year 19, Issue 74 (6-2020)                   J. Med. Plants 2020, 19(74): 335-342 | Back to browse issues page


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nematshahi M, mirhamidi M, asadi A. The effect of dried barberry root on the symptoms of opiate withdrawal syndrome in patients undergoing methadone maintenance therapy-double-blind clinical trial. J. Med. Plants. 2020; 19 (74) :335-342
URL: http://jmp.ir/article-1-2478-en.html
1- Faculty of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran
2- Sabzevar University of Medical Sciences, Sabzevar, Iran
3- Sabzevar University of Medical Sciences, Sabzevar, Iran , a.asadi.mm.1384@gmail.com
Abstract:   (616 Views)
Background: Drug dependence is one of the biggest problems all over the world. Health custodians have suggested many ways to quit smoking. One of these ways is to stop the drug from taking alternative medicines. Various drugs, such as herbs and chemists, are used to stop the drug and to treat symptoms associated with it. Some herbal medicines have less side effects and are equally effective than chemical drugs such as methadone that cause liver failure. One of these herbs is the dried root of barberry. Objective: The aim of this study was to reduce the daily dose of methadone to reduce its side effects and supplement barberry. Methods: This study was a double-blind clinical trial that was conducted on clients referred to addiction treatment centers in Sabz. Of the eligible individuals, 40 were randomly selected and randomly assigned (two groups of 20). Patients were all in the stage of treatment stability (methadone and methadone dose on a weekly basis). The intervention group was treated with methadone syrup and barberry self-made capsules and the control group received methadone and placebo syrup for 2 months. Results: The findings of the study showed that there was a significant difference between the effectiveness of Barberry compared with placebo on pain, diarrhea, temptation, nasal congestion caused by drug withdrawal (P < 0.001). However, no significant difference was seen between the two groups in terms of effect on anorexia induced cracks. Conclusion: Barberry extract can be complementary to methadone to help reduce the symptoms of a withdrawal syndrome.
Full-Text [PDF 746 kb]   (295 Downloads)    
Type of Study: Research |
Received: 2019/03/6 | Accepted: 2019/06/3 | Published: 2020/07/21

References
1. Zargari A. Medicinal plants (6th ed). University of Tehran Press. 2016, 574-8.
2. Hyman SE and Malenka RC. Addiction and the brain: the neurobiology of compulsion and persistence. Nat. Rev. Neurosci. 2001; 2(10): 695-703. [DOI:10.1038/35094560]
3. De Vries TJ and Shippenberg TS. Neural systems underlying opiate addiction. J. Neurosci. 2002; 22(9): 3321-5. [DOI:10.1523/JNEUROSCI.22-09-03321.2002]
4. Cami J and Farre M. Drug addiction. N. Engl. Med. 2003; 349(10): 975-86. [DOI:10.1056/NEJMra023160]
5. Nestler EJ. Molecular basis of long-term plasticity underlying addiction. Nat. Rev. Neurosci. 2(2): 119-28. [DOI:10.1038/35053570]
6. Robinson TE and Berridge KC. Addiction. Annu Rev. Psychol. 2013; 54: 25-53. [DOI:10.1146/annurev.psych.54.101601.145237]
7. Makri A and Norouzi A. The guide on methadone maintenance treatment in addicts. Irsa Publications. 2013.
8. Center for Substance Abuse Treatment. Substance Abuse Treatment for Persons with Co-Occurring Disorders. Treatment Improvement Protocol (TIP) Series. 2015.
9. Talebi Kaysari, Fatemeh; Milladi, Hussein; Effect of Medicinal Plants on the Treatment of Morphine Addiction; Review of Laboratory Studies. Journal of North Khorasan University of Medical Sciences 2012; 4: 157-64. [DOI:10.29252/jnkums.4.5.S5.157]
10. Vlogg Studola J. Medicinal Plants, 1997, p: 3-231-6.
11. Mohammad Nemat Shahi, Atefeh Asadi, Elham Behnam Talab, Mahbobeh Nemat Shahi. Clinical Study The Impact of Saffron on Symptoms of Withdrawal Syndrome in Patients Undergoing Maintenance Treatment for Opioid Addiction in Sabzevar Parish in 2017; Hindawi Advances in Medicine; Volume 2017, Article ID 1079132, 5 pages [DOI:10.1155/2017/1079132]
12. Dehghan G and et al. The study of mode of action of Berberis vulgaris in the reduce of morphine withdrawal syndrome signs in the male mouse. Abst of the 10 th Iranian Congress of Physiology and Pharmacology. 2013.
13. Tavakoli M, Sahaf R, Farhudian A, Bakhtavar Y and Farhadi M. The influence of detoxification on the quality of life in substance addicts lives with 40-65 years of age referring to the charity. Salmand-e - Iranian J. 2012; 6: 34-40. (Persian)
14. Salehi M; Mikehlf A, Barkatin Majid. The effect of amitriptyline on the control of acute withdrawal symptoms of opiates. Journal of Semnan University of Medical Sciences 2005; 6 (3): 195-200.
15. Hojjati H, Aloustani S, Akhondzadeh G, Heidari B and Sharif-Nia H. Study of mental health and its relation with quality of life in addicts. J. Shahid Sadoughi Uni. Med. Sci. 2010; 18: 207-14. (Persian)
16. Nassiriasl Marjan. Effect of "Release" and "Burberry" in toxic and non-toxic doses in reducing the symptoms of morphine withdrawal syndrome in mice; http://crs.qums.ac.ir/webdocument/load.action?webdocument_code=1000&masterCode=14000455#h4.
17. Esmaeili MH, Azhdarea H, haghdoost H, sofiabadea M. Effect of orexin receptor-1 agonist and antagonist microinjection into the ventral tegmental area on morphine withdrawal syndrome. J. Qazvin Univ. Med. Sci. 2013; 17(3): 4-11.

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