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Naseri L, Akbari bazm M, Khazaei M. A Review on Therapeutic Effects of Tribulus terrestris. J. Med. Plants. 2019; 18 (72) :1-22
1- Ph.D. Candidate of Anatomical Sciences, Fertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
2- Ph.D. of Anatomical Sciences, Fertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran ,
Abstract:   (15157 Views)
Tribulus terrestris is a one-year-old herb dispersed in hot and humid areas in the Mediterranean and warm regions of Europe, Asia, Africa and Australia. This plant has many benefits and is used in traditional medicine for the treatment of various diseases, including kidney stones, low blood pressure, anti-diabetic properties, and treatment of cardiovascular diseases, gastrointestinal disorders, and sexual performance in men and in treatment of hepatitis is recommended. The aim of this study was to investigate the pharmacological and therapeutic properties of pharynx in traditional medicine and scientific papers in modern medicine. This study is a systematic review based on the PRISMA checklist. Based on keywords, 440 titles were selected and after removing repetitive articles, 129 papers were extracted from various databases including PubMed, SID, ScienceDirect, Scopus and Magiran, and the Google Scholar search engine without time limit. T. terrestris has several properties, including antimicrobial, antibacterial, free radicals purification and inhibition of lipid peroxidation, and through various mechanisms of cell and molecules, it produces various pharmacological and therapeutic properties. One of the most important therapeutic properties of this plant is its anti-inflammatory and anti-cancer properties. Also, several clinical studies have shown that co-administration of tetanus extract with chemotherapy drugs reduces the side effects of drugs. Due to the lack of toxicity and side effects of T. terrestris, the use of herbs has been considered as a complementary drug in diet regimens for various diseases.
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Type of Study: Review | Subject: Pharmacognosy & Pharmaceutics
Received: 2018/06/29 | Accepted: 2018/09/25 | Published: 2019/10/28

1. Van Wyk B.E. and Wink M. Medicinal plants of the world (No. Ed. 2). 2017, 520 CABI. [DOI:10.1079/9781786393258.0000]
2. Adaikan PG, Gauthaman K and Prasad RN. History of herbal medicines with an insight on the pharmacological properties of T. terrestris. The Aging Male. 2001; 4: 163-9. [DOI:10.1080/tam.]
3. Rogerson S, Riches CJ, Jennings C and Weatherby RP. The effect of five weeks of T.terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players. J. Strength Cond Res. 2007; 21: 348. [DOI:10.1519/R-18395.1]
4. Wang B, Ma L and Liu T. 406 cases of angina pectoris in coronary heart disease treated with saponin of T. terrestris. Chinese J. Modern Developments in Traditional Medicine 1990; 10: 85-7.
5. Kirby AJ and Schmidt RJ. The antioxidant activity of Chinese herbs for eczema and of placebo herbs. I. J. Ethnopharmacol. 1997; 56: 8-103. [DOI:10.1016/S0378-8741(97)01510-9]
6. Abirami P and Rajendran A. GC-MS Analysis of T.terrestris. Asian J. Plant Sci. Res. 2011; 1: 13-6.
7. Samy MN, Bishr MM, Ahmed AA, Sayed HM and Kamel MS. Pharmacognostical studies on flower of T. terrestris L. J. Pharmacogn. Phytochem. 2013; 1: 19-23.
8. Duke J, Duke PK and Cellier JL. Duke Handbook of medicinal herbs. 2nd edn. CRC Press. United States. 2002, p: 595. [DOI:10.1201/9781420040463]
9. Kokate CK, Purohit AP and Gokhale SB. Pharmacognosy. 13th ed. Nirali Prakashan Publisher. Pune. 2007: 370.
10. Aqili Khorasani and Makhzan ol-Advieh. Enghelab e Eslami publishing and Educational Organization. Correction by Dr. Kahni et al. Tehran 1992: 331.
11. Kamali Nezhad M. Mofaradat pezeshki barg kohan, Tehran, Chogan, First edition, 2011: 38.
12. Yousef bin Mohammad Herawi and Riaz ala Dawiya. Introduction and Correction Dr. Seyed Mohammad Nazari, Tehran, Al-Muhi, 2012, First edi,: 74.
13. Georgiev GI, Ivanova A, Mechkarova P, Ivanova A and Popova L. Rate and forms of mineral nutrition CAN influence dry matter accumulation and saponin content of Puncture Vine (T. terrestris L.). Biotechnol Biotechnol Equip. 2010 Jan 1; 24 (sup. 1): 49-52. [DOI:10.1080/13102818.2010.10817810]
14. Hassan LG, Umar KJ and Umar Z. Antinutritive factors in T.terrestris (Linn) leaves and predicted calcium and zinc bioavailability. J. Trop. Biosci. 2007; 7: 33-6.
