سال 22، شماره 85 - ( 12-1401 )                   سال 22 شماره 85 صفحات 24-1 | برگشت به فهرست نسخه ها

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Fallah Huseini H, Foroutan B, Kianbakht S. Clinical antihypertensive efficacy and safety of Iran plants: a systematic review. J. Med. Plants 2023; 22 (85) :1-24
URL: http://jmp.ir/article-1-3469-fa.html
فلاح حسینی حسن، فروتن بهزاد، کیانبخت سعید. اثربخشی و ایمنی بالینی ضد پرفشاری خون گیاهان ایران: یک مرور نظام ‎مند. فصلنامه گياهان دارویی. 1401; 22 (85) :1-24

URL: http://jmp.ir/article-1-3469-fa.html

اثربخشی و ایمنی بالینی ضد پرفشاری خون گیاهان ایران: یک مرور نظام ‎مند
حسن فلاح حسینی1 ، بهزاد فروتن2 ، سعید کیانبخت* 3
1- مرکز تحقیقات گیاهان دارویی، پژوهشکده گیاهان دارویی، جهاد دانشگاهی، کرج، ایران
2- مرکز تحقیقات بیماری‎های گرمسیری و مسری، دانشگاه علوم پزشکی ایرانشهر، ایرانشهر، ایران؛ گروه فارماکولوژی، دانشکده پزشکی، دانشگاه علوم پزشکی ایرانشهر، ایرانشهر، ایران
3- مرکز تحقیقات گیاهان دارویی، پژوهشکده گیاهان دارویی، جهاد دانشگاهی، کرج، ایران ، skianbakht@yahoo.com
چکیده:   (1973 مشاهده)
مقدمه: استفاده از گیاهان ضدپرفشاری خون یکی از راه‌های کنترل پرفشاری خون است. هدف: بررسی اثربخشی و ایمنی بالینی ضدپرفشاری خون گیاهانی که در ایران یافت می‌شوند. روش بررسی: PUBMED ،MEDLINE ،SCOPUS ، مورد Google Scholar و Google ،EBSCO ،OVID ،PROQUEST ،SCIENCE DIRECT ،EMBASE جستجو قرار گرفت و از راهنمای PRISMA تبعیت شد. کلمات مورد جستجو عبارت بودند از Iranian ،plant ،herb ، antihypertensive ،hypertension و trial controlled randomized .مقالات زبان انگلیسی که تا آخر 2022 چاپ شده استفاده شد. مطالعات برون‌تنی و حیوانی، مقاالت سردبیر و مروری استفاده نشد. کیفیت روش شناختی مطالعات با استفاده از مقیاس JADAD ارزیابی شد. نتایج: دویست و هشت مطالعه یافت شد. فقط 74 مطالعه واجد شرایط بود. سیر (Allium sativum) (12 مطالعه)، چای ترش (Hibiscus sabdariffa)، (11 مطالعه)، چغندر (Beta vulgaris) (15 مطالعه)، گوجه فرنگی (Solanum lycopersicum)، (5 مطالعه)، دارچین (Cinnamomum verum)، (9 مطالعه)، سماق (Rhus coriaria) (1 مطالعه)، آمله (Phyllanthus emblica) (1 مطالعه)، زیتون (Olea europaea)، (4 مطالعه) و قره قاط (Vaccinium arctostaphylos) (3 مطالعه) یافت شد. اکثر مطالعات کیفیت روش شناختی بالا داشتند و اثربخشی بدون عوارض جانبی گزارش کردند. نتیجه‌گیری: درحالی‌که، اکثر مطالعات اثربخشی و ایمنی ضدپرفشاری خون نشان می‌دهند، شواهد بیشتری در رابطه با چای ترش، زیتون، قره‌قاط و سیر در مقایسه با سایر گیاهان وجود دارد.
