year 1, Issue 2 (5-2002)                   J. Med. Plants 2002, 1(2): 53-64 | Back to browse issues page

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Hosseinzadeh H, Karimi G, Ameri M. Anti-ulcer and acute toxicity effects of Anethum graveolens L. aerial parts extracts in mice. J. Med. Plants. 2002; 1 (2) :53-64
URL: http://jmp.ir/article-1-815-en.html
1- Pharmaceutical Sciences Research Center and School of Pharmacy, Mashhad University of Medical Sciences , hosseinzadehh@yahoo.com
2- Pharmaceutical Sciences Research Center and School of Pharmacy, Mashhad University of Medical Sciences
Abstract:   (5198 Views)
Anti-ulcer and acute toxicity effect of Anethum graveolens seed aqueous and ethanolic extracts were studied in mice. Gastric mucosal lesions were induced by oral administration of HCL (1 N) and absolute ethanol to mice. The acidity of gastric juice was measured in pyloric ligated mice. LD50 values of the aqueous and ethanolic extracts were 3.04 g/kg, i.p. (5.69, 6.16) and 6.98 g/kg, i.p. (5.69, 8.56), respectively. The efficacy of high dose of extracts (p.o.) was similar to sucralfate. The acidity was reduced by the orally or intraperitoneally administration of the extracts. The results suggest that A. graveolens seed extracts have significant antisecretory and mucosal protective effects in mice.
Full-Text [DOC 265 kb]   (2687 Downloads)    
Type of Study: Research | Subject: Pharmacology & Toxicology
Received: 2001/05/1 | Accepted: 2002/05/14 | Published: 2002/06/19

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