year 24, Issue 95 (10-2025)
J. Med. Plants 2025, 24(95): 35-44 |
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Hamoonnavard S, Rezvan H, Behdarvand F, Bazargani-Gilani B, Mousavi M. In vitro anti-leishmanial activity of Boswellia sacra gum resin extract on Leishmania major promastigotes. J. Med. Plants 2025; 24 (95) :35-44
URL: http://jmp.ir/article-1-3695-en.html
URL: http://jmp.ir/article-1-3695-en.html
Sahar Hamoonnavard *1 
, Hossein Rezvan2 , Fatemeh Behdarvand2 , Behnaz Bazargani-Gilani3 , Mahshid Mousavi2
, Hossein Rezvan2 , Fatemeh Behdarvand2 , Behnaz Bazargani-Gilani3 , Mahshid Mousavi2
1- Department of Pathobiology, Faculty of Veterinary Medicine, Bu-Ali Sina University, Hamedan, Iran , s.hamoonnavard@basu.ac.ir
2- Department of Pathobiology, Faculty of Veterinary Medicine, Bu-Ali Sina University, Hamedan, Iran
3- Department of Food Hygiene and Quality Control, Faculty of Veterinary Medicine, Bu-Ali Sina University, Hamedan, Iran
2- Department of Pathobiology, Faculty of Veterinary Medicine, Bu-Ali Sina University, Hamedan, Iran
3- Department of Food Hygiene and Quality Control, Faculty of Veterinary Medicine, Bu-Ali Sina University, Hamedan, Iran
Abstract: (8 Views)
Background: The adverse effects of traditional chemical treatments have driven interest in herbal compounds for leishmaniasis therapy. Objective: This study aimed to investigate the anti-leishmanial effect of Boswellia sacra gum resin extract on the survival of Leishmania major promastigotes. Methods: Leishmania major strain (MHOM/IR/75/ER) was adjusted to 2 × 105 parasites per well. Promastigotes were exposed to a range of B. sacra gum resin extract concentrations (15, 25, 50, 70, 100, 200, 400, 800, 1600, and 3200 µg/ml) for 24 hours. Viability and cytotoxic effects were assessed using the MTT assay (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide) with absorbance measured at 450 nm. Result: The B. sacra gum resin extract reduced promastigotes viability at various concentrations, with statistically significant effects observed at 800, 1600, and 3200 µg/mL (P ≤ 0.05). Cytotoxic effects at 1600 and 3200 µg/mL were significantly greater than those at 15, 25, and 50 µg/mL (P ≤ 0.01). Conclusion: Based on the in vitro anti-leishmanial activity observed, Boswellia sacra resin extract warrants further investigation as a potential agent against cutaneous leishmaniasis. Future in vivo studies are recommended to evaluate efficacy and safety.
Type of Study: Research |
Subject:
Medicinal Plants
Received: 2024/07/6 | Accepted: 2025/08/9 | Published: 2025/10/2
Received: 2024/07/6 | Accepted: 2025/08/9 | Published: 2025/10/2
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