year 19, Issue 76 (11-2020)
J. Med. Plants 2020, 19(76): 46-58 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Tofighi Z, Pirali Hamedani M, Tavakoli S, Tabatabaei M J, Rabei M, Mohtadi S, et al . Screening of Apiaceae fruits discovered natural resources with considerable biological potential. J. Med. Plants 2020; 19 (76) :46-58
URL: http://jmp.ir/article-1-2657-en.html
URL: http://jmp.ir/article-1-2657-en.html
Zahra Tofighi1 
, Mostafa Pirali Hamedani1 , Saeed Tavakoli2 , Mir Javad Tabatabaei1 , Marzieh Rabei1 , Shamim Mohtadi3 , Farnoosh Mirghaffari4 , Maryam Afshani1 , Farhad Kahrizi1 , Behruz Khodabandeloo1 , Saeede Jafari-Nodooshan5 , Mahdieh Shirzad5 , Elahe Motevaseli5 , Saied Goodarzi * 6
, Mostafa Pirali Hamedani1 , Saeed Tavakoli2 , Mir Javad Tabatabaei1 , Marzieh Rabei1 , Shamim Mohtadi3 , Farnoosh Mirghaffari4 , Maryam Afshani1 , Farhad Kahrizi1 , Behruz Khodabandeloo1 , Saeede Jafari-Nodooshan5 , Mahdieh Shirzad5 , Elahe Motevaseli5 , Saied Goodarzi * 6
1- Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
2- Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran
3- International Campus, ICTUMS, Tehran University of Medical Sciences, Tehran, Iran
4- 1Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
5- Department of Molecular Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
6- Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran , goodarzi_s@sina.tums.ac.ir
2- Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran
3- International Campus, ICTUMS, Tehran University of Medical Sciences, Tehran, Iran
4- 1Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
5- Department of Molecular Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
6- Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran , goodarzi_s@sina.tums.ac.ir
Abstract: (2916 Views)
Background: Apiaceae fruits as common spices used for prevention of many chronic diseases including cancer. Objective: The present study compared the biological effects of different fruits from various Apiaceae tribes to compare and find the fraction source(s) with potential characteristics for further investigation including cancer prevention. Methods: Fruits of Apium graveolens L. (celery), Bunium persicum (Boiss.) B.Fedtsch. (black cumin), Petroselinum crispum (Mill.) Fuss (parsley), Pimpinella anisum L. (anise), Trachyspermum ammi (L.) Sprague (ajwain), Coriandrum sativum L. (coriander), Foeniculum vulgare Mill. (fennel), Anethum graveolens L. (dill), Heracleum persicum Desf. ex Fisch., C.A.Mey. & Avé-Lall. (Persian hogweed), Ferula assa-foetida L. (asafoetida), Cuminum cyminum L. (cumin) and Daucus carota L. (carrot) were extracted with 80 % methanol and fractionated by petroleum ether, chloroform, ethyl acetate and methanol, respectively. For different fractions and total extract of all 12 samples, cytotoxicity by brine shrimp test (BST) and MTT assay against cancer and normal cell (foreskin fibroblast cells), antioxidant effects by FRAP, and total phenols by Folin-Ciocalteu method were measured. Results: The general toxicity of ethyl acetate fractions (mean of data) was higher than others in the brine shrimp test (P < 0.05). The most cytotoxic fractions against colon carcinoma (HT-29), breast adenocarcinoma (MDA-MB-231) and alveolar basal epithelial adenocarcinoma (A549) cell lines were from Ammineae and Peucedaneae tribes while fruits fractions with high phenol contents and antioxidant powers were from Ammineae tribe. Conclusion: The Apiaceae fruits have significant biological effects, therefore the isolation of phytochemical compounds from active fractions with cytotoxicity is suggested in future studies.
Type of Study: Research |
Subject:
Pharmacognosy & Pharmaceutics
Received: 2019/09/17 | Accepted: 2020/08/25 | Published: 2020/12/1
Received: 2019/09/17 | Accepted: 2020/08/25 | Published: 2020/12/1
References
1. Fitzmaurice C, Allen C, Barber RM, Barregard L, Bhutta ZA, Brenner H, Dicker DJ, Chimed-Orchir O, Dandona R and Dandona L. Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years for 32 cancer groups, 1990 to 2015: a systematic analysis for the global burden of disease study. JAMA Oncology 2017; 3(4): 524-48. [DOI:10.1001/jamaoncol.2016.5688]
2. Thun MJ, DeLancey JO, Center MM, Jemal A, Ward EM. The global burden of cancer: priorities for prevention. Carcinogenesis 2009; 31(1): 100-10. [DOI:10.1093/carcin/bgp263]
3. Haque MU, Ferdiousi N, Sajon SR. Anticancer agents derived from plant and dietary sources: a review. IJP 2016; 32: 55-66.
