year 22, Issue 88 (3-2024)
J. Med. Plants 2024, 22(88): 23-35 |
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Research code: 9011266028
Ethics code: IR.TUMS.TIPS.REC.1400.132
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Tofighi Z, Mohammad Jafari R, Besati M, Pirali Hamedani M, Hadjiakhoondi A, Baharipour Z, et al . Evaluation acute and sub-chronic toxicity assessments of Oleo-gum Resin of Ferula assa-foetida L. in Wistar rats. J. Med. Plants 2024; 22 (88) :23-35
URL: http://jmp.ir/article-1-3601-en.html
URL: http://jmp.ir/article-1-3601-en.html
Zahra Tofighi1 
, Razieh Mohammad Jafari2 , Masoud Besati3 , Mostafa Pirali Hamedani4 , Abbas Hadjiakhoondi1 , Zahra Baharipour5 , Ahmad Jariani4 , Zahra Moiin4 , Saeed Tavakoli6 
, Saied Goodarzi * 7
, Razieh Mohammad Jafari2 , Masoud Besati3 , Mostafa Pirali Hamedani4 , Abbas Hadjiakhoondi1 , Zahra Baharipour5 , Ahmad Jariani4 , Zahra Moiin4 , Saeed Tavakoli6 , Saied Goodarzi * 7
1- Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran & Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
2- Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran
3- Department of Medicinal Chemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Tehran, Iran
4- Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
5- School of Pharmacy, International Campus, Tehran University of Medical Sciences, Tehran, Iran
6- Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran
7- Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran ,goodarzi_s@sina.tums.ac.ir
2- Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran
3- Department of Medicinal Chemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Tehran, Iran
4- Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
5- School of Pharmacy, International Campus, Tehran University of Medical Sciences, Tehran, Iran
6- Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran
7- Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran ,
Abstract: (494 Views)
Background: Ferula assa-foetida is an herbaceous plant from Apiaceae family. Several pharmacological effects of oleo-gum resin of this plant were introduced in modern and traditional medicines such as digestive, antimicrobial, anti-diabetic, appetizing, insecticidal, and etc. Objectives: This study aimed to acute and sub-chronic toxicity of chloroform fraction of oleo-gum extract of Ferula in Wistar rats. The safety of this can guarantee its use in treatment and various industries. Methods: Rats in six groups including male and female (kept separately) at different doses (50 mg/kg, 500 mg/kg, and 2000 mg/kg) and two control groups (control and DMSO( were selected to evaluate the acute toxicity of chloroform fraction of Ferula. For 30 days, 50 mg/kg and 250 mg/kg of sample was administrated to male and female rats. Mortality, appearance and behavioral changes, food intake, the weight of rats, and hematological, biochemical variables and histopathological changes were examined. Results: Physical and behavioral changes were not observed in acute and sub-chronic toxicity conditions. Food intake significantly differed between male and female DMSO control and other groups. In biochemical variables study, only SGOT (AST) showed a significant difference from the control group (DMSO) in acute toxicity and BUN, ALP and SGOT (AST) in sub-chronic toxicity. Also, any histopathological change was observed in spleen, liver, and kidney organs. Conclusion: Oleo-gum resin of F. assa-foetida has not toxic effects, so it should be used with caution in the long term.
Type of Study: Research |
Subject:
Medicinal Plants
Received: 2024/01/9 | Accepted: 2024/05/8 | Published: 2024/03/3
Received: 2024/01/9 | Accepted: 2024/05/8 | Published: 2024/03/3
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