year 11, Issue 41 And S8 (supplement 8 2012)                   J. Med. Plants 2012, 11(41 And S8): 12-29 | Back to browse issues page

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Mehrafarin A, Qavami N, Naghdi Badi H, Qaderi A. Trigonelline Alkaloid, a Valuable Medicinal Metabolite Plant. J. Med. Plants. 2012; 11 (41) :12-29
1- Department of Cultivation and Development, Institute of Medicinal Plants, ACECR
2- Department of Cultivation and Development, Institute of Medicinal Plants, ACECR ,
3- Department of Biotechnology of Medicinal Plants, Institute of Medicinal Plants, ACECR
Abstract:   (11454 Views)
Trigonelline is an alkaloid composition that involved hormone role in plants. This metabolite is synthesized by methylation of nicotinic acid in plant and is found in several plants species, including coffee, fenugreek, soybean, pea, alfalfa and etc. This alkaloid is claimed to have anticarcinogenic, antimigraine, antiseptic, hypocholesterolemic, and hypoglycemic activities. Several studies has indicated that trigonelline inhibit the major enzymes of glucose metabolism thus decrease the blood glucose level. Based on this, trigonelline metabolite may be cause of a new production drug for the management and treatment of diabetes. Trigonelline was identified as a leaf-closing factor in a nyctinastic plant, a signal in the response to oxidative stress in plants, an osmoregulator in response to drought and salt stress, a molecule promoting cell arrest in G2, and an inducer of nod genes during colonization of root legumes.
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Type of Study: Review | Subject: Pharmacognosy & Pharmaceutics
Received: 2011/03/11 | Accepted: 2011/11/23 | Published: 2011/11/21

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