year 19, Issue 75 (9-2020)                   J. Med. Plants 2020, 19(75): 239-253 | Back to browse issues page


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Nazaryanpour E, Nejad Ebrahimi S. Phytochemical investigation of methanolic extract of Zataria multiflora Boiss.. J. Med. Plants. 2020; 19 (75) :239-253
URL: http://jmp.ir/article-1-2615-en.html
1- Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University G.C., Tehran, Iran
2- Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University G.C., Tehran, Iran , s_ebrahimi@sbu.ac.ir
Abstract:   (396 Views)
Background: Zataria multiflora Boiss. (Lamiaceae) has been found in Iran, Afghanistan, and Pakistan. Z. multiflora called ‘Avishane Shirazi’ in Persian is used as a seasoned in many foods in Iran. The literature survey demonstrated that Z. multiflora has immunostimulant, pain-relieving, antinociceptive, anti-inflammatory, antioxidant, antibacterial, antiviral, antiparasitic, antifungal effects and also widely used in traditional medicine for analgesia, diarrhea, infectious diseases, and gastrointestinal problems. Objective: The subject of this study is performing phytochemical constituents of methanolic extract of Z. multiflora. Methods: The application of various chromatographic techniques such as normal and reverse C18 chromatography let to isolation, purification and identification of several flavonoids. Results: In this investigation, the fractionation of methanol extract of the aerial parts of Z. multiflora led to the isolation and purification of three known flavonoid glycosides namely Luteolin 7-O-glucopyranoside, Apigenin 7-O-rutinoside and Luteolin 7-O-rutinoside whose structures were determined by 1D and 2D-NMR spectroscopic studies, in particular, homo-COSY and hetero (HSQC and HMBC). Conclusion: The results show a methanolic extract of Z. multiflora is a rich source of flavonoids and triterpenoids.
Full-Text [PDF 1851 kb]   (115 Downloads)    
Type of Study: Research | Subject: Pharmacognosy & Pharmaceutics
Received: 2019/08/5 | Accepted: 2020/08/22 | Published: 2020/09/6

References
1. Fazeli M R. Antimicrobial activities of Iranian sumac and Avishan-e Shirazi (Zataria multiflora ) against some food-borne bacteria. Food Control. 2007; 18(6): 646-649. [DOI:10.1016/j.foodcont.2006.03.002]
2. Mahboubi M. Systematic review: The potency of Zataria multiflora Boiss in treatment of vaginal infections. Infectio. 2018; 22(2): 76-83. [DOI:10.22354/in.v22i2.712]
3. Ramezani M, Hosseinzadeh H and Samizadeh S. Antinociceptive effects of Zataria multiflora Boiss fractions in mice. J. Ethnopharmacol. 2004; 91(1): 167-170. [DOI:10.1016/j.jep.2003.12.016]
4. Ariaee N, Ghorbani J, Panahi M, Mohamadi M, Asili J, Ranjbar A, Farid Hoseini R and Jabbari F. Oral administration of Zataria multiflora extract decreases IL-17 expression in perennial allergic rhinitis. Reports of Biochemistry & Molecular Biol. 2018; 6(2): 203-207.
5. Khatibi S A, Misaghi A, Moosavy M H, Akhondzadeh Basti A, Mohamadian S and Khanjari A. Effect of nanoliposomes containing Zataria multiflora Boiss. essential oil on gene expression of Shiga toxin 2 in Escherichia coli O157:H7. J. Appl. Microbiol. 2018; 124(2): 389-397. [DOI:10.1111/jam.13641]
6. Ziaee E, Razmjooei M, Shad E and Eskandari M H. Antibacterial mechanisms of Zataria multiflora Boiss. essential oil against Lactobacillus curvatus. LWT. 2018; 87: 406-412. [DOI:10.1016/j.lwt.2017.08.089]
7. Khazdair M R, Ghorani V, Alavinezhad A and Boskabady M H. Pharmacological effects of Zataria multiflora Boiss L. and its constituents focus on their anti‐inflammatory, antioxidant, and immunomodulatory effects. Fund. Clin. Pharmacol. 2018; 32(1): 26-50. [DOI:10.1111/fcp.12331]
8. Teslov L S and Koretskaya L N. Flavonoids of Campanula persicifolia. I. Chem. Nat. Compd. 1983; 19(6): 749-750. [DOI:10.1007/BF00575193]
9. Svendsen A B. [Isolation of luteolin-7-glycoside from the flowers of Anthriscus sylvestris (L.) Hoffm]. Pharm Acta Helv. 1959; 34(1): 29-32.
10. Borisov M I. Flavonoids of Galium ruthenicum. Chem. Nat. Compd. 1974; 10(5): 677-677. [DOI:10.1007/BF00567877]
11. Shokrzadeh M, Mirzajani F, Javadi I and Modanloo M. Hepatoprotective effect of hydroalcoholic extract of Zataria multiflora Boiss to acute liver damage in mice exposed to carbon tetrachloride-induced toxicity. Adv. Biores. 2017; 8(5): 386-395.
12. Saedi Dezaki E, Mahmoudvand H, Sharififar F, Fallahi S, Monzote L and Ezatkhah F. Chemical composition along with anti-leishmanial and cytotoxic activity of Zataria multiflora . Pharm Biol. 2016; 54(5): 752-758. [DOI:10.3109/13880209.2015.1079223]
13. Sharififar F, Dehghan-Noudeh G, Moshafi M, Ohadi M, Zaman-Basir M, Yazdanpanah E and Yusefian S. Antimutagenic activity of major fractions of Zataria multiflora Boiss by Ames method. Asian J. Pharm. 2015; 9: 195. [DOI:10.4103/0973-8398.160316]
14. Ali M S, Saleem M, Akhtar F, Jahangir M, Parvez M and Ahmad V U. Three p-cymene derivatives from Zataria multiflora. Phytochemistry 1999; 52(4): 685-688. [DOI:10.1016/S0031-9422(99)00259-9]
15. Ali M S, Saleem M, Ali Z and Ahmad V U. Chemistry of Zataria multiflora (Lamiaceae). Phytochemistry 2000; 55(8): 933-936. [DOI:10.1016/S0031-9422(00)00249-1]
16. Mohagheghzadeh A, Shams-Ardakani M, Ghannadi A and Minaeian M. Rosmarinic acid from Zataria multiflora tops and in vitro cultures. Fitoterapia 2004; 75(3-4): 315-321. [DOI:10.1016/j.fitote.2004.01.017]
17. Eftekhar F, Zamani S, Yusefzadi M, Hadian J and Nejad Ebrahimi S. Antibacterial activity of Zataria multiflora Boiss essential oil against extended spectrum β lactamase produced by urinary isolates of Klebsiella pneumonia. Jundishapur J Microbiol. 4(Suppl): 43-49.

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