year 4, Issue 16 (12-2005)                   J. Med. Plants 2005, 4(16): 1-14 | Back to browse issues page

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Naghdi Badi H, Amin G, Makkizadeh M, Ziai S. St. John's wort (Hypericum perforatum L.): A Review. J. Med. Plants 2005; 4 (16) :1-14
1- Institute of Medicinal Plants, ACECR and Tarbiat Modarres University, Tehran, Iran ,
2- Faculty of Pharmacy, Tehran University of Medical Science (TUMS), Tehran, Iran
3- Institute of Medicinal Plants, ACECR, Tehran, Iran
Abstract:   (9065 Views)
Hypericum perforatum L., also known St. John's wort, is a herbaceous perennial belonging to Hypericaceae family that is a native of Western Europe, North Africa, and Asia. The importance of this plant as a phytopharmaceutical, especially for treatment of mild to- moderately severe depression, has significantly increased in the last few years. The major active constituents are considered to be Hypericin (a naphtodianthrone) and Hyperforin (a prenylated phloroglucinol), although other biologically active constituents eg. Flavoneids and tannins are also present. However, Hypericin is utilized as the key compound in measuring the quality of St.Johns wort and is typically used as the measure of extract potency, although recent studies indicated that hyperforin may be the antidepressive agent in St. John's wort. However, St. John's wort is one of the top- selling herbal products, which has an important place in world market.
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Type of Study: Review | Subject: Medicinal Plants
Received: 2005/01/17 | Accepted: 2005/12/31 | Published: 2006/01/21

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