واژه‌های کلیدی: ایران، پرفشاری خون، فشار خون، گیاه، طب مکمل، طب جایگزین
متن کامل [PDF 589 kb]   (1118 دریافت)    
نوع مطالعه: مروری | موضوع مقاله: فارماكولوژی و سم شناسی
دریافت: 1401/9/30 | پذیرش: 1401/12/2 | انتشار: 1401/12/10
فهرست منابع
1. Afzal M. Recent updates on novel therapeutic targets of cardiovascular diseases. Mol. Cell. Biochem. 2021; 476(1): 145-155. [DOI:10.1007/s11010-020-03891-8]
2. Oparil S, Acelajado MC, Bakris GL, Berlowitz DR, Cifkova R, Dominiczak AF, Grassi G, Jordan J, Poulter NR, Rodgers A and Whelton PK. Hypertension. Nat. Rev. Dis. Primers. 2018; 4: 18014. [DOI:10.1038/nrdp.2018.14]
3. Taler SJ. Initial treatment of hypertension. N. Engl. J. Med. 2018; 378(7): 636-644. [DOI:10.1056/NEJMcp1613481]
4. Volpe M, Gallo G, Battistoni A and Tocci G. Highlights of ESC/ESH 2018 guidelines on the management of hypertension: what every doctor should know. High Blood Press. Cardiovasc. Prev. 2019; 26: 1-8. [DOI:10.1007/s40292-018-00297-y]
5. Al-Makki A, DiPette D, Whelton PK, Murad MH, Mustafa RA, Acharya S, Beheiry HM, Champagne B, Connell K, Cooney MT, Ezeigwe N, Gaziano TA, Gidio A, Lopez-Jaramillo P, Khan UI, Kumarapeli V, Moran AE, Silwimba MM, Rayner B, Sukonthasan A, Yu J, Saraffzadegan N, Reddy KS and Khan T. Hypertension Pharmacological Treatment in Adults: A World Health Organization Guideline Executive Summary. Hypertension 2022; 79: 293-301. [DOI:10.1161/HYPERTENSIONAHA.121.18192]
6. Bosch A and Schmieder RE. Novel approaches to management of hypertension. Curr. Opin. Nephrol. Hypertens 2021; 30(1): 54-62. [DOI:10.1097/MNH.0000000000000668]
7. Gorostidi M and de la Sierra A. Combination therapies for hypertension - why we need to look beyond RAS blockers. Expert Rev. Clin. Pharmacol. 2018; 11(9): 841-853. [DOI:10.1080/17512433.2018.1509705]
8. Guerrero-Garcia C and Rubio-Guerra AF. Combination therapy in the treatment of hypertension. Drugs Context 2018; 7: 212531. [DOI:10.7573/dic.212531]
9. Chobanian AV. Guidelines for the management of Hypertension. Med. Clin. North Am. 2017; 101(1): 219-227. [DOI:10.1016/j.mcna.2016.08.016]
10. Verma T, Sinha M, Bansal N, Yadav SR, Shah K and Chauhan NS. Plants used as antihypertensive. Nat. Prod. Bioprospect. 2021; 11(2): 155-184. [DOI:10.1007/s13659-020-00281-x]
11. Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ and McQuay HJ. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin. Trials. 1996; 17(1): 1-12. [DOI:10.1016/0197-2456(95)00134-4]
12. Golzarand M, Ebrahimi Mamaghani M, Arefhosseini SR and Aliasgarzadeh A. Short term-effect of processed berberis consumption vulgaris on cardiovascular risk factors in type II diabetes patients with metabolic syndrome. Med. J. Tabriz Uni. Med. Sciences Health Services 2009; 31(2): 89-94.
13. SalehZadeh H, Iloun kashkooli R, Najafi SS, Hosseini Asl MK, Hamedi A and Kalateh Sadati A. The Effect of Berberis vulgaris extract on blood pressure and weight of the patients suffered from non-alcoholic fatty liver disease. J. Res. Dev. Nurs. Midw. 2013; 10(Supplementary): 21-7.
14. Zilaee M, Safarian M, Kermany T, Emamian M, Mobarhan MG and Ferns GAA. Effect of barberry treatment on blood pressure in patients with metabolic syndrome. J. Natural. Products 2015; 8: 59-63.
