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:: Volume 4, Issue 29 (3-2009) ::
JMP 2009, 4(29): 51-57 Back to browse issues page
The Effects of Aqueous Extracts of Purtulaca oleracea on Withdrawal Syndrome in Mice
H Miladi-Gorgi * 1, AA Vafaei 2, AA Taherian 3, T Vaezi 4
1- (Ph.D. Student) Department of Physiology, Physiology Research Center, Semnan University of Medical Sciences, Semnan, Iran , miladi331@yahoo.com
2- (Ph.D.) Department of Physiology, Physiology Research Center, Semnan University of Medical Sciences, Semnan, Iran
3- (M.D.) Department of Physiology, Physiology Research Center, Semnan University of Medical Sciences, Semnan, Iran
4- (M.D.) Faculty of Medicine, Semnan University of Medical Sciences Semnan, Iran
Abstract:   (2758 Views)
Background: Purtulaca pleracea (PO) overgrows in the different parts of Iran. In previous studies, the extract of P.O showed antinociceptive, anxiolytic and anti inflammation effects in Mice and rats. Objective: This study was designed to evaluate different doses of the aqueous extracts of PO on withdrawal syndrome on mice. Methods: In this study, 40 male albino mice (25-30 gr) were used. Morphine was used to produce drug dependency by Marshall Method (10 doses of drug in four days). Different doses of the extract. (25, 50, 75 mg/kg IP) were injected to the separated groups and saline (10 ml/kg - ip) were injected to the one control group 30 min before of noloxone 2 mg/kg. The number of Jumping and amount of weight losses were used for assessment of classic withdrawal syndrome sign. Results: The results indicated that the extract of PO significantly decreased the number of Jumping (p= 0.000) and also weight losses in 25 mg doses of extract (dose-dependent) in mice (p = 0.045). Conclusion: It is concluded that the aqueous extract of PO may be play an important role on the modulation of withdrawal syndrome in mice.
Keywords: Aqueous extracts, Purtulaca oleracea, Withdrawal syndrome, Morphine, Noloxone
Full-Text [PDF 159 kb]   (934 Downloads)    
Type of Study: Research | Subject: Physiology
Received: 2014/11/5 | Accepted: 2014/11/5 | Published: 2014/11/5
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Miladi-Gorgi H, Vafaei A, Taherian A, Vaezi T. The Effects of Aqueous Extracts of Purtulaca oleracea on Withdrawal Syndrome in Mice. JMP. 2009; 4 (29) :51-57
URL: http://jmp.ir/article-1-383-en.html


Volume 4, Issue 29 (3-2009) Back to browse issues page
فصلنامه علمی پژوهشی گیاهان دارویی Journal of Medicinal Plants
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