year 23, Issue 91 (8-2024)
J. Med. Plants 2024, 23(91): 75-87 |
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Research code: Grant no. 19441
Ethics code: IR.IUMS.REC.1400.783
Clinical trials code: IRCT20211201053241N1
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Akhtari E, Hashem-Dabaghian F, Jamshidi A, Fallah A, Dadmehr M. The effect of a standardized polyherbal formulation for endometriosis-associated pain: A randomized double-blind placebo-controlled clinical trial. J. Med. Plants 2024; 23 (91) :75-87
URL: http://jmp.ir/article-1-3755-en.html
URL: http://jmp.ir/article-1-3755-en.html
Elham Akhtari1 
, Fataneh Hashem-Dabaghian1 , Amirhossein Jamshidi2 , Akram Fallah3 , Majid Dadmehr *4
, Fataneh Hashem-Dabaghian1 , Amirhossein Jamshidi2 , Akram Fallah3 , Majid Dadmehr *4
1- Institute for Studies in Medical History, Persian and Complementary Medicine, Iran University of Medical Sciences, Tehran, Iran; Department of Traditional Medicine, School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran
2- Institute for Studies in Medical History, Persian and Complementary Medicine, Iran University of Medical Sciences, Tehran, Iran; Department of Traditional Pharmacy, School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran
3- Institute for Studies in Medical History, Persian and Complementary Medicine, Iran University of Medical Sciences, Tehran, Iran; Department of Traditional Medicine, School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran; Student Research Committee, Iran University of Medical Sciences, Tehran, Iran
4- Institute for Studies in Medical History, Persian and Complementary Medicine, Iran University of Medical Sciences, Tehran, Iran; Department of Traditional Medicine, School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran ,majiddadmehr@yahoo.com
2- Institute for Studies in Medical History, Persian and Complementary Medicine, Iran University of Medical Sciences, Tehran, Iran; Department of Traditional Pharmacy, School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran
3- Institute for Studies in Medical History, Persian and Complementary Medicine, Iran University of Medical Sciences, Tehran, Iran; Department of Traditional Medicine, School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran; Student Research Committee, Iran University of Medical Sciences, Tehran, Iran
4- Institute for Studies in Medical History, Persian and Complementary Medicine, Iran University of Medical Sciences, Tehran, Iran; Department of Traditional Medicine, School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran ,
Abstract: (407 Views)
Background: Dysmenorrhea, dyspareunia and endometriosis-associated pain are considered the main complications in young women with endometriosis. Proscur capsule contains several traditional herbal medicines that have shown anti-inflammatory, antioxidant, anti-androgenic, anti-estrogenic, pelvic pain reducing and analgesic effects in previous pre-clinical and clinical studies. Objective: This study aimed to investigate the clinical efficacy and safety of a standardized polyherbal formulation (proscur) for endometriosis-associated pain in young women with endometriosis. Methods: This study was a single-center, randomized, double-blinded, placebo-controlled, clinical trial. A total of 90 patients aged 20–45 years with endometriosis-associated pain were enrolled. Participants were randomly assigned to the proscur or placebo groups in a ratio of 1:1 and efficacy evaluation was conducted at day 30, 60 and 90. The participants orally administered proscur or placebo two times a day for 12 weeks. The study outcomes were measured based on a change of visual analogue scale (VAS) score and the short form endometriosis health profile questionnaire (EHP-5). Results: We observed an increase in pain relief in women who receive proscur. The serum measures of CA-125 declined in those who received proscur. Intervention was well tolerated, and no serious adverse events occurred. Conclusions: Our study showed that proscur relieved endometriosis-associated pain and CA-125 level with minimal side-effects after treatment. Therefore, proscur combined with standard medical therapy could provide more clinical benefits for patients with endometriosis-associated pain.
Type of Study: Research |
Subject:
Traditional Pharmacy & Traditional Medicine
Received: 2024/10/16 | Accepted: 2024/12/23 | Published: 2024/12/30
Received: 2024/10/16 | Accepted: 2024/12/23 | Published: 2024/12/30
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