15. Lazavi F, Mirmiran P, Sohrab G, Nikpayam O, Angoorani P and Hedayati M. The barberry juice effects on metabolic factors and oxidative stress in patients with type 2 diabetes: a randomized clinical trial. Complement. Ther. Clin. Pract. 2018; 31: 170-174. [DOI:10.1016/j.ctcp.2018.01.009]
16. Tahmasebi L, Zakerkish M, Golfakhrabadi F and Namjoyan F. Randomised clinical trial of Berberis vulgaris root extract on glycemic and lipid parameters in type 2 diabetes mellitus patients. European J. Integrative. Medicine 2019; 32: 1000998. [DOI:10.1016/j.eujim.2019.100998]
17. Fallah Huseini H, Amini M, Mohtashami R, Ghamarchehre ME, Sadeqhi Z, Kianbakht S and Fallah Huseini A. Blood pressure lowering effect of Nigella sativa L. seed oil in healthy volunteers: a randomized, double-blind, placebo-controlled clinical trial. Phytother. Res. 2013; 27(12): 1849-53. [DOI:10.1002/ptr.4944]
18. Saumi R and Bukhari A. Phytotherapy Nigella sativa lowers blood pressure in patients with stage 1 hypertension. J. Hypertension 2015; 33(pe43). [DOI:10.1097/01.hjh.0000469884.66111.bc]
19. Badar A, Kaatabi H, Bamosa A, Al-Elq A, Abou-Hozaifa B, Lebda F, Alkhadra A and Al-Almaie S. Effect of Nigella sativa supplementation over a one-year period on lipid levels, blood pressure and heart rate in type-2 diabetic patients receiving oral hypoglycemic agents: nonrandomized clinical trial. Ann. Saudi. Med. 2017; 37(1): 56-63. [DOI:10.5144/0256-4947.2017.56]
20. Rizka A, Setiati S, Lydia A and Dewiasty E. Effect of Nigella sativa seed extract for hypertension in elderly: a double-blind, randomized controlled trial. Acta Med. Indones 2017; 49(4): 307-313.
21. Roghani Dehkordi F and Kamkhah AF. Antihypertensive effect of Nigella sativa seed extract in patients with mild hypertension. Fundam. Clin. Pharmacol. 2008; 22(4): 447-52. [DOI:10.1111/j.1472-8206.2008.00607.x]
22. Qidwai W, Hamza HB, Qureshi R and Gilani AH. Effectiveness, safety, and tolerability of powdered Nigella sativa (kalonji) seed in capsules on serum lipid levels, blood sugar, blood pressure, and body weight in adults: results of a randomized, double-blind controlled trial. J. Altern. Complement. Med. 2009; 15(6): 639-44. [DOI:10.1089/acm.2008.0367]
23. Datau EA, Wardhana, Surachmanto EE, Pandelaki K, Langi JA and Fias. Efficacy of Nigella sativa on serum free testosterone and metabolic disturbances in central obese male. Acta Med. Indones 2010; 42(3): 130-4.
24. Bin Sayeed MS, Asaduzzaman M, Morshed H, Hossain MM, Kadir MF and Rahman MR. The effect of Nigella sativa Linn. seed on memory, attention and cognition in healthy human volunteers. J. Ethnopharmacol. 2013; 148(3): 780-6. [DOI:10.1016/j.jep.2013.05.004]
25. Najmi A, Nasiruddin M, Khan RA and Haque SF. Indigenous herbal product Nigella sativa proved effective as an antihypertensive in metabolic syndrome. Asian J. Pharm. Clin. Res. 2013; 6(1): 61-64.
26. Bin Sayeed MS, Shams T, Fahim Hossain S, Rahman MR, Mostofa A, Fahim Kadir M, Mahmood S and Asaduzzaman Md. Nigella sativa L. seeds modulate mood, anxiety and cognition in healthy adolescent males. J. Ethnopharmacol. 2014; 152(1): 156-62. [DOI:10.1016/j.jep.2013.12.050]
27. Dhawan V and Jain S. Effect of garlic supplementation on oxidized low density lipoproteins and lipid peroxidation in patients of essential hypertension. Mol. Cell. Biochem. 2004; 266: 109-15. [DOI:10.1023/B:MCBI.0000049146.89059.53]
28. Turner B, Molgaard C, and Markmann P. Effect of garlic (Allium sativum) powder tablets on serum lipids, blood pressure and arterial stiffness in normo-lipidaemic volunteers; a randomised, double-blind, placebo-controlled trial. Br. J. Nutr. 2004; 92(4): 701-706. [DOI:10.1079/BJN20041255]
29. Auer W, Eiber A, Hertkorn E, Hoehfeld E, Koehrle U, Lorenz A, Mader F, Merx W, Otto G, Schmid-Otto B and et al. Hypertension and hyperlipidaemia: garlic helps in mild cases. Br. J. Clin. Pract. Suppl. 1990; 69: 3-6.