15. Bhandari B, Chopra D and Kohli SK. Pharmacological effects of T. terrestris: A Review. IJCAM. 2013; 1: 71. [DOI:10.5958/j.2321-1032.1.1.009]
16. Kostova I and Dinchev D. Saponins in T. terrestris-chemistry and bioactivity. Phytochemistry Reviews 2005; 4: 111-37. [DOI:10.1007/s11101-005-2833-x]
17. Lu TX, Shu T, Qin XJ, Ni W, Ji YH, Chen QR, Khan A, Zhao Q and Liu HY. Spirostanol saponins from Ypsilandra parviflora induce platelet aggregation. Steroids J. 2017; 123: 55-60. [DOI:10.1016/j.steroids.2017.05.004]
18. Huang YL, Kou JP, Ma L, Song JX and Yu BY. Possible mechanism of the anti-inflammatory activity of ruscogenin: role of intercellular adhesion molecule-1 and nuclear factor-κB. J. Pharmacol. Sci. 2008; 108: 198-205. [DOI:10.1254/jphs.08083FP]
19. Xu YJ, Xu TH, Zhou HO, Li B, Xie SX, Si YS, Liu Y, Liu TH and Xu DM. Two new furostanol saponins from T. terrestris. J. Asian Nat. Prod. Res. 2010; 12: 349-54. [DOI:10.1080/10286021003747458]
20. Voutquenne L. Saponins and hemolytic activity. Saponins and glycosides from five species of Sapindaceae. Ann. Pharm. Fr. 2001; 59: 407-414.
21. Margarat A and Jagadeesan G. Effect of T.terrestris extract on mercuric chloride poisoning in mice, Mus musculus-a biochemical study. Indian J. Environment and Toxicol. 2000; 10: 14-5.
22. Shi J, Arunasalam K, Yeung D, Kakuda Y, Mittal G and Jiang Y. Saponins from edible legumes: chemistry, processing, and health benefits. J. Med. Food 2004; 7: 67-78. [DOI:10.1089/109662004322984734]
23. Zhang SJ, Qu WJ and Zhong SY. Inhibitory effects of saponins from T.terrestris on alpha-glucosidase in small intestines of rats. Zhongguo China J. Chinese Materia Medica 2006; 31: 910-3.
24. Xu YJ, Xie SX, Zhao HF, Han D, Xu TH and Xu DM. Studies on the chemical constituents from T.terrestris. Acta Pharmacol Sin. 2001; 36: 750-3.
25. Wang S, Ji Y, Li H and Yang S. Mechanisms of gross saponins of T. terrestris via activating PKC epsilon against myocardial apoptosis induced by oxidative stress. Acta Pharmacol. Sin. 2009; 44: 134-9.
26. Bhutani SP, Chibber SS and Seshadri TR. Flavonoids of the fruits and leaves of T.terrestris: constitution of tribuloside. Phytochem. 1969; 8: 299-303. [DOI:10.1016/S0031-9422(00)85828-8]
27. Louveaux A, Jay M, El Hadi OT and Roux G. Variability in flavonoid compounds of four Tribulus species: does it play a role in their identification by desert locust Schistocerca gregaria? J. Chem. Ecol. 1998; 24: 1465-81. [DOI:10.1023/A:1020903631798]
28. Tomowa M and Gyulemetow R. Steroid and steroid sapogenine from Tribulus terrestrits. Planta Medica 1979; 34: 188-191. [DOI:10.1055/s-0028-1097434]
29. Zakowa S and Peewa S. Steroidal saponine from T.terrestris with a stimulating action on the sexual function. Int. Conf. Chem. Biotechnol. Biol. Act. Nat. 1981; 3: 298 - 302.
30. Matin Yekta M, Alavi SHR, Hajiaghaee R and Ajani Y. Flavonoid Glycosides from Tribulus terriestris L. orientalis. Iran. J. Pharm. Sci. 2008; 4: 231-6.