4. Cragg GM, Kingston DG, Newman DJ. Anticancer agents from natural products: CRC press; 2011.
5. Kinghorn A, Farnsworth N, Soejarto D, Cordell G, Swanson S, Pezzuto J, Wani M and Wall M. Novel strategies for the discovery of plant-derived anticancer agents. Pharm. Biol. 2003; 41(sup1): 53-67. [DOI:10.1080/1388020039051744]
6. Pimenov MG, Leonov MVe. The genera of the Umbelliferae: a nomenclator: Royal Botanic Gardens, Kew; 1993.
7. Mozaffarian V. A Dictionary of Iranian Plant Names. Tehran: Farhang Moaser Pub, 1996. (In Persian).
8. Amiri MS and Joharchi MR. Ethnobotanical knowledge of Apiaceae family in Iran: A review. Avicenna J. Phytomedicine 2016;6(6):621.
9. Zargari A. Identification method of plant. Tehran: Amirkabir Pub, 1962. Persian.
10. Tofighi Z, Asgharian P, Goodarzi S, Hadjiakhoondi A, Ostad SN, Yassa N. Potent cytotoxic flavonoids from Iranian Securigera securidaca. Med. Chem. Res. 2014; 23 (4): 1718-24. [DOI:10.1007/s00044-013-0773-3]
11. Goodarzi S, Nateghpour M, Asgharian P, Hadjiakhoondi A, Yassa N, Tavakoli S, Mirzaei J, Farivar L, Motevalli Haghi A and Tofighi Z. Antimalarial and cytotoxic activities of roots and fruits fractions of Astrodaucus persicus extract. IJBMS 2017; 20(12): 1318.
12. Goodarzi S, Hadjiakhoondi A, Yassa N, Khanavi M and Tofighi Z. Essential oils chemical composition, antioxidant activities and total phenols of Astrodaucus persicus. IJBMS 2016; 19(2): 159.
13. Tofighi Z, Es-haghi A, Asl MM, Tajic AR, Navai MS, Tavakoli S, Hadjiakhoondi A and Yassa N. Investigation of chemical keys for relationship between plants and their unifloral honeys by hydrodistillation and SPME and biological activities of honeys. Eur. Food Res. Technol. 2014; 238(4): 665-73. [DOI:10.1007/s00217-013-2147-y]
14. Goodarzi S, Tabatabaei MJ, Mohammad Jafari R), Mofasseri M and Tofighi Z. Cuminum cyminum fruits as source of luteolin- 7-O-glucoside, potent cytotoxic flavonoid against breast cancer cell lines. Nat. Prod. Res. 2020; 34(11): 1602-1606. [DOI:10.1080/14786419.2018.1519824]
15. Goodarzi S, Hadjiakhoondi A, Yassa N, Khanavi M and Tofighi Z. New benzodioxole compounds from the root extract of Astrodaucus persicus. IJPR 2016; 15(4): 901-906.
16. Gohari AR, Saeidnia S, Gohari MR, Moradi-Afrapoli F, Malmir M, Hadjiakhoondi A. Bioactive flavonoids from Satureja atropatana Bonge. Nat. Prod. Res. 2009; 23 (17): 1609-14. [DOI:10.1080/14786410902800707]
17. Bussmann R, Malca G, Glenn A, Sharon D, Nilsen B, Parris B, Dubose D, Ruiz D, Saleda J, Martinez M, Carillo L, Walker K, Kuhlman A and Townesmith A. Toxicity of medicinal plants used in traditional medicine in Northern Peru. J. Ethnopharmacol. 2011; 137(1): 121-40. [DOI:10.1016/j.jep.2011.04.071]
18. Shad AA, Shah HU, Bakht J, Choudhary MI and Ullah J. Nutraceutical potential and bioassay of Apium graveolens L. grown in Khyber Pakhtunkhwa-Pakistan. J. Med. Plant. Res. 2011; 5(20): 5160-6.
19. Al-Haadi AMH, Al Rahbi SS, Akhtar MS, Said S, Weli A and Al Riyami Q. Phytochemical screening, antibacterial and cytotoxic activities of Petroselinum crispum leaves grown in Oman. IJPR 2013; 9(1): 61-5.
20. Sharker SM, Shahid IJ. Assessment of antibacterial and cytotoxic activity of some locally used medicinal plants in Sundarban mangrove forest region. Afr. J. Pharm. Pharmacol. 2010; 4(2): 066-9.
21. Hilmi Y, Abushama MF, Abdalgadir H, Khalid A and Khalid H. A study of antioxidant activity, enzymatic inhibition and in vitro toxicity of selected traditional sudanese plants with anti-diabetic potential. BMC Complement. Altern. 2014; 14(1): 149. [DOI:10.1186/1472-6882-14-149]
22. Ksouri A, Dob T, Belkebir A, Lamari L, Krimat S and Metidji H. Total phenolic, antioxidant, antimicrobial activities and cytotoxicity study of wild Anethum graveolens L. Int. J. Pharmacogn. Phytochem. Res. 2015; 7: 1025-32.
