year 21, Issue 83 (9-2022)                   J. Med. Plants 2022, 21(83): 1-10 | Back to browse issues page


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Dehparvar N, Alijaniha F, Mozaffarpur S A, Niasari-Naslaji A, Bahaedin Z, Garshasbi A, et al . Suggested herbal remedies effective on polycystic ovarian syndrome from the viewpoint of Persian medicine. J. Med. Plants 2022; 21 (83) :1-10
URL: http://jmp.ir/article-1-3393-en.html
1- Department of Traditional Persian Medicine, Faculty of Medicine, Shahed University, Tehran, Iran
2- Traditional Medicine Clinical Trial Research Center, Shahed University, Tehran, Iran & Department of Traditional Persian Medicine, Faculty of Medicine, Shahed University, Tehran, Iran
3- Traditional Medicine and History of Medical Sciences Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
4- Department of Theriogenology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
5- Obstetrics and Gynecology Department, Medical School, Shahed University, Tehran, Iran
6- Department of Biostatistics, Faculty of Medicine, Tarbiat Modares Univesity, Tehran, Iran
7- Traditional Medicine Clinical Trial Research Center, Shahed University, Tehran, Iran & Department of Traditional Persian Medicine, Faculty of Medicine, Shahed University, Tehran, Iran , naseri@shahed.ac.ir
Abstract:   (367 Views)
Background: According to the reverse pharmacological method, traditional medicine has a good source of information for discovering new drug candidates. Polycystic ovarian syndrome (PCOS) is the most common cause of endocrine disorder and infertility among women of reproductive age. This syndrome is commonly treated by oral contraceptive pills; however, it could be associated with side effects. Objective: The purpose of this study was to identify and prioritize medicinal plants proposed by Persian medicine (PM) for the treatment of PCOS. Methods: The first step was to find out the most relevant keywords to the symptoms of PCOS among five authentic PM manuscripts because there was no medical term called PCOS in PM texts. According to those keywords, all materia medicas that was described in the selected books were recorded. Each materia medica received scores based on specific criteria.  The scores were used to prioritize medicaments. Results: Ferula assa-foetida L., Tanacetum parthenium L., Lycium barbarum, Cymbopogon schoenanthus L., Lepidium sativum L. and Marrubium vulgare were six top materia medica identified in this study. Conclusion: Identification of closely related terminology for PCOS in traditional medical texts and prioritization of herbal remedies could be a sound approach to discover new drugs. Accordingly, Ferula assa-foetida L. with the highest score was considered the best candidate for the treatment of PCOS in PM.
Full-Text [PDF 528 kb]   (254 Downloads)    
Type of Study: Review | Subject: Medicinal Plants
Received: 2022/07/26 | Accepted: 2022/09/24 | Published: 2022/09/26

References
1. Tobinick EL. The value of drug repositioning in the current pharmaceutical market. Drug News Perspect. 2009; 22: 119-25. [DOI:10.1358/dnp.2009.22.2.1303818]
2. Patwardhan B and Vaidya AD. Natural products drug discovery: accelerating the clinical candidate development using reverse pharmacology approaches. Indian J Exp Biol. 2010; 48: 220-7.
