year 23, Issue 90 (5-2024)
J. Med. Plants 2024, 23(90): 17-30 |
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Research code: ART-3619
Ethics code: IR.SSRI.REC.1401.1604
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Roozbeh B, Mehdipoor M, Mohammad Rahimi G R, Fathei M, Clifford T, Pourmirza B. Silymarin supplementation could improve the effect of exercise training on high-fat diet-induced metabolic disorders. J. Med. Plants 2024; 23 (90) :17-30
URL: http://jmp.ir/article-1-3619-en.html
URL: http://jmp.ir/article-1-3619-en.html
Behnam Roozbeh * 
1, Mohammad Mehdipoor2 , Gholam Rasul Mohammad Rahimi3 , Mehrdad Fathei4 , Tom Clifford5 , Bibi Pourmirza6
1, Mohammad Mehdipoor2 , Gholam Rasul Mohammad Rahimi3 , Mehrdad Fathei4 , Tom Clifford5 , Bibi Pourmirza6
1- Department of Sport Sciences, Hakim Toos Higher Education Institute, Mashhad, Iran , behnam.roozbeh@hakimtoos.ac.ir
2- Department of Sport Physiology, Faculty of Sport Sciences, University of Guilan, Rasht, Iran
3- Department of Exercise Physiology, Faculty of Sports Sciences, Ferdowsi University of Mashhad, Mashhad, Iran
4- Department of Exercise Physiology, Faculty of Sports Sciences, Ferdowsi University of Mashhad, Mashhad, Iran.
5- School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK
6- Department of Sport Sciences, University of Ghadir Langroud, Langroud, Iran
2- Department of Sport Physiology, Faculty of Sport Sciences, University of Guilan, Rasht, Iran
3- Department of Exercise Physiology, Faculty of Sports Sciences, Ferdowsi University of Mashhad, Mashhad, Iran
4- Department of Exercise Physiology, Faculty of Sports Sciences, Ferdowsi University of Mashhad, Mashhad, Iran.
5- School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK
6- Department of Sport Sciences, University of Ghadir Langroud, Langroud, Iran
Abstract: (316 Views)
Background: The use of dietary herbal products as potential anti-obesity agents has gained considerable traction in recent years. Objective: The purpose of the current study was to assess the effects of silymarin supplementation with and without exercise training on a high-fat diet-induced metabolic disorder in male Wistar rats. Methods: 36 male Wistar rats were divided into six groups; 1) control group with a regular diet; 2) high-fat diet (HFD); 3) HFD + Silymarin 25 (S25); 4) HFD + Silymarin 50 (S50); 5) HFD +S25 + ART (aerobic resistance training); 6) HFD + S50+ART (n = 6 for each group). HFD + S25 + ART and HFD + S50 + ART groups performed aerobic exercise three days/week and resistance exercise two days/week. Blood specimens were obtained for biochemical assessments and gene expression at the end of the 12-week intervention. The data were analyzed using one-way ANOVAs and Tukey’s post hoc test with SPSS21 at a significance level of P < 0.05. Results: Final body weight, the levels of glucose, insulin, and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) in all of the treatment groups were significantly less compared with the HFD group (P < 0.05). Lipid profile was significantly improved in treatment groups in comparison with the HFD group (P < 0.05). Leptin and Neuropeptide Y (NPY) levels were significantly lower in HFD + S50, HFD + S25 + ART, and HFD + S50 + ART groups compared to HFD group (P < 0.05). Exercise plus silymarin consumption (HFD + S25 + ART and HFD + S50 + ART) increased Peptide YY levels (PYY) (P= 0.013 and P < 0.001, respectively). Conclusion: Our findings suggest that combined silymarin consumption and exercise training is a promising non-pharmacological treatment for multiple simultaneous HFD-induced risk factors.
Type of Study: Research |
Subject:
Medicinal Plants
Received: 2024/02/18 | Accepted: 2024/08/26 | Published: 2024/10/26
Received: 2024/02/18 | Accepted: 2024/08/26 | Published: 2024/10/26
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