23. Moshafi MH, Sharififar F, Dehghan G and Ameri A. Bioassay screening of the essential oil and various extracts of fruits of Heracleum persicum Desf. and rhizomes of Zingiber officinale Rosc. using brine shrimp cytotoxicity assay. IJPR 2010; 8(1): 59-63.
24. Aghaei M, Ghanadian M, Faez F and Esfandiary E. Cytotoxic activities of Euphorbia kopetdaghi against OVCAR-3 and EJ-138 cell lines. J. Herb. Med. Pharmacol. 2015; 4(2): 49-52.
25. Subhadradevi V, Kalathil K, Asokkumar K, Umamaheswari M, Jagannath P. Induction of apoptosis and cytotoxic activities of Apium graveolens Linn. using in vitro models. Middle East J. Sci. Res. 2011; 9(1): 90-94
26. Rakad M, Jumaily A. Evaluation of anticancer activities of crude extracts of Apium graveolens L. Seeds in two cell lines, RD and L20B in vitro. Iraqi J. Cancer Med. Genet. 2010; 3(2): 20-3.
27. Abdel-Reheem MA and Oraby MM. Anti-microbial, cytotoxicity, and necrotic ripostes of Pimpinella anisum essential oil. Ann. Agric. Sci. 2015; 60 (2): 335-40. [DOI:10.1016/j.aoas.2015.10.001]
28. Kadan S, Rayan M and Rayan A. Anticancer activity of anise (Pimpinella anisum L.) seed extract. The Open Nutraceuticals J. 2013; 6(1): 1-5. [DOI:10.2174/1876396001306010001]
29. Vitali LA, Beghelli D, Nya PCB, Bistoni O, Cappellacci L, Damiano S, Lupidi G, Maggi F, Orsomando G and Papa F. Diverse biological effects of the essential oil from Iranian Trachyspermum ammi. Arab. J. Chem. 2016; 9(6): 775-86. [DOI:10.1016/j.arabjc.2015.06.002]
30. Abdel-Hameed E-SS, Bazaid SA, Al Zahrani O, El-Halmouch Y, El-Sayed MM and El-Wakil E. Chemical composition of volatile components, antimicrobial and anticancer activity of n-hexane extract and essential oil from Trachyspermum ammi L. seeds. Orient. J. Chem. 2014; 30(4): 1653-62. [DOI:10.13005/ojc/300425]
31. Firuzi O, Asadollahi M, Gholami M and Javidnia K. Composition and biological activities of essential oils from four Heracleum species. Food Chem. 2010; 122(1): 117-22. [DOI:10.1016/j.foodchem.2010.02.026]
32. Sieniawska E, Świątek Ł, Rajtar B, Kozioł E, Polz-Dacewicz M and Skalicka-Woźniak K. Carrot seed essential oil-Source of carotol and cytotoxicity study. Ind. Crops Prod. 2016; 92: 109-15. [DOI:10.1016/j.indcrop.2016.08.001]
33. Tawil M, Bekdash A, Mroueh M, Daher CF and Abi-Habib RJ. Wild carrot oil extract is selectively cytotoxic to human acute myeloid leukemia cells. Asian Pac. J. Cancer Prev. 2015; 16(2): 761-7. [DOI:10.7314/APJCP.2015.16.2.761]
34. AYDEMIR T and Becerik S. Phenolic content and antioxidant activity of different extracts from Ocimum basilicum, Apium graveolens and Lepidium sativum seeds. J. Food Biochem. 2011; 35(1): 62-79. [DOI:10.1111/j.1745-4514.2010.00366.x]
35. Nickavar B and Abolhasani FA-S. Screening of antioxidant properties of seven Umbelliferae fruits from Iran. PJPS 2009; 22(1): 30-5.
36. Mert A and Timur M. Essential oil and fatty acid composition and antioxidant capacity and total phenolic content of parsley seeds (Petroselinum crispum) grown in Hatay region. Indian J. Pharm. Educ. Res. 2017; 51(3): 437-40. [DOI:10.5530/ijper.51.3s.63]
37. Olgun Ç, Ozkan OE, Guney B, Pattabanoglu ES, Guney K and Gur M. Chemical composition and antimicrobial activity in cold press oil of fennel, Anise, white and black mustard seeds. Indian J. Pharm. Educ. Res. 2017; 51(3): 200-04. [DOI:10.5530/ijper.51.3s.12]
38. Mirzahosseini SM, Noori SAS, Amanzadeh Y, Javid MG and Howyzeh MS. Phytochemical assessment of some native ajowan (Therachyspermum ammi L.) ecotypes in Iran. Ind. Crops Prod. 2017; 105: 142-7. [DOI:10.1016/j.indcrop.2017.04.052]
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
