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Taherian A, Etemadi H, Sadeghi H. Assessment of Aqueous Extract of Seed of Cuminum cyminum L. on Neurogenic and Inflammatory Pain in Mice. J. Med. Plants 2007; 6 (24) :44-50
URL: http://jmp.ir/article-1-553-en.html

Background: The side effects of antinoceception chemical drugs, induced notice to many medical plants (Cuminum cyminum L.) which have modulatory effect in pain. Objective: The present work investigated the effects of aqueous extract of Cuminum cyminum (CC) on neurogenic and inflamatory pain in Formalin test in mice. Methods: 50 male albino mice (20-30 gr) were used. CC (200, 500 and 1000 mg/kg) and saline were injected 30 min before formaline test. Indices of signs were licking and foot elavation for assessment of acute pain (5 min) and chronic pain (15-40 min) after injection of formaline 5% (25 µl) in paw. Results: Results indicated that CC has analgesic effect in all doses (p<0.01) but 200 mg/kg in acute phase and 1000 mg/kg in chronic phase was more effective. Conclusion: Finding showed that aqueous extract of CC can modulate acute and chronic pain. Further research is required to determine the mechanism (s) by which CC has an inhibitory effect on pain sensation.