31. El-Tantawy WH, Temraz A and El-Gindi OD. Free serum testosterone level in male rats treated with Tribulus alatus extracts. Brazilian J. Urology 2007; 33: 554-9. [DOI:10.1590/S1677-55382007000400015]
32. Amin AM, Lotfy M, Shafiullah M and Adeghate E. The protective effect of T. terrestris in diabetes. Ann. N Y Acad Sci. 2006; 1084: 391-401. [DOI:10.1196/annals.1372.005]
33. Harborne JB and Williams CA. Advances in flavonoid research since 1992. Phytochem. 2000; 55: 481-504. [DOI:10.1016/S0031-9422(00)00235-1]
34. Wu TS, Shi LS and Kuo SC. Alkaloids and other constituents from T. terrestris. Phytochem. 1999; 50: 1411-5. [DOI:10.1016/S0031-9422(97)01086-8]
35. Lin FH, Lin JY, Gupta RD, Tournas JA, Burch JA, Selim MA, Monteiro-Riviere NA, Grichnik JM, Zielinski J and Pinnell SR. Ferulic acid stabilizes a solution of vitamins C and E and doubles its photoprotection of skin. J. Investig. Dermatol. 2005; 125: 826-32. [DOI:10.1111/j.0022-202X.2005.23768.x]
36. Kim TH, Lim HJ, Kim MS and Lee MS. Dietary supplements for benign prostatic hyperplasia: An overview of systematic reviews. Maturitas 2012; 73: 180-5. [DOI:10.1016/j.maturitas.2012.07.007]
37. Assmann G, Cullen P, Erbey J, Ramey DR, Kannenberg F and Schulte H. Plasma sitosterol elevations are associated with an increased incidence of coronary events in men: results of a nested case-control analysis of the Prospective Cardiovascular Münster (PROCAM) study. Nutr. Metab. Cardiovasc. Dis. 2006; 16: 13-21. [DOI:10.1016/j.numecd.2005.04.001]
38. Adaikan PG, Gauthaman K, Prasad RN and Ng SC. Proerectile pharmacological effects of T.terrestris extract on the rabbit corpus cavernosum. Ann. Acad. Med. Singapore 2000; 29: 22-6.
39. Chung BH, Mitchell SH, Zhang JS and Young CY. Effects of docosahexaenoic acid and eicosapentaenoic acid on androgen-mediated cell growth and gene expression in LNCaP prostate cancer cells. Carcinogenesis 2001; 22: 1201-6. [DOI:10.1093/carcin/22.8.1201]
40. Bremner J, Sengpracha W, Southwell I, Bourke C, Skelton B and White A. The Alkaloids of T. terrestris: A revised structure for the Alkaloid Tribulusterine. InIII WOCMAP Congress on Medicinal and Aromatic Plants. Perspectives in Natural Product Chemistry 2003; 3: 11-17. [DOI:10.17660/ActaHortic.2005.677.1]
41. Wu TS, Shi LS and Kuo SC. Alkaloids and other constituents from T. terrestris. Phytochemistry 1999; 50: 1411-5. [DOI:10.1016/S0031-9422(97)01086-8]
42. Raja M and Venkataraman R. Pharmaco- gnostical studies on T. terrestris and Tribulus alatus. Der Pharmacia Sinica. 2011; 2: 136-139.
43. Abdali-Mashhadi AR, Direkvand-Moghadam F, Albobaji M, Direkvand-Moghadam A and Delpisheh A. The measurement of the quercetin of different parts of T. terrestris by HPLC. Adv. Herb. Med. 2015; 1: 21-6.
44. Shi J, Arunasalam K, Yeung D, Kakuda Y, Mittal G and Jiang Y. Saponins from edible legumes: chemistry, processing, and health benefits. J. Med. Food 2004; 7: 67-78. [DOI:10.1089/109662004322984734]
45. Jan AT, Kamli MR, Murtaza I, Singh JB, Ali A and Haq QM. Dietary flavonoid quercetin and associated health benefits- an overview. Food Rev. Int. 2010; 26: 302-17. [DOI:10.1080/87559129.2010.484285]
46. Cao R, Peng W, Wang Z and Xu A. β-Carboline alkaloids: biochemical and pharmacological functions. Curr. Med. Chem. 2007; 14: 479-500. [DOI:10.2174/092986707779940998]
47. Guofeng Gu, Li GL, Xu HJ, Xu SH, Wang WW, Yu BY and Zhang J. Synthesis of tigogenin MeON-Neoglycosides and their antitumor activity. Fitoterapia. 2018; 125: 33-40. [DOI:10.1016/j.fitote.2017.12.014]
48. Ma W, Ding H, Gong X, Liu Z, Lin Y, Zhang Z and Lin G. Methyl protodioscin increases ABCA1 expression and cholesterol efflux while inhibiting gene expressions for synthesis of cholesterol and triglycerides by suppressing SREBP transcription and microRNA 33a/b levels. Atherosclerosis 2015; 239 (2): 566-70. [DOI:10.1016/j.atherosclerosis.2015.02.034]
49. Zhang X, Xue X, Xian L, Guo Z, Ito Y and Sun W. Potential neuroprotection of protodioscin against cerebral ischemia-reperfusion injury in rats through intervening inflammation and apoptosis. Steroids 2016; 113: 52-63. [DOI:10.1016/j.steroids.2016.06.008]
50. Adimoelja A and Adaikan PG. Protodioscin from herbal plant Tribulus terrestris L improve the male sexual functions, probably via DHEA. Int. J. Impot. Res. 1997; 9 (supp 1): S1-70.
