year 10, Issue 38 (5-2011)                   J. Med. Plants 2011, 10(38): 142-147 | Back to browse issues page

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Azadmehr A, Hajiaghaee R, Rezazadeh S, Afshari A, Kiani amin M, Baradaran B et al . Evaluation of Lavandula officinalis Extract on Lymphocyte Proliferation and Tumor Necrosis Factor-alpha Production. J. Med. Plants. 2011; 10 (38) :142-147
URL: http://jmp.ir/article-1-221-en.html
1- Young Researchers Club, Tehran North Branch, Islamic Azad University
2- Department of Pharmacognosy and Pharmacy, Institute of Medicinal Plants, ACECR , rhajiaghaee@yahoo.com
3- Department of Pharmacognosy and Pharmacy, Institute of Medicinal Plants, ACECR
4- Department of Immunology, Faculty of Medicine, Qazvin University of Medical Sciences
5- Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences
Abstract:   (6096 Views)
Background: Studies have demonstrated that plant extracts have various biological effects including immunomodulatory effect. Objective: In the present study, the immunomodulatory effects of Lavandula officinalis on lymphocyte proliferation and tumor necrosis factor alpha cytokine production were investigated. Methods: [3H] - thymidine incorporation assay on stimulation of the peripheral lymphocytes with PHA and determination of tumor necrosis factor alpha production was assayed, using LISA method. Results: The herbal extract in a concentration of 50 g/ml and lesser, in the presence of mitogen increased peripheral blood lymphocytes proliferation. However, there was not significant effect in concentrations more than 50 μg/ml. Also, the extract in the concentration of higher than 50 g/ml suppressed the production of tumor necrosis factor alpha in the exposed cells. Conclusion: The extract showed immunomodulatory effect by increasing of lymphocyte proliferation in a concentration of 50 g/ml and lesser. Also, decreasing in tumor necrosis factor alpha in the concentration of more than 50 g/ml was observed. Further studies, should focus on identifying the immunomodulatory mediator of this herbal extract.
Full-Text [PDF 153 kb]   (1789 Downloads)    
Type of Study: Research | Subject: Pharmacology & Toxicology
Received: 2014/10/15 | Accepted: 2014/10/15 | Published: 2014/10/15
* Corresponding Author Address: Research Institute of Medicinal Plants, Complex of Iranian Academic Center for Education, Culture and Research (ACECR), Kavosh Boulevard, Supa Boulevard, 55th Kilometer of Tehran-Gazvin Freeway, Pouleh Kordan, Karaj, Iran, Tel: +98 – 261 - 4764010 – 1

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