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:: Volume 2, Issue 42 And S9 (supplement 9 2012) ::
JMP 2012, 2(42 And S9): 216-224 Back to browse issues page
Evaluation of Analgesic Effect of Sesame Oil and Lecithin Diets in Hot Plate and Formalin Test on Aged Male Rats
H Mohamadpour Kargar * 1, M Shafahi 2, M Kesmati 3
1- M.Sc. Islamic Azad University, Damghan branch , pourkargar@yahoo.com
2- 2- Agriculture Faculty, Islamic Azad University, Azad shahr branch
3- 3- Biology Department, Science Faculty, Shahid Chamran University, Ahwaz
Abstract:   (4854 Views)

  Background : Sesame oil is applied in physiological research as a solvent. It contains unsaturated fatty acids such as linoleic acid, sesamol and lecithin. In his research effect of dietary sesame oil on pain perception was studied.

  Objective:

  Methods : N-MRI male rats (360±20 g) were used. Animals divided to two groups: 1) control group and 2) experimental group (three subgroups that ate dietary plats that contain 10% sesame oil for 28, 42 and 56 days respectively and a subgroup ate dietary plats that contain 1% lecithin). After 28, 42 and 56 days pain was evaluateded by digital hot plate and formalin test. Data was analyzed by one way ANOVA or T- test.

  Results : Hot plate test: Sesame oil diet decreased pain in the 28, 42, 56 days significantly.

  Formalin test: Sesame oil diet decreased pain only in 42 days (p<0.02) significantly in early phase. Sesame oil diet decreased pain in the 28 days (p<0.0001) and 42 days (p<0.03) and 56 days (p<0.001) significantly in late phase of formalin test and also we found significant difference between control and lecithin group (p<0.006) in late phase.

  Hot plate test: Dietary plats (10% sesame oil) decreased acute pain perception in all experimental groups (p<0.03).

Conclusion : Our data indicated that dietary sesame oil could increase pain threshold. It seems that sesame oil lecithin (as a source for acetylcholine) or unsaturated fatty acid (altered plasma membrane properties or PGs metabolism) involve in this pain threshold alternation.
Keywords: Sesame oil, Unsaturated fatty, Lecithin, Pain, Hot plate, Formalin test
Full-Text [PDF 368 kb]   (996 Downloads)    
Type of Study: Research | Subject: Biology
Received: 2014/11/17 | Accepted: 2014/11/17 | Published: 2014/11/17
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Mohamadpour Kargar H, Shafahi M, Kesmati M. Evaluation of Analgesic Effect of Sesame Oil and Lecithin Diets in Hot Plate and Formalin Test on Aged Male Rats. JMP. 2012; 2 (42) :216-224
URL: http://jmp.ir/article-1-464-en.html


Volume 2, Issue 42 And S9 (supplement 9 2012) Back to browse issues page
فصلنامه علمی پژوهشی گیاهان دارویی Journal of Medicinal Plants
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