3. Patwardhan B and Mashelkar RA. Traditional medicine-inspired approaches to drug discovery: can Ayurveda show the way forward? Drug Discov Today. 2009; 14: 804-11. [DOI:10.1016/j.drudis.2009.05.009]
4. B Aggarwal B, Prasad S, Reuter S, Kannappan R, R Yadav V, Park B, Hye Kim J, C Gupta S, Phromnoi K, Sundaram C and Prasad S. Identification of novel anti-inflammatory agents from Ayurvedic medicine for prevention of chronic diseases: "reverse pharmacology" and "bedside to bench" approach. Curr Drug Targets. 2011; 12: 1595-653. [DOI:10.2174/138945011798109464]
5. Surh YJ. Reverse pharmacology applicable for botanical drug development-inspiration from the legacy of traditional wisdom. J. Tradit. Complement Med. 2011; 1:5. [DOI:10.1016/S2225-4110(16)30051-7]
6. Ghaffari F, Naseri M, Jafari Hajati R and et al. a pioneer in contribution to trials in medical practice. Acta Medico-historica Adriatica: AMHA. 2017; 15(2): 261-70. [DOI:10.31952/amha.15.2.4]
7. Soltanian AR, Mehdibarzi D, Faghihzadeh S, Naseri M and Gerami A. Mixture of Arnebia euchroma and Matricaria chamomilla (Marhame-Mafasel) for pain relief of osteoarthritis of the knee-a two-treatment, two-period crossover trial. Arch. Med. Sci: AMS. 2010; 6:950. [DOI:10.5114/aoms.2010.19307]
8. Hajiheydari MR, Yarmohammadi ME, Izadi P, Jafari F, Emadi F, Emaratkar E, Abtahi SH, Zargaran A and Naseri M. Effect of Nepeta bracteata Benth. on allergic rhinitis symptoms: A randomized double-blind clinical trial. J. Res. Med. Sci. 2017; 22. [DOI:10.4103/jrms.JRMS_316_17]
9. Esmaeilidooki MR, Mozaffarpur SA, Mirzapour M, Shirafkan H, Kamalinejad M and Bijani A. Comparison between the cassia fistulas emulsion with polyethylene glycol (peg4000) in the pediatric functional constipation: a randomized clinical trial. Iran Red. Crescent. Med. J. 2016; 18. [DOI:10.5812/ircmj.33998]
10. Naseri V, Chavoshzadeh Z, Mizani A, Daneshfard B, Ghaffari F, Abbas‐Mohammadi M, Gachkar L, Kamalinejad M, Jafari Hajati R, Bahaeddin Z and Faghihzadeh S. Effect of topical marshmallow (Althaea officinalis) on atopic dermatitis in children: A pilot double‐blind active‐controlled clinical trial of an in‐silico‐analyzed phytomedicine. Phytother. Res. 2021; 35(3): 1389-98. [DOI:10.1002/ptr.6899]
11. Mokaberinejad R, Akhtari E, Tansaz M, Bioos S, Kamalinejad M, Zafarghandi N, Ghobadi A, Sohrabvand F and Akhbari A. Effect of mentha longifolia on fsh serum level in premature ovarian failure. Open J. Obstet. Gynecol. 2014; 4(07): 356. [DOI:10.4236/ojog.2014.47053]
12. Shahabi S, Hassan ZM, Mahdavi M, Dezfouli M, Rahvar MT, Naseri M, Jazani NH and Khalkhali HR. Hot and Cold natures and some parameters of neuroendocrine and immune systems in traditional Iranian medicine: a preliminary study. J. Altern. Complement. Med. 2008; 14: 147-56. [DOI:10.1089/acm.2007.0693]
13. Mozaffarpur SA, Naseri M, Kamalinejad M, Shams MA, Memariani Z, Moeini R, Gorji N, Moradi Farahani A and Shirafkan H. Nine steps to discover new medicines from traditional sources: the example of Persian medicine. J. Altern. Complement. Med. 2020; 26: 365-8. [DOI:10.1089/acm.2019.0377]
14. Ghaffari F, Alijaniha F and Fallahi F. Single remedies for Khafaghan in Iranian traditional medicine. J. Islam. Iran. Tradit. Med. 2013; 4: 1-1.
15. Khodaie SA, Kamalinejad M, Emadi F and Naseri M. Prioritization of effective Materia Medica on diabetic foot ulcer in Persian medicine. Daneshvar Med: Basic Clin. Res. J. 2020; 25: 45-54.
16. Gibbs RS, Karlan BY, Haney AF and Nygaard IE. Editors. Danforth's obstetrics and gynecology. 10th ed., Lippincott Williams & Wilkins; 2008.