51. Gama KB, Quintans JS, Antoniolli AR, Quintans-Júnior LJ, Santana WA, Branco A, Soares MB and Villarreal CF. Evidence for the involvement of descending pain-inhibitory mechanisms in the antinociceptive effect of hecogenin acetate. J. Natural Products 2013; 25: 559-63. [DOI:10.1021/np3007342]
52. Wang Y, Li C, Xiang L, Huang W and He X. Spirostanol saponins from Chinese onion (Allium chinense) exert pronounced anti-inflammatory and anti-proliferative activities. J. Functional Foods 2016. 1; 25: 208-19. [DOI:10.1016/j.jff.2016.06.005]
53. Villarreal ML, Arias C, Feria-Velasco A, Ramírez OT and Quintero R. Cell suspension culture of Solanum chrysotrichum (Schldl.)-A plant producing an antifungal spirostanol saponin. Plant Cell, Tissue and Organ Culture 1997; 50 (1): 39-44. [DOI:10.1023/A:1005850422063]
54. Fu Yl, Yu Zy, Tang Xm, Zhao Y, Yuan Xl, Wang S, MA BP and CONG YW. Pennogenin glycosides with a spirostanol structure are strong platelet agonists: structural requirement for activity and mode of platelet agonist synergism. J. Thrombosis and Haemostasis 2008; 6 (3): 524-33. [DOI:10.1111/j.1538-7836.2007.02881.x]
55. Hämäläinen M, Nieminen R, Vuorela P, Heinonen M and Moilanen E. Anti-inflammatory effects of flavonoids: genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-κB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-κB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages. Mediators Inflamm. 2007; 2007: 45673. [DOI:10.1155/2007/45673]
56. García-Mediavilla V, Crespo I, Collado PS, Esteller A, Sánchez-Campos S, Tuñón MJ and González-Gallego J. The anti-inflammatory flavones quercetin and kaempferol cause inhibition of inducible nitric oxide synthase, cyclooxygenase-2 and reactive C-protein, and down-regulation of the nuclear factor kappaB pathway in Chang Liver cells. European J. Pharmacol. 2007 Feb 28; 557 (2-3): 221-9. [DOI:10.1016/j.ejphar.2006.11.014]
57. Kafeel H and Rukh R. Anxiolytic activity of ethanolic extract of aerial parts of Tribulus terrestris in mice. J. Phytopharmacol. 2015; 4 (1): 17-21.
58. Totsuka Y, Ushiyama H, Ishihara J, Sinha R, Goto S, Sugimura T and Wakabayashi K. Quantification of the co-mutagenic β-carbolines, norharman and harman, in cigarette smoke condensates and cooked foods. Cancer Letters 1999; 143 (2): 139-43. [DOI:10.1016/S0304-3835(99)00143-3]
59. Herraiz T and Chaparro C. Human monoamine oxidase enzyme inhibition by coffee and β-carbolines norharman and harman isolated from coffee. Life Sciences 2006; 78: 795-802. [DOI:10.1016/j.lfs.2005.05.074]
60. Farzin D and Mansouri N. Antidepressant-like effect of harmane and other β-carbolines in the mouse forced swim test. European Neuropsychopharmacol. 2006; 16 (5): 324-8. [DOI:10.1016/j.euroneuro.2005.08.005]
61. Zarian A, Malekaneh M, Hasanpour M, Najari MT and Abad M. Antioxidant properties of 28 medicinal plants in Iran. J. Birjand University of Medical Sciences 2005; 11: 9-15.
62. Hammoda HM, Ghazy NM, Harraz FM, Radwan MM, ElSohly MA and Abdallah II. Chemical constituents from T. terrestris and screening of their antioxidant activity. Phytochem. 2013; 92: 153-9. [DOI:10.1016/j.phytochem.2013.04.005]
63. Zheleva-Dimitrova DI, Obreshkova DA and Nedialkov P. Antioxidant activity of T. terrestris-a natural product in infertility therapy. Int. J. Pharm. Pharm. Sci. 2012; 4: 508-11.
64. Oh JS, Baik SH, Ahn EK, Jeong W and Hong SS. Anti-inflammatory activity of T. terrestris in RAW264. 7 Cells. J. Immunol. 2012; 188: 54-2.
65. Baburao B, Rajyalakshmi G, Venkatesham A, Kiran G, Shyamsunder A and Gangarao B. Anti‑inflammatory and antimicrobial activities of methanolic extract of T. terrestris linn plant. Int. J. Chem. Sci. 2009; 7: 1867 - 72.
