year 8, Issue 29 And S5 (Supplement 5 2009)
J. Med. Plants 2009, 8(29 And S5): 89-96 |
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Shoeibi S, Rahimifard N, Pirouz B, Yalfani R, Pakzad S, Mirab Samiee S et al . Mutagenicity of Four Natural Flavors: Clove, Cinnamon, Thyme and Zataria multiflora Boiss.. J. Med. Plants 2009; 8 (29) :89-96
URL: http://jmp.ir/article-1-546-en.html
URL: http://jmp.ir/article-1-546-en.html
Sh Shoeibi1 
, N Rahimifard *2 , B Pirouz3 , R Yalfani4 , SR Pakzad4 , S Mirab Samiee1 , M Pirali Hamedani5
, N Rahimifard *2 , B Pirouz3 , R Yalfani4 , SR Pakzad4 , S Mirab Samiee1 , M Pirali Hamedani5
1- Food and Drug Laboratory Research center (FDLRC), Tehran, Iran
2- Food and Drug Control Laboratories (FDCLs), Ministry of Health (MOH), Tehran, Department of Medicinal Chemistry, Faculty of Pharmacy & Pharmaceutical Science Research Center, Tehran University of Medical sciences, Tehran, Iran
3- Food and Drug Control Laboratories (FDCLs), Ministry of Health (MOH), Tehran, Iran
4- Islamic Azad University, Tehran, Iran
5- Food and Drug Laboratory Research center (FDLRC), Tehran, Department of Medicinal Chemistry, Faculty of Pharmacy & Pharmaceutical Science Research Center, Tehran University of Medical sciences, Tehran, Iran
2- Food and Drug Control Laboratories (FDCLs), Ministry of Health (MOH), Tehran, Department of Medicinal Chemistry, Faculty of Pharmacy & Pharmaceutical Science Research Center, Tehran University of Medical sciences, Tehran, Iran
3- Food and Drug Control Laboratories (FDCLs), Ministry of Health (MOH), Tehran, Iran
4- Islamic Azad University, Tehran, Iran
5- Food and Drug Laboratory Research center (FDLRC), Tehran, Department of Medicinal Chemistry, Faculty of Pharmacy & Pharmaceutical Science Research Center, Tehran University of Medical sciences, Tehran, Iran
Abstract: (6149 Views)
Background: Natural flavors are widely used in various foods, cosmetic and pharmaceutical products . These kinds of additives are applied as colors, preservatives, aroma and tasting agents.
Objective: The large-scale use of certain food flavors requires accumulation of toxicological data on these substances, particularly in cases where structural similarities with other known substances showing genotoxic or carcinogenic properties indicate that some restrictions on human consumption or exposure should be implemented the case of the flavors.
Methods: In this study, Concentrations of 50, 100, 200, 300, 500, 1000 and 2000 µg/ml of four essential oils, Eugenia caryophyllata (Clove), Cinnamum zeylanicum (Cinnamon), Thymus vulgaris (Thyme) and Zataria multiflora, were tested in Salmonella typhymurium strains TA100 with and without rat liver S9 using Ames Salmonella reversion assay. Results: Without S9 fraction, increase in mutant colonies per plate was not observed in all used concentrations. Also with S9 fraction all of samples had no significant increase in mutant colonies per plate except Clove in 500 µg/ml, and higher concentrations. Conclusion: Based on obtained results, Clove oil may have mutagenic effect in 500 µg/ml and higher concentration.
Keywords: <, i>, Eugenia caryophyllata<, /i>, (Clove), <, i>, Cinnamum zeylanicum<, /i>, (Cinnamon), <, i>, Thymus vulgaris<, /i>, (Thyme), <, i>, Zataria multiflora<, /i>, Mutagenicity
Type of Study: Research |
Subject:
Pharmacognosy & Pharmaceutics
Received: 2008/06/20 | Accepted: 2009/03/12 | Published: 2009/06/21
Received: 2008/06/20 | Accepted: 2009/03/12 | Published: 2009/06/21
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