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:: Volume 4, Number 48 (12-2013) ::
JMP 2013, 4(48): 185-198 Back to browse issues page
Chemical Composition of the Essential Oil and Antioxidant Activities, Total Phenol and Flavonoid Content of the Extract of Nepeta pogonosperma
F Khalighi - Sigaroodi1, M Ahvazi *2, H Ebrahimzadeh3, N Rahimifard4
1- (Ph.D.) Pharmacognosy & Pharmaceutics Department of Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR
2- (M.Sc.) Cultivation & Development Department of Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR , maryame_ahvazi@yahoo.com
3- (Ph.D.) Shahid Beheshti University, Department of Chemistry, G.C
4- (Ph.D.) Food and Drug Laboratory Research Center (FDLRC), Food and Drug Control Laboratories (FDCLs), Ministry of Health (MOH)
Abstract:   (3212 Views)
Background: Nepeta pogonosperma Jamzad & Assadi (Labiatae) is one of the endemic Nepeta species in Iran (Alamut region). Flavonoids, iridoids, phenols and dierpenes have previously been reported in some Nepeta species. Genus of Nepeta have essential oil and antioxidant, antimicrobial, insecticidal, anti-inflammatory, antinociceptive and anxiolytic activities and also used in folk medicine because of their expectorant, antiseptic, antitussive, antiasthmatic and febrifuge effects. Objective: The purpose of this study was to evaluate chemical composition of the essential oil and antioxidant activities, total phenol and flavonoid content of the extract of N. pogonosperma in the flowering stage. Methods: Total phenol and flavonoid contents of the species were measured using colorimetric methods. The total antioxidant capacity was determined by the following methods: ABTS and DPPH free-radicals scavenging and ferric reducing/antioxidant power (FRAP). Essential oil was extracted by hydrodistillation and was analyzed by GC and GC/MS. Results: The extract possessed a higher concentration of total phenol than total flavonoid content. Methanol extract showed moderate DPPH scavenging activity (IC50 < 200 μg/ml). Fifty constituents were found representing 95.95% of the essential oil. The main constituents of the essential oil were 1,8-cineole and 4aα,7α,7aα-nepetalactone. Conclusion: The present results demonstrate that N. pogonosperma extract exhibits antioxidant activity and may serve as potential source of natural antioxidants for treatment of some diseases. Further investigations are necessary for chemical characterization of the active compounds and more comprehensive biological assays.
Keywords: Nepeta pogonosperma, Antioxidant activities, Essential oil composition, Iran, Labiatae
Full-Text [PDF 344 kb]   (2070 Downloads)    
Type of Study: Research | Subject: Agriculture (medicinal plants)
Received: 2014/09/30 | Accepted: 2014/09/30 | Published: 2014/09/30
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Khalighi - Sigaroodi F, Ahvazi M, Ebrahimzadeh H, Rahimifard N. Chemical Composition of the Essential Oil and Antioxidant Activities, Total Phenol and Flavonoid Content of the Extract of Nepeta pogonosperma. JMP. 2013; 4 (48) :185-198
URL: http://jmp.ir/article-1-72-en.html
Volume 4, Number 48 (12-2013) Back to browse issues page
فصلنامه علمی پژوهشی گیاهان دارویی Journal of Medicinal Plants
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