سال 25، شماره 97 - ( 2-1405 )
سال 25 شماره 97 صفحات 83-69 |
برگشت به فهرست نسخه ها
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Tavakkoli-Bardaskan M, Asili J, Nejad Ebrahimi S, Boozari M. Optimization of the extraction of total phenols and flavonoids from Scutellaria litwinowii: A green extraction technique based on response surface methodology and macroporous Resins. J. Med. Plants 2026; 25 (97) :69-83
URL: http://jmp.ir/article-1-3895-fa.html
URL: http://jmp.ir/article-1-3895-fa.html
Optimization of the extraction of total phenols and flavonoids from Scutellaria litwinowii: A green extraction technique based on response surface methodology and macroporous Resins. فصلنامه گياهان دارویی. 1405; 25 (97) :69-83
چکیده: (9 مشاهده)
Background: The flavonoid-rich roots of Scutellaria litwinowii have therapeutic potential, but traditional extraction methods are inefficient. This study developed an optimized protocol using modern extraction techniques to maximize extract yield. Objective: The roots of S. litwinowii contain valuable flavonoid compounds and exhibit biological properties. Response surface methodology and macroporous resins were employed to increase the extraction yield. Methods: Extraction of the plant roots was conducted according to a design optimized with Design-Expert® software. A comparative analysis was performed between reflux-assisted extraction (RAE), microwave-assisted extraction (MAE), and traditional maceration. Subsequently, phenolic and flavonoid compounds were enriched using a Diaion HP-20 resin column. Results: MAE under optimized parameters yielded a higher total phenolic content compared to conventional 72-hour maceration. Moreover, both MAE and RAE demonstrated significantly higher total flavonoid yields than the maceration method. Furthermore, the Diaion HP-20 resin column increased the amount of active compounds in the S. litwinowii extract by approximately 1.75 times. Conclusion: This study employed two principal strategies for the enrichment of phenolic and flavonoid compounds. Firstly, RAE and MAE demonstrated significantly higher efficiency compared to traditional maceration. Secondly, a purification step using a Diaion HP-20 macroporous resin column effectively concentrated the target active compounds in the final extract. The application of these novel extraction and purification methods significantly improves the quality of herbal preparations.
نوع مطالعه: پژوهشی |
موضوع مقاله:
فارماكوگنوزی و فارماسيوتيكس
دریافت: 1404/1/27 | پذیرش: 1405/2/6 | انتشار: 1405/2/16
دریافت: 1404/1/27 | پذیرش: 1405/2/6 | انتشار: 1405/2/16
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