Results: The results showed that susceptibilities of three clinical isolated bacteria to the licorice extracts are different. Among the studied extracts, licorice roots collected from Ardabil showed the lowest MIC (at least: 125 ppm) and all strains were almost resistant to the extract from Mahabad. Conclusion: It is concluded that drug resistance is observed in herbals just like synthetic drugs. Moreover, in order to achieve best therapeutic results, before using an herbal preparation for treatment a disorder, growing area of a medicinal herb should be considered.
Keywords: Glycyrrhiza glabra, Licorice, Helicobacter pylori, MIC
Full-Text [PDF 237 kb]   (644 Downloads)    
Type of Study: Research | Subject: Pharmacognosy
Received: 2014/10/19 | Accepted: 2014/10/19 | Published: 2014/10/19
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Shoeibi S, Hajimehdipoor H, Rahimifard N, Rezazadeh S, Hasanloo T, Bagheri F et al . Comparative Study on Anti-Helicobacter pylori Effects of Licorice Roots Collected from Different Regions of Iran. JMP. 2010; 4 (36) :43-47
URL: http://jmp.ir/article-1-243-en.html
Volume 4, Number 36 (12-2010) Back to browse issues page
فصلنامه علمی پژوهشی گیاهان دارویی Journal of Medicinal Plants
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