30. Sobenin IA, Andrianova IV, Demidova ON, Gorchakova T and Orekhov AN. Lipid-lowering effects of time-released garlic powder tablets in double-blinded placebo-controlled randomized study. J. Atheroscler. Thromb. 2008; 15(6): 334-8. [DOI:10.5551/jat.E550]
31. Sobenin IA, Andrianova IV, Fomchenkov IV, Gorchakova TV and Orekhov AN. Time-released garlic powder tablets lower systolic and diastolic blood pressure in men with mild and moderate arterial hypertension. Hypertens. Res. 2009; 32: 433-7. [DOI:10.1038/hr.2009.36]
32. Ashraf R, Khan RA, Ashraf I and Qureshi AA. Effects of Allium sativum (garlic) on systolic and diastolic blood pressure in patients with essential hypertension. Pak. J. Pharm. Sci. 2013; 26(5): 859-63.
33. Ried K, Frank OR and Stocks NP. Aged garlic extract lowers blood pressure in patients with treated but uncontrolled hypertension: a randomised controlled trial. Maturitas 2010; 67(2): 144-50. [DOI:10.1016/j.maturitas.2010.06.001]
34. Nakasone Y, Nakamura Y, Yamamoto T and Yamaguchi H. Effect of a traditional Japanese garlic preparation on blood pressure in prehypertensive and mildly hypertensive adults. Exp. Ther. Med. 2013; 5(2): 399-405. [DOI:10.3892/etm.2012.819]
35. Ried K, Travica N and Sali A. The effect of aged garlic extract on blood pressure and other cardiovascular risk factors in uncontrolled hypertensives: the AGE at heart trial. Integr. Blood Press Control 2016; 9: 9-21. [DOI:10.2147/IBPC.S93335]
36. Ried K, Travica N and Sali A. The Effect of kyolic aged garlic extract on gut microbiota, inflammation, and cardiovascular markers in hypertensives: the GarGIC trial. Front. Nutr. 2018; 5: 122. [DOI:10.3389/fnut.2018.00122]
37. Soleimani D, Parisa Moosavian S, Zolfaghari H and Paknahad Z. Effect of garlic powder supplementation on blood pressure and hs-C-reactive protein among nonalcoholic fatty liver disease patients: a randomized, double-blind, placebo-controlled trial. Food Sci. Nutr. 2021; 9(7): 3556-3562. [DOI:10.1002/fsn3.2307]
38. Haji Faraji M and Haji Tarkhani A. The effect of sour tea (Hibiscus sabdariffa) on essential hypertension. J. Ethnopharmacol. 1999; 65(3): 231-6. [DOI:10.1016/S0378-8741(98)00157-3]
39. Herrera-Arellano A, Flores-Romero S, Chavez-Soto MA and Tortoriello J. Effectiveness and tolerability of a standardized extract from Hibiscus sabdariffa in patients with mild to moderate hypertension: a controlled and randomized clinical trial. Phytomedicine 2004; 11(5): 375-82. [DOI:10.1016/j.phymed.2004.04.001]
40. Herrera-Arellano A, Miranda-Sanchez J, Avila-Castro P, Herrera-Alvarez S, Jimenez-Ferrer JE, Zamilpa A, Roman-Ramos R, Ponce-Monter H and Tortoriello J. Clinical effects produced by a standardized herbal medicinal product of Hibiscus sabdariffa on patients with hypertension. A randomized, double-blind, lisinopril-controlled clinical trial. Planta Med. 2007; 73(1): 6-12. [DOI:10.1055/s-2006-957065]
41. Mozaffari-Khosravi H, Jalali-Khanabadi BA, Afkhami-Ardekani M, Fatehi F and Noori-Shadkam M. The effects of sour tea (Hibiscus sabdariffa) on hypertension in patients with type II diabetes. J. Hum. Hypertens. 2009; 23: 48-54. [DOI:10.1038/jhh.2008.100]
42. Soleimani AR, Akbari H, Soleimani S, Beladi Mousavi SS and Tamadon MR. Effect of sour tea (Lipicom) pill versus captopril on the treatment of hypertension. J. Renal. Inj. Prev. 2015; 4(3): 73-9.
