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:: Volume 4, Number 52 (12-2014) ::
JMP 2014, 4(52): 147-153 Back to browse issues page
Isolation and Structure Elucidation of Secondary Metabolites from Aerial Part of Hippomarathrum microcarpum
AR Gohari1, I Salimikia2, R Dastjerdi3, S Saeidnia1, A Manayi1, HR Monsef Esfahani *4
1- (Ph.D.) 1- Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
2- (Ph.D. Student) 2- Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
3- (Pharm.D.) 1- Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
4- (Ph.D.) 2- Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran , irajtakmar@gmail.com
Abstract:   (3214 Views)
Background: Apiaceae family is one of the largest plant families with wide distribution all around the world. The genus Hippomarathrum has 28 species around the world which among them the species H. microcarpum outspread in the North, Northwest, West and Central of Iran, and also Turkey, Caucasus and Iraq. Objective: In this study, the main compounds in ethyl acetate extract from aerial parts of the plant Hippomarathrum microcarpum have been studied. Methods: The isolation and purification of the compounds were carried out using column chromatography. The structure of isolated compound established according 1H-NMR and 13C-NMR spectral data. Results: Two coumarins (osthole and isoimperatorin) and one sterol (β-sitosterol) have been isolated and identified from ethyl acetate extract. Conclusion: The presence of coumarines like osthole and isoimperatorin in H. microcarpum cause of the importance of this plant. This coumarines have verity of usages in traditional medicine and recent studies have supported most of these usages and revealed new effects of these coumarines. As regard that more research haven't been done about this plant and also because of significance effects of isolated coumarines, it seems necessary to perform further studies on biological effects of this plant.
Keywords: Hippomarathrum microcarpom, Isoimperatorin, Osthole, β-sitosterol
Full-Text [PDF 252 kb]   (943 Downloads)    
Type of Study: Research | Subject: Pharmacognosy
Received: 2015/01/31 | Accepted: 2015/01/31 | Published: 2015/01/31
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Gohari A, Salimikia I, Dastjerdi R, Saeidnia S, Manayi A, Monsef Esfahani H. Isolation and Structure Elucidation of Secondary Metabolites from Aerial Part of Hippomarathrum microcarpum. JMP. 2014; 4 (52) :147-153
URL: http://jmp.ir/article-1-880-en.html
Volume 4, Number 52 (12-2014) Back to browse issues page
فصلنامه علمی پژوهشی گیاهان دارویی Journal of Medicinal Plants
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