year 5, Issue 20 (12-2006)                   J. Med. Plants 2006, 5(20): 27-35 | Back to browse issues page

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Hosseinzadeh H, Ramezani M, Shahsavand S. Effect of Rosmarinus officinalis L. Aerial Parts Extract and Fractions on Morphine Withdrawal Syndrome in Mice. J. Med. Plants 2006; 5 (20) :27-35
1- Corresponding author: Pharmacology and Toxicology Department, Pharmaceutical Research Center, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran ,
2- Pharmacognosy and Biotechnology Department, Pharmaceutical Research Center, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
3- Pharmacist
Abstract:   (4663 Views)
Background: Our previous studies have shown that the aqueous and ethanolic extracts of Rosmarinus officinalis L. aerial parts reduce morphine withdrawal syndrome in mice. Objective: As R. officinalis L. aerial parts total extracts reduced morphine withdrawal syndrome, we decided to evaluate the effects of rosemary extract fractions on the withdrawal syndrome. Method: Dependence was induced using subcutaneous injections of morphine daily for three days (50, 50 and 75 mg/kg). On the fourth day, morphine was injected two hours prior to the intraperitoneal injection of naloxone. The number of jumps during the 30 minute period after naloxone injection was considered as measure of the withdrawal syndrome. Results: The results indicate that the aqueous, methanolic-aqueous and chlorformic fractions (0.96 g/kg and 1.68 g/kg, i.p.) and also clonidine (0.3 mg/kg) and diazepam (5 mg/kg) reduce the number of jumps when they are injecte 1 h prior the last dose of morphine. Two evaluable MPLC chloroformic fractions also reduce the number of jumping in mice. In the open field activity, test, on the contrary of fraction 2, the fraction 1 and clonidine reduce locomotor activity. Conclusion: It is concluded that the reduction of withdrawal morphine syndrome by R. officinalis aerial parts fraction 1 may be due to the reduction of movement by this fraction, but the fraction 2 may reduce withdrawal syndrome via an interaction with opioid system.
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Type of Study: Research | Subject: Pharmacology & Toxicology
Received: 2004/06/28 | Accepted: 2005/10/16 | Published: 2007/01/21

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