year 19, Issue 74 (6-2020)
J. Med. Plants 2020, 19(74): 277-294 |
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Dadkhah A, Fatemi F, Mohammadi Malayeri M R, Karvin Ashtiani M H, Mosavi Z, Naij S et al . The anti-inflammatory and antioxidant effects of Rosa damascena Mill. essential oil on the lung injury in the CLP model. J. Med. Plants 2020; 19 (74) :277-294
URL: http://jmp.ir/article-1-2402-en.html
URL: http://jmp.ir/article-1-2402-en.html
Abolfazl Dadkhah * 
1, Faezeh Fatemi2 , Mohammad Reza Mohammadi Malayeri3 , Mohammad Hassan Karvin Ashtiani4 , Zahra Mosavi5 , Sabere Naij6 , Salome Dini7
1, Faezeh Fatemi2 , Mohammad Reza Mohammadi Malayeri3 , Mohammad Hassan Karvin Ashtiani4 , Zahra Mosavi5 , Sabere Naij6 , Salome Dini7
1- Department of Medicine, Faculty of Medicine, Qom Branch, Islamic Azad University, Qom, Iran , dadkhah_bio@yahoo.com
2- Materials and Nuclear Fuel Research School, Nuclear Science and Technology Research Institute, Tehran, Iran
3- Department of Pathobiology, Faculty of Veterinary Medicine, Garmsar Branch, Islamic Azad University, Garmsar, Iran
4- Department of biology, Faculty of Sciences, Hakim Sabzevari University, Sabzevar, Iran
5- Department of Biochemistry, Faculty of Sciences, Payame-e-Noor University, Tehran, Iran
6- Faculty of Botany, Payam Noor University, Tehran, Iran
7- Young Researchers and Elite Club, Karaj Branch, Islamic Azad University, Karaj, Iran
2- Materials and Nuclear Fuel Research School, Nuclear Science and Technology Research Institute, Tehran, Iran
3- Department of Pathobiology, Faculty of Veterinary Medicine, Garmsar Branch, Islamic Azad University, Garmsar, Iran
4- Department of biology, Faculty of Sciences, Hakim Sabzevari University, Sabzevar, Iran
5- Department of Biochemistry, Faculty of Sciences, Payame-e-Noor University, Tehran, Iran
6- Faculty of Botany, Payam Noor University, Tehran, Iran
7- Young Researchers and Elite Club, Karaj Branch, Islamic Azad University, Karaj, Iran
Abstract: (3886 Views)
Background: Sepsis or infection is the second leading cause of death in people who are intensive care units. Due to the side effects of NSAIDs drugs, the use of medicinal plants with anti-inflammatory such as Rosa (R.) damascene Mill. for treating and reducing the symptoms of the inflammation has been suggested. Objective: The current study aimed to evaluate the anti-inflammatory and antioxodant activities of Rosa (R.) damascena Mill. essential oils in the lung tissue of the septic rats induced by the experimental cecal ligation and puncture (CLP) rat model. Methods: The rats were divided into 5 groups: negative control group, positive control group and treatment groups with R. damascena Mill. essential oils and indomethacin. After 24h of CLP surgery, the oxidative parameters were measured. Results: The induction of sepsis reduced the levels of glutathione (GSH), ferric reducing antioxidant power (FRAP) as well as increased the levels lipid peroxidation (LP), myeloperoxidase (MPO), prostaglandin E2 (PGE2) and cyclooxygenase-2 (COX-2), but it had no effects on glutathione S-transferase (GST). However, the treatments of rats with R. damascena Mill. essential oils have diminished the levels of biochemical parameters. Histopathological studies also demonstrated that the induction of sepsis resulted in the lung tissue damages, while these were improved by the treatment of rats with R. damascena Mill. essential oils. Conclusion: The oxidative damages of the lung tissue were induced by the sepsis and the administartionof R. damascena Mill. essential oils can be effecient in the prevention and improvement of the injuries.
Type of Study: Research |
Subject:
Medicinal Plants
Received: 2018/12/25 | Accepted: 2019/05/11 | Published: 2020/07/21
Received: 2018/12/25 | Accepted: 2019/05/11 | Published: 2020/07/21
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