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:: Volume 4, Number 36 (12-2010) ::
JMP 2010, 4(36): 87-95 Back to browse issues page
Optimization of Extraction Method of Hyoscine from Hyoscyamus niger L.
R Ghafarzadegan1, P Khadiv-parsi2, F Khalighi-Sigaroodi3, M Pirali Hamedani4, Z Kadkhoda5, Sh Rezazadeh *6
1- (M.Sc.) Department of Pharmacognosy and Pharmaceutics, Institute of Medicinal Plants, ACECR
2- (Ph.D.) Department of Chemical Engineering, Faculty of Engineering, University of Tehran
3- (Ph.D.) Department of Pharmacognosy and Pharmaceutics, Institute of Medicinal Plants, ACECR
4- (Ph.D.) Department of Medicinal Chemistry, Faculty of Pharmacy and Medicinal Plants Research Center, Tehran University of Medical Sciences
5- (M.Sc. Student) Department of Pharmacognosy and Pharmaceutics, Institute of Medicinal Plants, ACECR
6- (Ph.D.) Department of Pharmacognosy and Pharmaceutics, Institute of Medicinal Plants, ACECR , shrezazadeh@yahoo.com
Abstract:   (2421 Views)
Background: Hyoscyamus niger L. from Solanaceae is an important pharmacological plant which contains tropane alkaloids. tropane alkaloids constitute one distinct group of secondary metabolites of the Solanaceae. Hyoscyamus species are rich source of tropane alkaloids, mainly hyoscyamine and hyoscine (scopolamine), which are widely used for their mydriatic,antispasmodic, anticholinergic, analgesic and sedative properties. Therefore determine of optimized method is necessary for extraction of hyoscine from Hyoscyamus niger L. Objective: The purpose of this research is determine of optimized conditions for extraction of hyoscine from Hyoscyamus niger L. Methods: Three factors, temperature, extraction time and mesh size of plant were studied using three level box-behnken design. the hyoscine content were measured by Gas chromatograph, Younglin Acm 6000 model. Results: The results showed that the best conditions for extraction of hyoscine from Hyoscyamus niger L. is Ultrasonic extraction in 43 C, 130 min and 45 mesh size. Conclusion: It can be concluded that in order to efficient extraction of hyoscine from Hyoscyamus niger L., special conditions should be considered.
Keywords: Hyoscyamus niger L, Solanaceae, Hyoscine, Alkaloid
Full-Text [PDF 461 kb]   (660 Downloads)    
Type of Study: Research | Subject: Medicinal Chemistry
Received: 2014/10/19 | Accepted: 2014/10/19 | Published: 2014/10/19
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Ghafarzadegan R, Khadiv-parsi P, Khalighi-Sigaroodi F, Pirali Hamedani M, Kadkhoda Z, Rezazadeh S. Optimization of Extraction Method of Hyoscine from Hyoscyamus niger L.. JMP. 2010; 4 (36) :87-95
URL: http://jmp.ir/article-1-250-en.html
Volume 4, Number 36 (12-2010) Back to browse issues page
فصلنامه علمی پژوهشی گیاهان دارویی Journal of Medicinal Plants
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