17. Bozdag G, Mumusoglu S, Zengin D, Karabulut E and Yildiz BO. The prevalence and phenotypic features of polycystic ovary syndrome: a systematic review and meta-analysis. Hum. Reprod. 2016; 31: 2841-55. [DOI:10.1093/humrep/dew218]
18. Liu Y, Li J, Yan Z, Liu D, Ma J and Tong N. Improvement of insulin sensitivity increases pregnancy rate in infertile PCOS women: a systemic review. Front. Endocrinol. 2021; 12: 317. [DOI:10.3389/fendo.2021.657889]
19. Rosenfield RL. Identifying children at risk for polycystic ovary syndrome. J. Clin. Endocrinol. Metab. 2007; 92: 787-96. [DOI:10.1210/jc.2006-2012]
20. Franks S, Stark J and Hardy K. Follicle dynamics and anovulation in polycystic ovary syndrome. Hum. Reprod. Update. 2008; 14: 367-78. [DOI:10.1093/humupd/dmn015]
21. Lim SS, Norman RJ, Davies MJ and Moran LJ. The effect of obesity on polycystic ovary syndrome: a systematic review and meta-analysis. Obes. Rev. 2013; 14: 95-109. [DOI:10.1111/j.1467-789X.2012.01053.x]
22. Jahromi BN, Dabaghmanesh MH, Parsanezhad ME and Fatehpoor F. Association of leptin and insulin resistance in PCOS: A case-controlled study. Int. J. Reprod. Biomed. 2017; 15: 423. [DOI:10.29252/ijrm.15.7.423]
23. Trikudanathan S. Polycystic ovarian syndrome. Med. Clin. 2015; 99: 221-35. [DOI:10.1016/j.mcna.2014.09.003]
24. Legro RS, Arslanian SA, Ehrmann DA, Hoeger KM, Murad MH, Pasquali R and Welt CK. Diagnosis and treatment of polycystic ovary syndrome: An Endocrine Society clinical practice guideline. J. Clin. Endocrinol. Metab. 2013; 98: 4565-92. [DOI:10.1210/jc.2013-2350]
25. Diamanti-Kandarakis E, Baillargeon JP, Iuorno MJ, Jakubowicz DJ and Nestler JE. A modern medical quandary: polycystic ovary syndrome, insulin resistance, and oral contraceptive pills. J. Clin. Endocrinol. Metab. 2003; 88: 1927-32. [DOI:10.1210/jc.2002-021528]
26. Rhazes, Al-havi fi al-tebb. Lebanon: Daar Ehya Al-toraath Publication; 2001. [In Arabic]
27. Avicenna. Al-Qanon fi al-Tibb (The Canon of Medicine). Lebanon: Alamy Le al-Matbooat Institute; 2005. [In Arabic]
28. Jorjani E. Aghraz al-tebbiah va al-mabahes al-alaaeiah. Tehran: Farhang Iran Publication; 1966. [In Persian]
29. Tonekaboni MM. Tohfa al-momenin. Qom: Noor-e-vahy Publication; 2011. [In Persian]
30. Aghili Shirazi MH. Makhzan al adviyeh (store house of medicaments). Tehran: TUMS; 2009. [In Persian]
31. Iranshahy M and Iranshahi M. Traditional uses, phytochemistry and pharmacology of asafoetida (Ferula assa-foetida oleo-gum-resin)-A review. J. Ethnopharmacol. 2011; 134: 1-0. [DOI:10.1016/j.jep.2010.11.067]
32. Niazmand R and Razavizadeh BM. Ferula asafoetida: chemical composition, thermal behavior, antioxidant and antimicrobial activities of leaf and gum hydroalcoholic extracts. J. Food Sci. Technol. 2021; 58: 2148-59. [DOI:10.1007/s13197-020-04724-8]
33. Ou S and Kwok KC. Ferulic acid: pharmaceutical functions, preparation and applications in foods. J. Sci. Food Agric. 2004; 84: 1261-9. [DOI:10.1002/jsfa.1873]
34. Azizian H, Rezvani ME, Esmaeilidehaj M and Bagheri SM. Antiobesity, fat lowering and liver steatosis protective effects of Ferula asafoetida gum in type 2 diabetic rats: possible involvement of leptin. Iran. J. Diabetes. Obes. 2012; 4: 120-6.
35. Iranshahi M and Alizadeh M. Antihyperglycemic effect of asafoetida (Ferula assafoetida oleo-gum-resin) in streptozotocin-induced diabetic rats. World Appl. Sci. J. 2012; 17: 157-62.
36. Amalraj A and Gopi S. Biological activities and medicinal properties of Asafoetida: A review. J. Tradit. Complement. Med. 2017; 7: 347-59. [DOI:10.1016/j.jtcme.2016.11.004]
