year 19, Issue 74 (6-2020)
J. Med. Plants 2020, 19(74): 229-238 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Salari S, Shamsaddini M. The production of nanoliposomal system containing Ducrosia anethifolia (DC.) Boiss essential oil made by sonication and filtration methods. J. Med. Plants 2020; 19 (74) :229-238
URL: http://jmp.ir/article-1-2341-en.html
URL: http://jmp.ir/article-1-2341-en.html
1- Biotechnology, Shahid Bahonar University of Kerman, Kerman, Iran , shahsal93@gmail.com
2- Razi Vaccine and Serum Research Institute, Kerman, Iran
2- Razi Vaccine and Serum Research Institute, Kerman, Iran
Abstract: (2833 Views)
Background: Ducrosia anethifolia (DC.) Boiss is native to Iran and its essential oil has cytotoxic effects. Objective: Herbal Essences have limited application due to instability. In this research, nanoliposome containing Ducrosia essential oil has been studied for abundance and size distribution to enhance the essential oil stability for use in drug delivery systems. Methods: Essential oil was prepared and GC-MS were used to identify the extracted compounds. Thin-film hydration method was then used to create small liposome loaded with the extract. Nano-liposomes were made by sonication and filtration methods with molar ratios 7:3, 3:2 and ratios of 3:1 V/V Essential oil to lipid phase. Results: The results showed that size of nanoparticles made by sonication method with molar ratios of 3:2 was 39.49 to 354.4 nm with 80.7 to 19.3 % abundance and PDI of 0.856 Encapsulation Efficiency 38% and size of liposomes prepared using filtration method was 269.8 nm with 100% abundance and PDI of 0.507 with Encapsulation Efficiency 34% and results of nanoliposomes made by sonication with molar ratios of 7:3 and ratios of 3:1 was 224.4 to 5330 nm with 93 to 7 % abundance and PDI of 0.229 with Encapsulation Efficiency 46%. The size of liposomes prepared using filtration was 358.9 nm with 100% abundance and PDI of 0.286 with Encapsulation Efficiency 43.5%. Conclusion: It is important to note that the nanoliposomes produced by the sonication are smaller than filtration for use in the liposomal nanoscale system and Encapsulation Efficiency nanoliposomes made by molar ratios 7:3 was more than 3:2 molar ratios.
Keywords: Ducrosia anethifolia, Essential Oil, Gas Chromatography Coupled with Mass Spectrometer (GC-MS) Nanoliposome
Type of Study: Research |
Subject:
Medicinal Plants
Received: 2018/11/7 | Accepted: 2019/04/29 | Published: 2020/07/21
Received: 2018/11/7 | Accepted: 2019/04/29 | Published: 2020/07/21
References
1. Shahabipour S, Firuzi O and Asadollahi M. Essential oil composition and cytotoxic activity of Ducrosia anethifolia and Ducrosia flabellifolia from Iran. J. Essent. Oil Res. 2013; 25: 160-63. [DOI:10.1080/10412905.2013.773656]
2. Nedovic V, Kalusevic A, Manojlovic V, Levic S and Bugarski B. An overview of encapsulation technologies for food applications. Procedia Food Sci. 2011; 1: 1806-15. [DOI:10.1016/j.profoo.2011.09.265]
3. Pavelkova A, Kacaniova M, Horska E, Rovna K, Hleba L and Petrova J. The effect of vacuum packaging, EDTA, oregano and thyme oils on the microbiological quality of chicken's breast. Anaerobe 2014; 29: 128 -38. [DOI:10.1016/j.anaerobe.2013.09.002]
4. Burt S. Essential oils: their antibacterial properties and potential applications in foods a review. International Journal of Food Microbiol 2004; 94(3): 223-53. [DOI:10.1016/j.ijfoodmicro.2004.03.022]
5. Hosseini SF, Zandi M, Rezaei M and Farahmandghavi F. Two-step method for encapsulation of oregano essential oil in chitosan nanoparticles: preparation, characterization and in vitro release study. Carbohydr Polym. 2013; 95(1): 50-6. [DOI:10.1016/j.carbpol.2013.02.031]
6. Zasadzinski JA. Novel methods of enhanced retention in and rapid, targeted release from liposomes. Current Opinion in Colloid & Interface Science 2011; 16(3): 203-14. [DOI:10.1016/j.cocis.2010.12.004]
7. Singh K and Mezei M. Liposomal ophthalmic drug delivery system. Dihydrostreptomycin sulfate. International Journal of Pharmaceutics 1984; 19(3): 263-69. [DOI:10.1016/0378-5173(84)90056-5]
8. Minko T. New generation of liposomal drugs for cancer. Anti-cancer Agents in Medicinal Chem. 2006; 6(6): 537-52. [DOI:10.2174/187152006778699095]
9. Peer D. Nanocarriers as an emerging platform for cancer therapy. Nat. Nano. 2007; 2(12): 751-60. [DOI:10.1038/nnano.2007.387]
10. Wu G. Chapter 14 Synthesis, Characterization, and Optical Response of Gold Nanoshells Used to Trigger Release from Liposomes, in Methods in Enzymology. D. Nejat, Editor 2009; 464: 279-307. [DOI:10.1016/S0076-6879(09)64014-3]
11. Anderson LJE and et al. Optically guided controlled release from liposomes with tunable plasmonic nanobubbles. J. Controlled Release 2010; 144(2): 151-8. [DOI:10.1016/j.jconrel.2010.02.012]
12. Liu Z and et al. siRNA Delivery into Human T Cells and Primary Cells with Carbon-Nanotube Transporters. Angew. Chem. Int. Ed. Engl. 2007; 46(12): 2023-27. [DOI:10.1002/anie.200604295]
13. Arias JL. Nanotechnology and Drug Delivery. Nanoplatforms in Drug Delivery. CRC Press USA 2014, pp: 216-18. [DOI:10.1201/b17271]
14. Mozafari MR. Nanoliposomes and Their Applications in Food Nanotechnology. Journal of Liposome Res. 2008; 18(4): 309-27. [DOI:10.1080/08982100802465941]
15. Begum K, Sarker A, Shimu IJ, Chowdhury MMI and Jalil R. Characterization of Nanoemulsion Prepared from Self-emulsifying Rifampicin and its Antibacterial Effect on Staphylococcus aureus and Stap epidermidis Isolated from AcneDhaka. Uni. J. Pharm. Sci. 2016; 117-29. [DOI:10.3329/dujps.v14i2.28507]
16. Tao F, Hill LE, Peng Y and Gomes CL. Synthesis and characterization of β-cyclodextrin inclusion complexes of thymol and thyme oil for antimicrobial delivery applications. LWT-Food Sci. Technol. 2014; 59(1): 247-55. [DOI:10.1016/j.lwt.2014.05.037]
17. Trifkovic KT, Milasinovic NZ, Djordjevic B, Krusic MTK, Knezevic-Jugovic ZD, Nedovic VA and Bugarski BM. Chitosan microbeads for encapsulation of thyme (Thymus serpyllum L.) polyphenols, Carbohydr. Polym. 2014; 111: 901-7. [DOI:10.1016/j.carbpol.2014.05.053]
18. Celia C, Trapasso E, Locatelli M, Navarra M, Ventura CA, Wolfram J and et al. Anticancer activity of liposomal bergamot essential oil (BEO) on human neuroblastoma cells. Colloids Surf. B Biointerfaces. 2013; 112: 548-53. [DOI:10.1016/j.colsurfb.2013.09.017]
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