66. Heidari MR, Mehrabani M, Pardakhty A, Khazaeli P, Zahedi MJ, Yakhchali M and Vahedian M. The analgesic effect of T.terrestris extract and comparison of gastric ulcerogenicity of the extract with indomethacine in animal experiments. Ann. N. Y. Acad. Sci. 2007; 1095: 418-27. [DOI:10.1196/annals.1397.045]
67. Verma PR, Joharapurkar AA, Chatpalliwar VA and Asnani AJ. Antinociceptive activity of alcoholic extract of Hemidesmus indicus R. Br. in mice. J. Ethnopharmacol. 2005; 102: 298-301. [DOI:10.1016/j.jep.2005.05.039]
68. Lee HH, Ahn EK, Hong SS and Oh JS. Anti-inflammatory effect of tribulusamide D isolated from T. terrestris in lipopolysaccharide-stimulated RAW264. 7 macrophages. Mol. Med. Rep. 2017; 16: 4421-8. [DOI:10.3892/mmr.2017.7208]
69. Ko HJ, Ahn EK and Oh JS. N‑trans‑ρ‑caffeoyl tyramine isolated from T.terrestris exerts anti‑inflammatory effects in lipopolysaccharide‑stimulated RAW 264.7 cells. Int. J. Mol. Med. 2015; 36: 1042-8. [DOI:10.3892/ijmm.2015.2301]
70. Borran M., Minaiyan M., Zolfaghari B. and Mahzouni P. Protective effect of T.terrestris fruit extract on cerulein-induced acute pancreatitis in mice. Avicenna J. Phytomedicine 2017; 7 (3): 250-260.
71. Kang SY, Jung HW, Nam JH, Kim WK, Kang JS, Kim YH, Cho CW, Cho CW, Park YK and Bae HS. Effects of the fruit extract of T.terrestris on skin inflammation in mice with Oxazolone-induced atopic dermatitis through regulation of calcium channels, Orai-1 and TRPV3, and mast cell activation. . Evid Based Complement Alternat Med. 2017; 2017: 8312946. [DOI:10.1155/2017/8312946]
72. Man S, Gao W, Zhang Y, Huang L and Liu C. Chemical study and medical application of saponins as anti-cancer agents. Fitoterapia 2010; 81: 703-14. [DOI:10.1016/j.fitote.2010.06.004]
73. Kim HJ, Kim JC, Min JS, Kim MJ, Kim JA, Kor MH, Yoo HS and Ahn JK. Aqueous extract of T. terrestris Linn induces cell growth arrest and apoptosis by down-regulating NF-κB signaling in liver cancer cells. J. Ethnopharmacol. 2011; 136:197-203. [DOI:10.1016/j.jep.2011.04.060]
74. Wei S, Fukuhara H, Chen G, Kawada C, Kurabayashi A, Furihata M, Inoue K and Shuin T. Terrestrosin D, a steroidal saponin from T. terrestris L., inhibits growth and angiogenesis of human prostate cancer in vitro and in vivo. Pathobiol. 2014; 81: 123-32. [DOI:10.1159/000357622]
75. Kumar M, Soni AK, Shukla S and Kumar A. chemopreventive potential of T. terrestris against 7, 12-dimethylbenz (a) anthracene induced skin papillomagenesis in mice. Asian Pac. J. Cancer Prev. 2006; 7: 289-94.
76. Kim HJ, Kim JC, Min JS, Kim MJ, Kim JA, Kor MH, Yoo HS and Ahn JK. Aqueous extract of T.terrestris Linn induces cell growth arrest and apoptosis by down-regulating NF-κB signaling in liver cancer cells. J. Ethnopharmacol. 2011; 136: 197-203. [DOI:10.1016/j.jep.2011.04.060]
77. Neychev VK, Nikolova E, Zhelev N and Mitev VI. Saponins from T. terrestris L. are less toxic for normal human fibroblasts than for many cancer lines: Influence on apoptosis and proliferation. Experimental Biology and Medicine 2007 Jan; 232 (1): 126-33.
78. Deole YS, Chavan SS, Ashok BK, Ravishankar B, Thakar AB and Chandola HM. Evaluation of anti-depressant and anxiolytic activity of Rasayana Ghana Tablet (A compound Ayurvedic formulation) in albino mice. Ayu. 2011; 32: 375. [DOI:10.4103/0974-8520.93918]
79. Liu XM, Huang QF, Zhang YL, Lou JL and Zheng H. Effects of T. terrestris L. saponin on apoptosis and changes in cytosolic calcium induced by hypoxia/reoxygenation in rat cortical neurons [J]. Chinese Journal of Pathophysiology (CJPP). 2007; 5: 25.
