year 18, Issue 70 (5-2019)                   J. Med. Plants 2019, 18(70): 87-96 | Back to browse issues page


XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Hedaryan A, Hamidpour M, Ayatolahi A, Allah bakhshian Farsiani M. The Synergic Effect of Artemisia Dracunculus (Tarragon) Extract and Aspirin (ASA) on Platelet Function. J. Med. Plants. 2019; 18 (70) :87-96
URL: http://jmp.ir/article-1-2564-en.html
1- Department of Hematology and Blood Banking, School of Allied Medicine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Department of Hematology and Blood Banking, School of Allied Medicine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2- HSCT Research Center-Department of Hematology and Blood Banking, School of Allied Medicine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran , mohsenhp@sbmu.ac.ir
3- Phytochmistry Research Center, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Phytochmistry Research Center, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4- HSCT Research Center-Department of Hematology and Blood Banking, School of Allied Medicine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran, HSCT Research Center-Department of Hematology and Blood Banking, School of Allied Medicine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract:   (930 Views)
Background: Coagulation activity of platelets plays an important role in thrombosis formation, Atherosclerotic plaque establishment and cardiovascular disorders. ASA are using as an anti platelet activity drug for patients with Coronary Artery Disease (CAD). Using of plant extraction as a complementary medicine for these patients (CAD) is mostly recommended by traditional medicine specialist.
Objective: In this study we investigated platelet activity after treatment with extract of Artemisia dracunculus (Tarragon) and it’s synergic with ASA treatment.
Methods: After preparation of platelets from healthy volunteers, platelets confronted with desired concentrations (125-1000 µg/ml) of methanol extract of Artemisia dracunculus (tarragon) and (0.31-1.26 µg/ml) of (ASA) alone and in combination.  The platelet function such as adhesion, aggregation and protein release were assayed on treated platelets and controls.
Results: Our results demonstrated that Tarragon extract significantly effective on adhesion, aggregation and protein release in comparison with healthy volunteers platelets (P≤0.001). The Tarragon extract also raised the anti-platelet activity of ASA on these platelets.
Conclusion: Tarragon extract, either as single agent or combination with ASA, has been able to induce anti-platelet activity. Therefore, it would be suggested to use of the tarragon extract with or without common treatments, i.e. ASA, in treatments of cardiovascular disorders and patients with deep vein thrombosis.
Full-Text [PDF 934 kb]   (399 Downloads)    
Type of Study: Research | Subject: Pharmacology & Toxicology
Received: 2018/01/24 | Accepted: 2018/05/28 | Published: 2019/05/26
* Corresponding Author Address: HSCT Research Center-Department of Hematology and Blood Banking, School of Allied Medicine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

