سال 19، شماره 74 - ( 3-1399 )
سال 19 شماره 74 صفحات 294-277 |
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Dadkhah A, Fatemi F, Mohammadi Malayeri M R, Karvin Ashtiani M H, Mosavi Z, Naij S et al . The anti-inflammatory and antioxidant effects of Rosa damascena Mill. essential oil on the lung injury in the CLP model. J. Med. Plants 2020; 19 (74) :277-294
URL: http://jmp.ir/article-1-2402-fa.html
URL: http://jmp.ir/article-1-2402-fa.html
دادخواه ابوالفضل، فاطمی فائزه، محمدی ملایری محمدرضا، کاروین آشتیانی محمدحسن، موسوی زهرا، ناییج صابره و همکاران.. اثر ضدالتهابی و آنتی‌اکسیدانی اسانس گل محمدی Rosa damascena Mill. بر روی آسیب ریوی ناشی از مدل CLP. فصلنامه گياهان دارویی. 1399; 19 (74) :277-294
ابوالفضل دادخواه* 
1، فائزه فاطمی2 ، محمدرضا محمدی ملایری3 ، محمدحسن کاروین آشتیانی4 ، زهرا موسوی5 ، صابره ناییج6 ، سالومه دینی7
1، فائزه فاطمی2 ، محمدرضا محمدی ملایری3 ، محمدحسن کاروین آشتیانی4 ، زهرا موسوی5 ، صابره ناییج6 ، سالومه دینی7
1- گروه پزشکی، دانشکده پزشکی، واحد قم، دانشگاه آزاد اسلامی، قم، ایران ، dadkhah_bio@yahoo.com
2- پژوهشکده مواد و سوخت هسته ای، پژوهشگاه علوم و فنون هسته ای، تهران، ایران
3- گروه پاتوبیولوژی، دانشکده دامپزشکی،دانشگاه آزاد اسلامی، واحدگرمسار،گرمسار، ایران
4- دانشکده علوم پایه، دانشگاه حکیم سبزواری، سبزوار، ایران
5- دانشکده علوم پایه، دانشگاه آزاد اسلامی، واحد قم، قم، ایران
6- گروه گیاه شناسی، دانشگاه پیام نور، تهران، ایران
7- باشگاه پژوهشگران و نخبگان جوان، دانشگاه آزاد اسلامی واحد کرج، کرج، ایران
2- پژوهشکده مواد و سوخت هسته ای، پژوهشگاه علوم و فنون هسته ای، تهران، ایران
3- گروه پاتوبیولوژی، دانشکده دامپزشکی،دانشگاه آزاد اسلامی، واحدگرمسار،گرمسار، ایران
4- دانشکده علوم پایه، دانشگاه حکیم سبزواری، سبزوار، ایران
5- دانشکده علوم پایه، دانشگاه آزاد اسلامی، واحد قم، قم، ایران
6- گروه گیاه شناسی، دانشگاه پیام نور، تهران، ایران
7- باشگاه پژوهشگران و نخبگان جوان، دانشگاه آزاد اسلامی واحد کرج، کرج، ایران
چکیده: (3887 مشاهده)
مقدمه: سپسیس یا عفونت جزء دومین علت شایع مرگ و میر میان بیماران بستری در بخش‌های مراقبت‌های ویژه به شمار می‌رود. با توجه به عوارض ناشی از مصرف داروهای ضدالتهابی غیر‌استروئیدی، استفاده از گیاهان دارویی دارای خاصیت ضدالتهابی، مانند گل محمدی برای درمان و کاهش عوارض ناشی از التهاب، توصیه می‌شود. هدف: در این تحقیق اثرات ضدالتهابی و آنتی‌اکسیدانی اسانس گل محمدیRosa damascena Mill. در بافت ریه رت‌های سپتیکی شده در مدل تجربی التهابی CLP مورد ارزیابی قرار گرفت. روش بررسی: موش‌ها به پنج گروه کنترل منفی، کنترل مثبت و گروه‌های تیمار با اسانس گل محمدی و ایندومتاسین تقسیم شده و 24 ساعت پس از جراحی، پارامترهای دخیل در استرس اکسیداتیو اندازه‌گیری شدند. نتایج: سپسیس موجب کاهش FRAP و GSH و افزایش میزان LP، MPO، PGE2 و COX-2 شده، ولی بر روی GSTتأثیر معنی‌داری نداشت. اما، تیمار حیوانات با اسانس گل محمدی به صورت معنی‌داری در سطح این پارامترهای بیوشیمیایی مؤثر بوده است. همچنین، مطالعات پاتولوژی نشان می‌دهد که سپسیس منجر به ایجاد آسیب‌هایی در بافت ریه شده که این آسیب‌ها در اثر تیمار با اسانس گل محمدی کاهش یافته‌اند. نتیجه‌گیری: سپسیس موجب آسیب اکسیداتیو بافت ریه شده و استفاده از اسانس گل محمدی می‌تواند در جلوگیری و بهبود این آسیب‌ها مؤثر باشد.
نوع مطالعه: پژوهشی |
موضوع مقاله:
گياهان دارویی
دریافت: 1397/10/4 | پذیرش: 1398/2/21 | انتشار: 1399/4/31
دریافت: 1397/10/4 | پذیرش: 1398/2/21 | انتشار: 1399/4/31
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