80. Liu XM, Huang QF, Zhang YL, Lou JL, Liu HS and Zheng H. Effects of T. terrestris L. saponion on apoptosis of cortical neurons induced by hypoxia-reoxygenation in rats. Zhong xi yi jie Journal of Chinese integrative medicine. 2008; 6 (1): 45-50. [DOI:10.3736/jcim20080110]
81. Wang Z, Zhang D, Hui S, Zhang Y and Hu S. Effect of T. terrestris saponins on behavior and neuroendocrine in chronic mild stress depression rats. Journal of Traditional Chinese Medicine 2013 1; 33 (2): 228-32. [DOI:10.1016/S0254-6272(13)60130-2]
82. Zhang S, Li H and Yang SJ. Tribulosin protects rat hearts from ischemia/reperfusion injury. Acta Pharmacol. Sin. 2010; 31: 671. [DOI:10.1038/aps.2010.45]
83. Phillips OA, Mathew KT and Oriowo MA. Antihypertensive and vasodilator effects of methanolic and aqueous extracts of T. terrestris in rats. J. Ethnopharmacol. 2006; 104: 351-355. [DOI:10.1016/j.jep.2005.09.027]
84. Zhang S, Li H, Xu H and Yang SJ. Effect of gross saponins of T.terrestris on cardiocytes impaired by Adriamycin. Acta Pharmacol. Sin. 2010; 45: 31-36. [DOI:10.1038/aps.2010.45]
85. Phillips OA, Mathew KT and Oriowo MA. Antihypertensive and vasodilator effects of methanolic and aqueous extracts of T.terrestris in rats. J. Ethnopharmacol. 2006; 104: 351-5. [DOI:10.1016/j.jep.2005.09.027]
86. Olas B, Morel A, Hamed AI, Oleszek W and Stochmal A. Evaluation of polyphenolic fraction isolated from aerial parts of Tribulus pterocarpus on biological properties of blood platelets in vitro. Platelets 2013; 24: 156-61. [DOI:10.3109/09537104.2012.671979]
87. Lamba HS, Bhargava CS, Thakur MA and Bhargava SH. α-glucosidase and Aldose reductase inhibitory activity in vitro and anti-diabetic activity in vivo of T. terrestris L. (Dunal). Int. J. Pharm. Pharm. Sci. 2011; 3: 270-2.
88. Ponnusamy S, Ravindran R, Zinjarde S, Bhargava S and Ravi Kumar A. Evaluation of traditional Indian antidiabetic medicinal plants for human pancreatic amylase inhibitory effect in vitro. Evid Based Complement Alternat Med. 2011; 2011: 515647. [DOI:10.1155/2011/515647]
89. Roghani M, Baluchnejad Mojarrad T, Andalibi N, Ansari F and Sharayeli M. Effect of consumption of T. terrestris on serum glucose and lipid levels in diabetic rats. Journal of Shaheed Sadoughi Univ of Meی Sci. 2010; 18: 17-23. [DOI:10.33899/ijvs.2009.5682]
90. Lamba HS, Bhargava CH, Thakur M and Bhargava S. α‑ glucosidase and aldose reductase inhibitory activity in vitroand antidiabetic activity in vivoof T. terrestris. Int. J. Pharm. Pharma. Sci. 2011; 3: 270-2.
91. Amin AM, Lotfy M, Shafiullah M and Adeghate E. The protective effect of T. terrestris in diabetes. Ann. N Y Acad. Sci. 2006; 1084: 391-401. [DOI:10.1196/annals.1372.005]
92. Bonakdaran A, Fallah Huseini H, Khalighi-Sigaroodi F, Abdoli M and Ahvazi M. Investigation of the hypoglycemic effect of T.terrestris extract on diabetic rats. J. Med. Plant Res. 2008; 2: 85-92.
93. Kavitha P, Ramesh R, Bupesh G, Stalin A and Subramanian P. Hepatoprotective activity of T. terrestris extract against acetaminophen-induced toxicity in a freshwater fish (Oreochromis mossambicus). ‎In Vitro Cell Dev Biol-Animal. 2011; 47: 698-706. [DOI:10.1007/s11626-011-9457-9]
94. Hejazi L and Hosseini E. The effect of T. terrestris extract on hepatic complications due to the gelofen consumption in adult female rats. J. Fasa Univ. Med. Sci. 2016; 6: 61-155.