43. Najarzade A, Hemayati R, Zavar Reza J, Fallahzade H, Mozaffari-Khosravi H, Taghizadeh M and Esmaeili A. Effects of Hibiscus subdariffa on albuminuria and hypertension in patients with diabetic nephropathy. The J. Toloo-e-behdash. 2016; 14: 107-118.
44. McKay DL, Chen CY, Saltzman E and Blumberg JB. Hibiscus sabdariffa L. tea (tisane) lowers blood pressure in prehypertensive and mildly hypertensive adults. J. Nutr. 2010; 140(2): 298-303. [DOI:10.3945/jn.109.115097]
45. Chang HC, Peng CH, Yeh DM, Kao ES and Wang CJ. Hibiscus sabdariffa extract inhibits obesity and fat accumulation, and improves liver steatosis in humans. Food Funct. 5(4): 734-9. [DOI:10.1039/c3fo60495k]
46. Nwachukwu DC, Aneke E, Nwachukwu NZ, Obika LF, Nwagha UI and Eze AA. Effect of Hibiscus sabdariffa on blood pressure and electrolyte profile of mild to moderate hypertensive Nigerians: a comparative study with hydrochlorothiazide. Niger. J. Clin. Pract. 2015; 18(6): 762-70. [DOI:10.4103/1119-3077.163278]
47. Asgary S, Soltani R, Zolghadr M, Keshvari M and Sarrafzadegan N. Evaluation of the effects of roselle (Hibiscus sabdariffa L.) on oxidative stress and serum levels of lipids, insulin and hs-CRP in adult patients with metabolic syndrome: a double-blind placebo-controlled clinical trial. J. Complement. Integr. Med. 2016; 13(2): 175-80. [DOI:10.1515/jcim-2015-0030]
48. Kafeshani M, Entezari MH, Karimian J, Pourmasoumi M, Maracy MR, Amini MR and Hadi A. A comparative study of the effect of green tea and sour tea on blood pressure and lipid profile in healthy adult men. ARYA Atheroscler. 2017; 13(3): 109-116.
49. Bahadoran Z, Mirmiran P, Kabir A, Azizi F and Ghasemi A. (2017). The Nitrate-independent blood pressure-lowering effect of beetroot juice: a systematic review and meta-analysis. Adv. Nutr. 2017; 8(6): 830-838. [DOI:10.3945/an.117.016717]
50. Raubenheimer K, Hickey D, Leveritt M, Fassett R, Ortiz de Zevallos Munoz J, Allen JD, Briskey D, Parker TJ, Kerr G, Peake JM, Pecheniuk NM and Neubauer O. Acute effects of nitrate-rich beetroot juice on blood pressure, hemostasis and vascular inflammation markers in healthy older adults: a randomized, placebo-controlled crossover study. Nutrients 2017; 9(11): [DOI:10.3390/nu9111270]
51. Asgary S, Afshani MR, Rafieian-Kopaei M and Keshvari M. Clinical effects of consumption of raw beet juice and beet cooked on improving blood pressure, FMD and inflammatory cytokines TNF-α level of blood pressure on hypertensive patients volunteer. J. Shahrekord Univ. Med. Sci. 2017; 19(2): 148-157.
