year 25, Issue 98 (8-2026)
J. Med. Plants 2026, 25(98): 40-53 |
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Ethics code: IR.IAU.DENTAL.REC.1402.094
Clinical trials code: IRCT20231021059788N1
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Mousavikaani S M Z, Lavaf S, Alaee A. Efficacy of ginger (Zingiber officinale) alone and in combination with yarrow (Achillea millefolium) mouthwash versus Nystatin in Type II denture stomatitis: a comparative clinical trial. J. Med. Plants 2026; 25 (98) :40-53
URL: http://jmp.ir/article-1-3842-en.html
URL: http://jmp.ir/article-1-3842-en.html
1- Dentist, D.D.S. Tehran, Iran
2- Department of Prosthodontics, Faculty of Dentistry TeMS.C., Islamic Azad University, Tehran, Iran
3- The School of Medical Education and Learning Technologies, Shahid Beheshti University of Medical Sciences, Tehran, Iran ,arezoo.alaee@yahoo.com
2- Department of Prosthodontics, Faculty of Dentistry TeMS.C., Islamic Azad University, Tehran, Iran
3- The School of Medical Education and Learning Technologies, Shahid Beheshti University of Medical Sciences, Tehran, Iran ,
Abstract: (9 Views)
Background: Denture stomatitis is a common inflammatory condition in denture wearers primarily associated with Candida species. Conventional antifungal therapies are often limited by adverse side effects, high cost, and emerging drug resistance. Objective: To evaluate and compare the clinical efficacy of two herbal formulations - a ginger mouthwash and a combination ginger and yarrow mouthwash - against standard Nystatin suspension in patients with Type II denture stomatitis. Methods: In this double-blind, randomized clinical trial, 59 patients with Type II denture stomatitis were allocated to three intervention groups: ginger mouthwash, ginger–yarrow mouthwash, or Nystatin oral suspension. Palatal erythema was photographically evaluated on days 0, 7, 14, and 21. Surface area of erythema was quantified using ImageJ software. Inter- and intra-group differences were analyzed via one-way ANOVA and repeated-measures ANOVA, with statistical significance set at P < 0.05. Results: All three treatment regimens demonstrated a statistically significant reduction in palatal erythema over the 21-day period (P < 0.001). However, the Nystatin group achieved a significantly greater reduction in erythema area compared to both herbal mouthwash groups on days 7 and 14 (P < 0.05). By day 21, the difference between Nystatin and the herbal interventions was marginally significant (P = 0.054). Conclusion: While ginger and ginger–yarrow mouthwashes significantly reduce palatal inflammation, Nystatin suspension demonstrates superior speed and efficacy in the treatment of Type II denture stomatitis.
Keywords: Achillea millefolium, Candida albicans, Denture Stomatitis, Ginger, Yarrow, Zingiber officinale
Type of Study: Research |
Subject:
Pharmacognosy & Pharmaceutics
Received: 2025/02/8 | Accepted: 2026/06/28 | Published: 2026/08/29
Received: 2025/02/8 | Accepted: 2026/06/28 | Published: 2026/08/29
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