95. Almasi F, Khazaei M, Chehrei S and Ghanbari A. Hepatoprotective effects of tribulus terrestris hydro-alcholic extracton non-alcoholic fatty liver- induced rats. Int. J. Morphol. 2017; 35 (1): 345-50 [DOI:10.4067/S0717-95022017000100054]
96. Khan S, Kabir H, Jalees F, Asif M and Naquvi KJ. Antihyperlipidemic potential of fruits of T. terrestris linn. Int. J. Biomed. Res. 2011; 2: 98-101. [DOI:10.7439/ijbr.v2i1.79]
97. Tuncer MA, Yaymaci B, Sati L, Cayli S, Acar G, Altug T and Demir R. Influence of T. terrestris extract on lipid profile and endothelial structure in developing atherosclerotic lesions in the aorta of rabbits on a high-cholesterol diet. Acta Histochemica. 2009; 111: 488-500. [DOI:10.1016/j.acthis.2008.06.004]
98. Marrelli M, Conforti F, Araniti F and Statti GA. Effects of saponins on lipid metabolism: a review of potential health benefits in the treatment of obesity. Molecules 2016; 21: 1404. [DOI:10.3390/molecules21101404]
99. Sangeeta D, Sidhu H, Thind SK and Nath R. Effect of T.terrestris on oxalate metabolism in rats. J. Ethnopharmacol. 1994; 44: 61-6. [DOI:10.1016/0378-8741(94)90069-8]
100. Anand R, Patnaik GK, Kulshreshtha DK, Dhawan BN. Activity of certain fractions of T. terrestris fruits against experimentally induced urolithiasis in rats. Indian. J. Exp. Biol. 1994; 32: 548-52. [DOI:10.3109/13880209409082997]
101. Raoofi A, Khazaei M and Ghanbari A. Protective effect of hydroalcoholic extract of T. terrestris on Cisplatin induced renal tissue damage in male mice. Int. J. Prev. Med. 2015; 6: 11. [DOI:10.4103/2008-7802.151817]
102. Sharifi AM, Darabi R and Akbarloo N. Study of antihypertensive mechanism of T. terrestris in 2K1C hypertensive rats: role of tissue ACE activity. Life Sci. 2003; 73: 2963-71. [DOI:10.1016/j.lfs.2003.04.002]
103. Phillips OA, Mathew KT, Oriowo MA. Antihypertensive and vasodilator effects of methanolic and aqueous extracts of T. terrestris in rats. J. Ethnopharmacol. 2006; 104: 351-5. [DOI:10.1016/j.jep.2005.09.027]
104. Al-Ali M, Wahbi S, Twaij H, Al-Badr A. T. terrestris: preliminary study of its diuretic and contractile effects and comparison with Zea mays. J. Ethnopharmacol. 2003; 85: 257-60. [DOI:10.1016/S0378-8741(03)00014-X]
105. Keshtmand Z, Oryan S, Ghanbari A and Khazaei M. Protective effect of hydroalcoholic extract T. terrestris on cisplatin cytotoxicity on sperm viability and count in mice. J. Med. Plant Res. 2014; 4: 66-72.
106. Keshtmand Z, Ghanbari A, Khazaei M and Rabzia A. Protective effect of T. terrestris hydroalcoholic extract against cisplatin-induced apoptosis on testis in mice. Int. J. Morphol. 2015; 33: 279-284. [DOI:10.4067/S0717-95022015000100044]
107. Karimi Jashni H, Malekzadeh Shiravani S and Hoshmand F. The effect of the T. terrestris extract on spermatogenesis in the rat. J. Jahrom. Univ. Med. Sci. 2011; 9: 8-13. [DOI:10.29252/jmj.9.4.8]
108. Abadjieva D and Kistanova E. T. terrestris alters the expression of growth differentiation factor 9 and bone morphogenetic protein 15 in rabbit ovaries of mothers and F1 female offspring. PloS One. 2016; 11: 0150400. [DOI:10.1371/journal.pone.0150400]
109. Esfandiari A, Dehghan A, Sharifi S, Najafi B and Vesali E. Effect of T.terrestris extract on ovarian activity in immature Wistar rat: a histological evaluation. J. Anim. Vet. Adv. 2011; 10: 883-6. [DOI:10.3923/javaa.2011.883.886]
110. Dehghan A, Esfandiari A and Bigdeli SM. Alternative treatment of ovarian cysts with T.terrestris extract: A rat model. Reprod. Domest. Anim. 2012; 47: 12-15. [DOI:10.1111/j.1439-0531.2011.01877.x]
111. Sandeep PM, Bovee TF and Sreejith K. Anti-androgenic activity of nardostachys jatamansi DC and T. terrestris L. and their beneficial effects on polycystic ovary syndrome-induced rat models. Metab. Syndr. Relat. Disord. 2015; 13: 248-54. [DOI:10.1089/met.2014.0136]
112. Gauthaman K, Ganesan AP and Prasad RN. Sexual effects of puncturevine (T. terrestris) extract (protodioscin): an evaluation using a rat model. J. Altern. Complement. Med. 2003; 9: 257-65. [DOI:10.1089/10755530360623374]
113. Neychev VK and Mitev VI. The aphrodisiac herb T.terrestris does not influence the androgen production in young men. J. Ethnopharmacol. 2005; 101: 319-23. [DOI:10.1016/j.jep.2005.05.017]
114. Gauthaman K and Adaikan PG. Effect of T. terrestris on nicotinamide adenine dinucleotide phosphate-diaphorase activity and androgen receptors in rat brain. J. Ethnopharmacol. 2005; 96: 127-32. [DOI:10.1016/j.jep.2004.08.030]
115. Choi S, Choi J and Hyun JS. Effects and mechanism of action of a T.terrestris extract on penile erection. Korean J. Urol. 2013 Mar 1; 54 (3): 183-8. [DOI:10.4111/kju.2013.54.3.183]
116. Mohammed MJ. Biological activity of saponins isolated from T. terrestris (fruit) on growth of some bacteria. Tikrit J. Pure. Sci. 2008; 13: 1-4.