52. Ormesher L, Myers JE, Chmiel C, Wareing M, Greenwood SL, Tropea T, Lundberg JO, Weitzberg E, Nihlen C, Sibley CP, Johnstone ED, and Cottrell EC. Effects of dietary nitrate supplementation, from beetroot juice, on blood pressure in hypertensive pregnant women: a randomised, double-blind, placebo-controlled feasibility trial. Nitric Oxide 2018; 80: 37-44. [DOI:10.1016/j.niox.2018.08.004]
53. Zafeiridis A, Triantafyllou A, Papadopoulos S, Koletsos N, Touplikioti P, Zafeiridis AS, Gkaliagkousi E, Dipla K and Douma S. Dietary nitrate improves muscle microvascular reactivity and lowers blood pressure at rest and during isometric exercise in untreated hypertensives. Microcirculation 2019; 26(3): e12525. [DOI:10.1111/micc.12525]
54. Lara J, Ogbonmwan I, Oggioni C, Zheng D, Qadir O, Ashor A, Brandt K, Mathers JC and Siervo M. Effects of handgrip exercise or inorganic nitrate supplementation on 24-h ambulatory blood pressure and peripheral arterial function in overweight and obese middle age and older adults: a pilot RCT. Maturitas. 2015; 82(2): 228-35. [DOI:10.1016/j.maturitas.2015.07.028]
55. de Lima Bezerra AD, Costa EC, Pacheco DA, Souza DC, Farias-Junior LF, Ritti-Dia RM, Grigolo GB, de Bittencourt Junior PIH, Krause M, and Fayh APT. Effect of acute dietary nitrate supplementation on the post-exercise ambulatory blood pressure in obese males: a randomized, controlled, crossover trial. J. Sports Sci. Med. 2019; 18(1): 118-127.
56. Jajja A, Sutyarjoko A, Lara J, Rennie K, Brandt K, Qadir O and Siervo M. Beetroot supplementation lowers daily systolic blood pressure in older, overweight subjects. Nutr. Res. 2014; 34(10): 868-75. [DOI:10.1016/j.nutres.2014.09.007]
57. Henrohn D, Bjorkstrand K, Lundberg JO, Granstam SO, Baron T, Ingimarsdottir IJ, Hedenstrom H, Malinovschi A, Wernroth ML, Jansson M, Hedeland M and Wikstrom G. Effects of oral supplementation with nitrate-rich beetroot juice in patients with pulmonary arterial hypertension-results from BEET-PAH, an exploratory randomized, double-blind, placebo-controlled, crossover study. J. Card. Fail. 2018; 24(10): 640-653. [DOI:10.1016/j.cardfail.2018.09.010]
58. Kapil V, Khambata RS, Robertson A, Caulfield MJ Ahluwalia A. Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study. Hypertension 2015; 65(2): 320-7. [DOI:10.1161/HYPERTENSIONAHA.114.04675]
59. Siervo M, Shannon O, Kandhari N, Prabhakar M, Fostier W, Kochl C, Rogathi J, Temu G, Stephan BCM, Gray WK, Haule I, Paddick SM, Mmbaga BT and Walker R. Nitrate-rich beetroot juice reduces blood pressure in tanzanian adults with elevated blood pressure: a double-blind randomized controlled feasibility trial. J. Nutr. 2020; 150(9): 2460-2468. [DOI:10.1093/jn/nxaa170]
60. Faconti L, Mills CE, Govoni V, Gu H, Morant S, Jiang B, Cruickshank JK and Webb AJ. Cardiac effects of 6 months' dietary nitrate and spironolactone in patients with hypertension and with/at risk of type 2 diabetes, in the factorial design, double-blind, randomized controlled VaSera trial. Br. J. Clin. Pharmacol. 2019; 85(1): 169-180. [DOI:10.1111/bcp.13783]