37. Gruenwald J, Brendler T and Jacnicke C. PDR for Herbal Medicine. Medical Economics Company; 2000.
38. Ibn-e-Nafis A. Al-shamel fi al-sanaah al-tebbiah. Tehran: Tehran University of Medical Sciences; 2008. [In Arabic]
39. Mahendra P and Bisht S. Ferula asafoetida: Traditional uses and pharmacological activity. Pharmacogn Rev. 2012; 6: 141. [DOI:10.4103/0973-7847.99948]
40. Ghavi F, Shakeri F and Taebi M. Effects of Ferula assa-foetida on clinical, hormonal and ultrasound parameters in young girls with polycystic ovary syndrome: a randomized, placebo controlled, triple-blinded [Internet]. Res. Sq. [Preprint]. 2022 [cited 2022 Feb 7]: 13 p. Available from:
41. Moini Jazani A, Hamdi K, Tansaz M, Nazemiyeh H, Sadeghi Bazargani H, Fazljou SM and Nasimi Doost Azgomi R. Herbal medicine for oligomenorrhea and amenorrhea: a systematic review of ancient and conventional medicine. Biomed. Res. Int. 2018. [DOI:10.1155/2018/3052768]
42. Esmaeili A and Amiri H. The in vitro antioxidant and antibacterial activities of Tanacetum pinnatum boiss. grown in Iran. Bulgarian Chem. Com. 2011; 43: 267-71.
43. Soleymani M, Ramezani M and Siadat F. The effects of Tanacetum parthenium hydroalchoholic extract on the sex hormones of NMRI mouse. J. Anim. Biol. 2016; 8: 39-45. Available from: https: //www.sid.ir/en/journal/ ViewPaper.aspx?id=511904. [In Persian]
44. Pareek A, Suthar M, Rathore GS and Bansal V. Feverfew (Tanacetum parthenium L.): A systematic review. Pharmacogn Rev. 2011; 5: 103. [DOI:10.4103/0973-7847.79105]
45. Golestaneh Talaei M and Jahandideh M. Anti-inflammatory activity of Cymbopogon schoenanthus essential oil in animal models. Res. J. Pharmacogn. 2019; 6: 61-8.
46. Rudnicka E, Suchta K, Grymowicz M, Calik-Ksepka A, Smolarczyk K, Duszewska AM, Smolarczyk R and Meczekalski B. Chronic low grade inflammation in pathogenesis of PCOS. Int. J. Mol. Sci. 2021; 22: 3789. [DOI:10.3390/ijms22073789]
47. Artimani T, Karimi J, Mehdizadeh M, Yavangi M, Khanlarzadeh E, Ghorbani M, Asadi S and Kheiripour N. Evaluation of pro-oxidant-antioxidant balance (PAB) and its association with inflammatory cytokines in polycystic ovary syndrome (PCOS). Gynecol Endocrinol. 2018; 34: 148-52. [DOI:10.1080/09513590.2017.1371691]
48. Khadri A, Neffati M, Smiti S, Falé P, Lino AR, Serralheiro ML and Araújo ME. Antioxidant, antiacetylcholinesterase and antimicrobial activities of Cymbopogon schoenanthus L. Spreng (lemon grass) from Tunisia. LWT- Food Sci. Technol. 2010; 43: 331-6. [DOI:10.1016/j.lwt.2009.08.004]
49. Jalilian N, Modarresi M, Rezaie M, Ghaderi L and Bozorgmanesh M. Phytotherapeutic management of polycystic ovary syndrome: role of aerial parts of wood betony (Stachys lavandulifolia). Phytother. Res. 2013; 27: 1708-13. [DOI:10.1002/ptr.4921]
50. Hajimonfarednejad M, Nimrouzi M, Heydari M, Zarshenas MM, Raee MJ and Jahromi BN. Insulin resistance improvement by cinnamon powder in polycystic ovary syndrome: A randomized double‐blind placebo controlled clinical trial. Phytother. Res. 2018; 32: 276-83. [DOI:10.1002/ptr.5970]
51. Grant P. Spearmint herbal tea has significant anti‐androgen effects in polycystic ovarian syndrome. a randomized controlled trial. Phytother. Res. 2010; 24:186-8. [DOI:10.1002/ptr.2900]
52. Hosseinkhani A, Asadi N, Pasalar M and Zarshenas MM. Traditional Persian medicine and management of metabolic dysfunction in polycystic ovary syndrome. J. Tradit. Complement Med. 2018; 8: 17-23. [DOI:10.1016/j.jtcme.2017.04.006]
53. Sahranavard S, Ghafari S and Mosaddegh M. Medicinal plants used in Iranian traditional medicine to treat epilepsy. Seizure. 2014; 23: 328-32. [DOI:10.1016/j.seizure.2014.01.013]

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