117. Al-Bayati FA and Al-Mola HF. Antibacterial and antifungal activities of different parts of T. terrestris L. growing in Iraq. ‎J. Zhejiang Univ. Sci. B. 2008; 9: 154-9. [DOI:10.1631/jzus.B0720251]
118. Hakemi VM, Goudarzi H, Naseri MS, Kamalinejad M, Jahangiri S and Gholami M. In vitro assessment of Tribulus Terrestri aqueous extract and Benzoxacin fraction against Helicobacter pylori isolates from biopsy samples of Iranian patients. Novelty in Biomedicine (NBM). 2013; 3: 85-90.
119. Deepak M, Dipankar G, Prashanth D, Asha MK, Amit A and Venkataraman BV. Tribulosin and β-sitosterol-D-glucoside, the anthelmintic principles of T. terrestris. Phytomedicine NLM. 2002; 9: 753-6. [DOI:10.1078/094471102321621395]
120. El-Sheikh TM, Al-Fifi ZI and Alabboud MA. Larvicidal and repellent effect of some T. terrestris L., (Zygophyllaceae) extracts against the dengue fever mosquito, Aedes aegypti (Diptera: Culicidae). J. Saudi Chem. Soc. 2016; 20: 13-9. [DOI:10.1016/j.jscs.2012.05.009]
121. Zhang JD, Xu Z, Cao YB, Chen HS, Yan L, An MM, Gao PH, Wang Y, Jia XM and Jiang YY. Antifungal activities and action mechanisms of compounds from T. terrestris L. J. Ethnopharmacol. 2006; 103: 76-84. [DOI:10.1016/j.jep.2005.07.006]
122. Deng Y, Yang L and An SL. Effect of T. terrestris L decoction of different concentrations on tyrosinase activity and the proliferation of melanocytes. Academic J. the First Medical College of PLA. 2002; 22: 1017-9.
123. Sisto M, Lisi S, D'Amore M, De Lucro R, Carati D, Castellana D, La Pesa V, Zuccarello V and Lofrumento DD. Saponins from T. terrestris L. protect human keratinocytes from UVB-induced damage. J. Photochem. Photobiol. 2012; 117: 193-201. [DOI:10.1016/j.jphotobiol.2012.10.002]
124. Orhan I, Şener B, Choudhary MI and Khalid A. Acetylcholinesterase and butyrylcholinesterase inhibitory activity of some Turkish medicinal plants. J. Ethnopharmacol. 2004; 91: 57-60. [DOI:10.1016/j.jep.2003.11.016]
125. Gauthaman K and Ganesan AP. The hormonal effects of T.terrestris and its role in the management of male erectile dysfunction-an evaluation using primates, rabbit and rat. Phytomedicine NLM. 2008; 15: 44-54. [DOI:10.1016/j.phymed.2007.11.011]
126. Talasaz AH, Abbasi MR, Abkhiz S and Dashti-Khavidaki S. T. terrestris-induced severe nephrotoxicity in a young healthy male. Nephrol. Dial. Transplant. 2010; 25: 3792-3. [DOI:10.1093/ndt/gfq457]
127. Glastonbury JR, Doughty FR, Whitaker SJ and Sergeant E. A syndrome of hepatogenous photosensitisation, resembling geeldikkop, in sheep grazing T. terrestris. Aust. Vet. J. 1984; 61: 314-6. [DOI:10.1111/j.1751-0813.1984.tb07135.x]
128. Jadhav AN and Bhutani KK. Ayurveda and gynecological disorders. J. Ethnopharmacol. 2005; 97: 151-9. [DOI:10.1016/j.jep.2004.10.020]
129. Chhatre S, Nesari T, Somani G, Kanchan D and Sathaye S. Phytopharmacological overview of T. terrestris. Pharmacogn. Rev. 2014; 8: 45. [DOI:10.4103/0973-7847.125530]

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