61. Kerley CP, Dolan E, James PE and Cormican L. Dietary nitrate lowers ambulatory blood pressure in treated, uncontrolled hypertension: a 7-d, double-blind, randomised, placebo-controlled, cross-over trial. Br. J. Nutr. 2018; 119(6): 658-663. [DOI:10.1017/S0007114518000144]
62. Bondonno CP, Liu AH, Croft KD, Ward NC, Shinde S, Moodley Y, Lundberg JO, Puddey IB, Woodman RJ and Hodgson JM. Absence of an effect of high nitrate intake from beetroot juice on blood pressure in treated hypertensive individuals: a randomized controlled trial. Am. J. Clin. Nutr. 2015; 102(2): 368-75. doi: 10.3945/ajcn.114.101188. [DOI:10.3945/ajcn.114.101188]
63. Engelhard YN, Gazer B and Paran E. Natural antioxidants from tomato extract reduce blood pressure in patients with grade-1 hypertension: a double-blind, placebo-controlled pilot study. Am. Heart. J. 2006; 151(1): 100. [DOI:10.1016/j.ahj.2005.05.008]
64. Ried K, Frank OR and Stocks NP. Dark chocolate or tomato extract for prehypertension: a randomised controlled trial. BMC Complement Altern. Med. 2009; 9: 22. [DOI:10.1186/1472-6882-9-22]
65. Paran E, Novack V, Engelhard YN and Hazan-Halevy I. The effects of natural antioxidants from tomato extract in treated but uncontrolled hypertensive patients. Cardiovasc. Drugs Ther. 2009; 23: 145-51. [DOI:10.1007/s10557-008-6155-2]
66. Kim JY, Paik JK, Kim OY, Park HW, Lee JH, Jang Y and Lee JH. Effects of lycopene supplementation on oxidative stress and markers of endothelial function in healthy men. Atherosclerosis 2011; 215(1): 189-95. [DOI:10.1016/j.atherosclerosis.2010.11.036]
67. Wolak T, Sharoni Y, Levy J, Linnewiel-Hermoni K, Stepensky D and Paran E. Effect of tomato nutrient complex on blood pressure: a double blind, randomized dose(-)response study. Nutrients 2019; 11(5): 950. [DOI:10.3390/nu11050950]
68. Ziegenfuss TN, Hofheins JE, Mendel RW, Landis J and Anderson RA. Effects of a water-soluble cinnamon extract on body composition and features of the metabolic syndrome in pre-diabetic men and women. J. Int. Soc. Sports Nutr. 2006; 3(2): 45-53. [DOI:10.1186/1550-2783-3-2-45]
69. Akilen R, Tsiami A, Devendra D and Robinson N. Glycated haemoglobin and blood pressure-lowering effect of cinnamon in multi-ethnic Type 2 diabetic patients in the UK: a randomized, placebo-controlled, double-blind clinical trial. Diabet. Med. 2010; 27(10): 1159-67. [DOI:10.1111/j.1464-5491.2010.03079.x]
70. Wainstein J, Stern N, Heller S and Boaz M. Dietary cinnamon supplementation and changes in systolic blood pressure in subjects with type 2 diabetes. J. Med. Food 2011; 14(12): 1505-10. [DOI:10.1089/jmf.2010.0300]
71. Vafa MR, Mohammadi F, Shidfar F, Sormaghi MS, Heidari I, Golestan B and Amiri FS. Effects of cinnamon consumption on glycemic status, lipid profile and body composition in type 2 diabetic patients. Int. J. Prev. Med. 2012; 3(8): 531-6.