References
1. Sarrafzadegan N, Sadeghi M, Oveisgharan S and Iranipour R. Incidence of cardiovascular diseases in an Iranian population: the Isfahan Cohort Study. Archives of Iranian Medicine 2013; 16 (3): 138.
2. Shimokawa T, Smith W. Prostaglandin endoperoxide synthase. The aspirin acetylation region. J. Biological Chem. 1992; 267 (17): 12387-92.
3. Cooke GE, Liu-Stratton Y, Ferketich AK, Moeschberger ML, Frid DJ, Magorien RD and et al. Effect of platelet antigen polymorphism on platelet inhibition by aspirin, clopidogrel, or their combination. J. the American College of Cardiol. 2006; 47 (3): 541-6. [DOI:10.1016/j.jacc.2005.09.034]
4. Folts JD, Crowell EB and Rowe GG. Platelet aggregation in partially obstructed vessels and its elimination with aspirin. Circulation 1976; 54 (3): 365-70. [DOI:10.1161/01.CIR.54.3.365]
5. Massberg S, Brand K, Gruner S, Page S, Muller E, Muller I and et al. A critical role of platelet adhesion in the initiation of atherosclerotic lesion formation. The J. Experimental Medicine 2002; 196 (7): 887-96. [DOI:10.1084/jem.20012044]
6. Murphy KJ, Chronopoulos AK, Singh I, Francis MA, Moriarty H, Pike MJ and et al. Dietary flavanols and procyanidin oligomers from cocoa (Theobroma cacao) inhibit platelet function. The American J. Clinical Nutrition 2003; 77 (6): 1466-73. [DOI:10.1093/ajcn/77.6.1466]
7. Hamidpour R, Hamidpour S, Hamidpour M and Shahlari M. Cinnamon from the selection of traditional applications to its novel effects on the inhibition of angiogenesis in cancer cells and prevention of Alzheimer's disease, and a series of functions such as antioxidant, Anti cholesterol, anti diabetes, antibacterial, antifungal, nematicidal, acaracidal, and repellent activities. J. Traditional and Complementary Medicine 2015; 5: 66-70. [DOI:10.1016/j.jtcme.2014.11.008]
8. Hamidpour R, Hamidpour S, Hamidpour M, Shahlari M, Sohraby M, Shahlari N and Hamidpour R. Russian olive (Elaeagnus angustifolia L.): From a variety of traditional medicinal applications to its novel roles as active antioxidant, anti-inflammatory, anti-mutagenic and analgesic agent. Journal of Traditional and Complementary Medicine 2017; 7: 24-29. [DOI:10.1016/j.jtcme.2015.09.004]
9. Khorasani MH. Makhzan al adviah. Safa Publication, Tehran. 1992, pp: 583-584.
10. Obolskiy D, Pischel I, Feistel B, Glotov N and Heinrich M. Artemisia dracunculus L. (tarragon): a critical review of its traditional use, chemical composition, pharmacology, and safety. J. Agricultural and Food Chem. 2011; 59 (21): 11367-84. [DOI:10.1021/jf202277w]
11. Shahriyary RY L. Antiplatelet and Antithrombotic Activities of Artemisia dracunculus L. Leaves Extract. Pharmacologyonline 2009; 1 (217): 2-8.
12. Rechinger K. H. and et al. Flora Iranica: Flora des iranischen Hochlandes und der umrahmenden Gebirge, Graz, Austria, 1971, 240-241.
13. Shahriyary L and Yazdanparast R. Inhibition of blood platelet adhesion, aggregation and secretion by Artemisia dracunculus leaves extracts. J. Ethnopharmacol. 2007; 114 (2): 194-8. [DOI:10.1016/j.jep.2007.07.029]
14. Lianne Kokoska, Dana El Masri, Helen Berlie and Candice Garwood. Aspirin prescribing patterns for primary prevention of cardiovascular disease in geriatric patients with diabetes: Survey of prescribers based on experience. Journal of Clinical Gerontology & Geriatrics 2016; 7: 33-36. [DOI:10.1016/j.jcgg.2016.03.006]
15. Eriksson AC and Whiss PA. Measurement of adhesion of human platelets in plasma to protein surfaces in microplates. J. Pharmacological and Toxicological Methods 2005; 52 (3): 356-65. [DOI:10.1016/j.vascn.2005.06.002]
16. Lowry OH, Rosebrough NJ, Farr AL and Randall RJ. Protein measurement with the Folin phenol reagent. J. Biological Chem. 1951; 193 (1): 265-75.
