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:: Volume 2, Issue 38 (10-2011) ::
J. Med. Plants 2011, 2(38): 142-147 Back to browse issues page
Evaluation of Lavandula officinalis Extract on Lymphocyte Proliferation and Tumor Necrosis Factor-alpha Production
A Azadmehr1, R Hajiaghaee *2, Sh Rezazadeh3, A Afshari4, M Kiani amin4, B Baradaran5, P Ebrahimi1
1- Young Researchers Club, Tehran North Branch, Islamic Azad University
2- Department of Pharmacognosy and Pharmacy, Institute of Medicinal Plants, ACECR , rhajiaghaee@yahoo.com
3- Department of Pharmacognosy and Pharmacy, Institute of Medicinal Plants, ACECR
4- Department of Immunology, Faculty of Medicine, Qazvin University of Medical Sciences
5- Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences
Abstract:   (5444 Views)
Background: Studies have demonstrated that plant extracts have various biological effects including immunomodulatory effect. Objective: In the present study, the immunomodulatory effects of Lavandula officinalis on lymphocyte proliferation and tumor necrosis factor alpha cytokine production were investigated. Methods: [3H] - thymidine incorporation assay on stimulation of the peripheral lymphocytes with PHA and determination of tumor necrosis factor alpha production was assayed, using LISA method. Results: The herbal extract in a concentration of 50 g/ml and lesser, in the presence of mitogen increased peripheral blood lymphocytes proliferation. However, there was not significant effect in concentrations more than 50 μg/ml. Also, the extract in the concentration of higher than 50 g/ml suppressed the production of tumor necrosis factor alpha in the exposed cells. Conclusion: The extract showed immunomodulatory effect by increasing of lymphocyte proliferation in a concentration of 50 g/ml and lesser. Also, decreasing in tumor necrosis factor alpha in the concentration of more than 50 g/ml was observed. Further studies, should focus on identifying the immunomodulatory mediator of this herbal extract.
Keywords: Lavandula officinalis, Lymphocyte proliferation, Tumor necrosis factor alpha
Full-Text [PDF 153 kb]   (1582 Downloads)    
Type of Study: Research | Subject: Pharmacognosy
Received: 2014/10/15 | Accepted: 2014/10/15 | Published: 2014/10/15
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Azadmehr A, Hajiaghaee R, Rezazadeh S, Afshari A, Kiani amin M, Baradaran B et al . Evaluation of Lavandula officinalis Extract on Lymphocyte Proliferation and Tumor Necrosis Factor-alpha Production. J. Med. Plants. 2011; 2 (38) :142-147
URL: http://jmp.ir/article-1-221-en.html


Volume 2, Issue 38 (10-2011) Back to browse issues page
فصلنامه علمی پژوهشی گیاهان دارویی Journal of Medicinal Plants
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