72. Anderson RA, Zhan Z, Luo R, Guo X, Guo Q, Zhou J, Kong J, Davis PA and Stoecker BJ. Cinnamon extract lowers glucose, insulin and cholesterol in people with elevated serum glucose. J. Tradit. Complement. Med .2016; 6(4), 332-336. [DOI:10.1016/j.jtcme.2015.03.005]
73. Azimi P, Ghiasvand R, Feizi A, Hosseinzadeh J, Bahreynian M, Hariri M and Khosravi-Boroujeni H. Effect of cinnamon, cardamom, saffron and ginger consumption on blood pressure and a marker of endothelial function in patients with type 2 diabetes mellitus: A randomized controlled clinical trial. Blood Press. 2016; 25(3): 133-40. [DOI:10.3109/08037051.2015.1111020]
74. Sengsuk C, Sanguanwong S, Tangvarasittichai O and Tangvarasittichai S. Effect of cinnamon supplementation on glucose, lipids levels, glomerular filtration rate, and blood pressure of subjects with type 2 diabetes mellitus. Diabetol. Int. 2016; 7: 124-132. [DOI:10.1007/s13340-015-0218-y]
75. Gupta Jain S, Puri S, Misra A, Gulati S and Mani K. Effect of oral cinnamon intervention on metabolic profile and body composition of Asian Indians with metabolic syndrome: a randomized double -blind control trial. Lipids Health Dis. 2017; 16: 113. [DOI:10.1186/s12944-017-0504-8]
76. Shishehbor F, Rezaeyan Safar M, Rajaei E and Haghighizadeh MH. Cinnamon consumption improves clinical symptoms and inflammatory markers in women with rheumatoid arthritis. J. Am. Coll. Nutr. 2018; 37(8): 685-690. [DOI:10.1080/07315724.2018.1460733]
77. Ardalani HR, Hassanpour Moghadam M, Rahimi R, Soltani J, Mozayanimonfared A, Moradie M and Azizi A. Sumac as a novel adjunctive treatment in hypertension: a randomized, double-blind, placebo-controlled clinical trial RSC Adv. 2016; 6(14): 11507-11512. [DOI:10.1039/C5RA22840A]
78. Saberi, M., Kazemisaleh D and Bolurian V. Effect of Olive Leaf on Mild to Moderate Hypertension Resistant to Normal Treatments. J. Med. Plants 2008; 7(27): 52-59.
79. Perrinjaquet-Moccetti T, Busjahn A, Schmidlin C, Schmidt A, Bradl B and Aydogan C. Food supplementation with an olive (Olea europaea L.) leaf extract reduces blood pressure in borderline hypertensive monozygotic twins. Phytother. Res. 2008; 22(9): 1239-42. [DOI:10.1002/ptr.2455]
80. Susalit E, Agus N, Effendi I, Tjandrawinata RR, Nofiarny D, Perrinjaquet-Moccetti T and Verbruggen M. Olive (Olea europaea) leaf extract effective in patients with stage-1 hypertension: comparison with Captopril. Phytomedicine 2011; 18(4): 251-8. [DOI:10.1016/j.phymed.2010.08.016]
81. Hermans MP, Lempereur P, Salembier JP, Maes N, Albert A, Jansen O and Pincemail J. Supplementation effect of a combination of Olive (Olea europea L.) leaf and fruit extracts in the clinical management of hypertension and metabolic syndrome. Antioxidants 2020; 9(9): [DOI:10.3390/antiox9090872]
82. Mohtashami R, Fallah Huseini H, Nabati F, Hajiaghaee R Kianbakht S. Effects of standardized hydro-alcoholic extract of Vaccinium arctostaphylos leaf on hypertension and biochemical parameters in hypertensive hyperlipidemic type 2 diabetic patients: a randomized, double-blind and placebo-controlled clinical trial. Avicenna J. Phytomed. 2019; 9(1): 44-53.
83. Zolfaghari F, Pourzadi N, Sahbaei F, Zolfaghari F, Kazemi SS and Davari AR. The effect of blueberry solution on blood pressure and fasting blood sugar in patients with non-insulin dependent diabetes mellitus: a double-blind clinical trial. Feyz 2015; 19(4): 278-283.
84. Kianbakht S and Hashem-Dabaghian F. Antihypertensive efficacy and safety of Vaccinium arctostaphylos berry extract in overweight/obese hypertensive patients: a randomized, double-blind and placebo-controlled clinical trial. Complement. Ther. Med. 2019; 44: 296-300. [DOI:10.1016/j.ctim.2019.05.010]
85. Ghaffari S, Navabzadeh M, Ziaee M, Ghobadi A, Ghods R and Hashem-Dabaghian F. A randomized, triple-blind, placebo-controlled, add-on clinical trial to evaluate the efficacy of Emblica officinalis in uncontrolled hypertension. Evid. Based Complement. Alternat. Med. 2020; 2020: 8592869. [DOI:10.1155/2020/8592869]
86. Carey RM, Moran AE and Whelton PK. Treatment of hypertension: a review. JAMA. 2022; 328(18): 1849-1861. [DOI:10.1001/jama.2022.19590]
87. Nadar SK and Lip GYH. Hypertension. Third ed., New York; Oxfor University Press; 2023.
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