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:: Volume 4, Issue 36 (12-2010) ::
JMP 2010, 4(36): 106-116 Back to browse issues page
Study of Acute and Chronic Antihyperglycemic Activity of Methanolic Extract of Salvia mirzayanii Rech. & Esfand. in Rats
Abstract:   (3309 Views)
Background: In folk medicine, there are many uses of useful effects of some medicinal plants for treatment of disease. In traditional medicine of Kerman province, Salvia mirzayanii Rech. & Esfand. (Lamiaceae) or Mor-e-Porzo applies for treatment of diabetes mellitus. Literature reviews showed another species of Salvia had antidiabetic effects. Objective: In this study anti hyperglycemic activities of this plant were evaluated. Methods: Eleven group (n=7) of male white rats (six normal and five diabetic) used. Diabetes induced by IP injection of streptozocin (STZ) (64 mg/kg). Diabetes was allowed to develop in these STZ treated rat over of 24h, and animals treated by 50, 100, 200, 400 mg/kg of the dried metanolic extract by IP injection for 24 hours and 400 mg/kg for 12 days. Finally, surgery carried out on these animals and liver and pancreas studied histopathologically. For statistic, used ANOVA with Turkeys' post hoc. Results: The maximal reduction in the blood glucose concentration of the fasted rats occurred at extract 400 mg/kg dose of extract. This dose (400 mg/kg) significantly reduced the blood glucose concentrations (p<0.01). On the other hand, histopathological studies showed this extract could repair and increase blood supply of pancreatic cells of these diabetic animals. Conclusion: Methanolic extract of S. mirzayanii could reduce blood glucose of these diabetic animals and its considerable effects on damaged pancreatic tissue, persuade the complemented studies and investigation on this plant.
Keywords: Salvia mirzayanii, Diabetes, Streptozocin, Rat, Methanolic extract
Full-Text [PDF 848 kb]   (1367 Downloads)    
Type of Study: Research | Subject: Pharmacognosy
Received: 2014/10/20 | Accepted: 2014/10/20 | Published: 2014/10/20
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Study of Acute and Chronic Antihyperglycemic Activity of Methanolic Extract of Salvia mirzayanii Rech. & Esfand. in Rats. JMP. 2010; 4 (36) :106-116
URL: http://jmp.ir/article-1-252-en.html

Volume 4, Issue 36 (12-2010) Back to browse issues page
فصلنامه علمی پژوهشی گیاهان دارویی Journal of Medicinal Plants
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