17. Willoughby S, Holmes A and Loscalzo J. Platelets and cardiovascular disease. European journal of cardiovascular nursing: J. the Working Group on Cardiovascular Nursing of the European Society of Cardiol. 2002; 1 (4): 273-88. [DOI:10.1016/S1474-51510200038-5]
18. Nehzati P, Hamidpour M, Bashash D, Nikoogoftar M, Hedari MR and Khadem Mabodi AA. The Detection of HDL receptor on platelet surface in patients with Coronary artery disease (CAD). J. Paramedical Sci. 2017; 8 (1): 33-38.
19. Schrader BJ and Berk SI. Antiplatelet agents in coronary artery disease. Clinical Pharmacy 1990; 9 (2): 118-24.
20. Mohd Nor NH, Othman F, Mohd Tohit ER and Md Noor S. Medicinal Herbals with Antiplatelet Properties Benefit in Coronary Atherothrombotic Diseases. Thrombosis 2016; 2016: 1-7. [DOI:10.1155/2016/5952910]
21. Murphy KJ, Chronopoulos AK, Singh I, Francis MA, Moriarty H, Pike MJ and et al. Dietary flavanols and procyanidin oligomers from cocoa (Theobroma cacao) inhibit platelet function. The American J. Clinical Nutrition 2003; 77 (6): 1466-73. [DOI:10.1093/ajcn/77.6.1466]
22. Ghezelbash B, Amini kafiabad S, Hojjati MT, Hamidpour M, Vaeli Sh, Tabtabae MR and Gharehbaghian A. In Vitro Assessment of Platelet Lesions during 5-day Storage in, Iraninan Blood Transfusion Organization (IBTO) centers. Archives of Iranian Medicine 2015; 18 (2): 114-116.
23. Prakash P, Misra A, Surin WR, Jain M, Bhatta RS, Pal R and et al. Anti-platelet effects of Curcuma oil in experimental models of myocardial ischemia-reperfusion and thrombosis. Thrombosis Res. 2011; (2) 127: 111-118. [DOI:10.1016/j.thromres.2010.11.007]
24. Huang CG, Chu ZL, Wei SJ, Jiang H and Jiao BH. Effect of berberine on arachidonic acid metabolism in rabbit platelets and endothelial cells. Thrombosis Res. 2002; 106 (4-5): 223-7. [DOI:10.1016/S0049-3848(02)00133-0]
25. Tang W, Cao J, Zhang X and Zhao Y. Osmanthus fragrans seeds, a source of secoiridoid glucosides and its antioxidizing and novel platelet-aggregation inhibiting function. Journal of Functional Foods 2015; 14: 337-44. [DOI:10.1016/j.jff.2015.02.001]
26. Teng CM, Chen CC, Ko FN, Lee LG, Huang TF, Chen YP and et al. Two antiplatelet agents from Magnolia officinalis. Thrombosis Res. 1988; 50 (6): 757-65. [DOI:10.1016/0049-3848(88)90336-2]
27. Hamidpour R, Hamidpour S, Hamidpour M, Shahlari M and Sohraby M. Summer Savory: From the Selection of Traditional Applications to the Novel Effect in Relief, Prevention, and Treatment of a Number of Serious Illnesses such as Diabetes, Cardiovascular Disease, Alzheimer 's Disease, and Cancer. Journal of Traditional and Complementary Medicine 2014; 4: 140 - 144. [DOI:10.4103/2225-4110.136540]
28. Banerjee SK and Maulik SK. Effect of garlic on cardiovascular disorders: a review. Nutrition J. 2002; 1: 4-10. [DOI:10.1186/1475-2891-1-4]
29. Obolskiy D, Pischel I, Feistel B, Glotov N and Heinrich M. Artemisia dracunculus L. (tarragon): a critical review of its traditional use, chemical composition, pharmacology, and safety. J. Agricultural and Food Chem. 2011; 59 (21): 11367-84. [DOI:10.1021/jf202277w]
30. Paolo Gresele, Jos'eA. L'opez, Clive P. Page, JosVermylen: Platelets in hematologic and cardivascular disorders. Cambride: Cambridge University Press, 2007, 26-27.
31. Dai Y and Ge J. Clinical use of aspirin in treatment and prevention of cardiovascular disease. Thrombosis 2012; 2012: 1-7. [DOI:10.1155/2012/245037]
32. Lianne Kokoska, Dana El Masri, Helen Berlie and Candice Garwood. Aspirin prescribing patterns for primary prevention of cardiovascular disease in geriatric patients with diabetes: Survey of prescribers based on experience. J. Clinical Gerontology & Geriatrics 2016; 7: 33-36. [DOI:10.1016/j.jcgg.2016.03.006]

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


© 2020 All Rights Reserved | Journal of Medicinal Plants

Designed & Developed by : Yektaweb