year 24, Issue 95 (10-2025)
J. Med. Plants 2025, 24(95): 45-59 |
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Thi Thu Nguyen H, Kim Nguyen N, Thi Thu Dinh H, Vinh Trinh Q, Thi Nhu Nguyen Q, Thi Thanh Nguyen H, et al . Antidiabetic effects of Morus alba Linn leaf extract in a high-fat diet and streptozotocin-induced type 2 diabetic mouse model. J. Med. Plants 2025; 24 (95) :45-59
URL: http://jmp.ir/article-1-3774-en.html
URL: http://jmp.ir/article-1-3774-en.html
Ha Thi Thu Nguyen1 
, Ngoc Kim Nguyen1 , Hang Thi Thu Dinh2 , Quang Vinh Trinh2 , Quynh Thi Nhu Nguyen2 , Ha Thi Thanh Nguyen2 , Nam Vu3 , Nghia Trong Duong3 , Phong Xuan Pham4 , Van Anh Thi Pham *5
, Ngoc Kim Nguyen1 , Hang Thi Thu Dinh2 , Quang Vinh Trinh2 , Quynh Thi Nhu Nguyen2 , Ha Thi Thanh Nguyen2 , Nam Vu3 , Nghia Trong Duong3 , Phong Xuan Pham4 , Van Anh Thi Pham *5
1- Department of Traditional Medicine, Hanoi Medical University, Hanoi, Vietnam
2- Department of Pharmacology, Hanoi Medical University, Hanoi, Vietnam
3- Department of Traditional Medicine, National Hospital of Traditional Medicine, Hanoi, Vietnam
4- Department of Traditional Medicine, Military Institute of Traditional Medicine, Hanoi, Vietnam
5- Department of Pharmacology, Hanoi Medical University, Hanoi, Vietnam ,phamvananh@hmu.edu.vn
2- Department of Pharmacology, Hanoi Medical University, Hanoi, Vietnam
3- Department of Traditional Medicine, National Hospital of Traditional Medicine, Hanoi, Vietnam
4- Department of Traditional Medicine, Military Institute of Traditional Medicine, Hanoi, Vietnam
5- Department of Pharmacology, Hanoi Medical University, Hanoi, Vietnam ,
Abstract: (263 Views)
Background: The rising prevalence of diabetes mellitus underscores the need for safer therapeutic options, including natural products. Morus alba Linn leaf extract (MAE), a traditional remedy and the key component of the herbal product DIDALA, has been investigated for its potential antidiabetic properties. Objective: This study aimed to investigate the hypoglycemic and lipid-modulating effects of MAE in a type 2 diabetes (T2DM) experimental model induced by a high-fat diet (HFD) and streptozotocin (STZ) in mice. Methods: T2DM was induced in male Swiss mice by 8 weeks of an HFD followed by an intraperitoneal injection of STZ at 100 mg/kg. Diabetic mice were orally administered for 14 days with either a low dose MAE (0.8208 g/kg/day), a high dose MAE (2.4624 g/kg/day), or Gliclazide (80 mg/kg/day) as a positive control. Outcomes assessed included fasting blood glucose, lipid profiles (total cholesterol, LDL-cholesterol), liver and pancreatic malondialdehyde (MDA) as a marker of oxidative stress, and histological examination. Results: The low dose of MAE significantly reduced fasting blood glucose and improved lipid profile by lowering total cholesterol and LDL-cholesterol, with outcomes comparable to the Gliclazide group. It also reduced liver and pancreatic MDA levels, indicating decreased oxidative stress, and ameliorated histopathological alterations in the liver and pancreas. The high-dose MAE exerted less pronounced effects on glucose levels but still demonstrated some lipid and oxidative stress benefits. Conclusion: MAE, particularly at the lower dose, exhibits promising hypoglycemic and lipid-lowering effects in a HFD/STZ-induced T2DM mouse model, supporting its potential as a natural therapeutic candidate for diabetes management. Further studies should explore dose optimization, long-term efficacy, safety, and mechanisms of action.
Type of Study: Research |
Subject:
Pharmacognosy & Pharmaceutics
Received: 2024/11/9 | Accepted: 2025/08/9 | Published: 2025/10/2
Received: 2024/11/9 | Accepted: 2025/08/9 | Published: 2025/10/2
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