year 19, Issue 75 (9-2020)                   J. Med. Plants 2020, 19(75): 4-16 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Moosavyzadeh A, Jafari Hajati R, Ghaffari F, Khatami S, Vakili Zahir N, Naseri M. From Datura stramonium L to Hab-o-shefa: manuscript, animal and clinical studies for the treatment of addiction. J. Med. Plants. 2020; 19 (75) :4-16
1- Traditional Medicine Clinical Trial Research Center, Shahed University, Tehran, Iran
2- School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3- Traditional Medicine Clinical Trial Research Center, Shahed University, Tehran, Iran ,
Abstract:   (480 Views)
Background: Due to the lack of drug dependence prevention processes and the low effectiveness of treatment for the withdrawal of addiction and undesirable side effects of synthetic drugs, moving towards the use of reverse pharmacology to produce a less costly, effective, and low-risk drug is inevitable. Objective: Considering the long history of traditional medicine in Iran in the field of diagnosis and treatment of diseases, including addiction, this study was done by looking at the original manuscript of traditional Persian Medicine (PM), animal studies and clinical trial of the effects of Daturra stramonium and Hab-o-shefa for treatment of opiate addiction. Methods: This paper includes three sections: the study of PM textbooks, animal studies and clinical trials based on research conducted. Results: In the study of PM texts, two main pharmacologic ways to treat opioid habits have been described, graduation and replacement. In the research done Daturra’s effect on pharmacological withdrawal syndrome in male rats was significantly more than methadone. Hab-o-shefa’s toxicology studies did not show any side effects and tissue damage. Animal studies did not show a significant difference in the total score between the methadone group and Hab-o-shefa group. Clinical studies of Hab-o-shefa on the withdrawal syndrome of opioid dependent patients showed the effect of this product on controlling depression and Signs of deprivation compared to placebo and clonidine. The effect of Hab-o-shefa as a preservative in people with opioid abuse reduced craving, anxiety, and depression over time. Conclusion: The results of our studies showed the effectiveness of hab-o-shefa in all phases of addiction treatment. However, further studies are needed to confirm these findings.
Full-Text [PDF 873 kb]   (298 Downloads)    
Type of Study: Review | Subject: Traditional Pharmacy & Traditional Medicine
Received: 2019/03/5 | Accepted: 2019/06/16 | Published: 2020/08/31

1. Tobinick EL. The value of drug repositioning in the current pharmaceutical market. Drug News Perspect. 2009; 22 (2): 119-25. [DOI:10.1358/dnp.2009.22.2.1303818]
2. World Health Organization, The promotion and development of traditional medicine: report of a WHO meeting [held in Geneva from 28 November to 2 December 1977]. 1978.
3. World health Organization. WHO traditional medicine strategy. 2002-2005. 2002.
4. Naseri M and Health Village. 3nd ed. Traditional and Integrative Medicine Press. Tehran. 2009, pp: 25-30.
5. Ghaffari F, Naseri M, Asghari M and Naseri V. Abul- hasan al-tabari: A review of his views and works. Arch Iran Med. 4(17): 299-301.
6. Naseri M. Persian traditional medicine and develop it using the World Organization Guidelines. Daneshvar Med. 2004; 52: 53-66.
7. Surh Y. Reverse pharmacology applicable for botanical drug development: inspiration from the legacy of traditional wisdom. J. Tradit. Complement. Med. 2011; 1: 5-7. [DOI:10.1016/S2225-4110(16)30051-7]
8. Patwardhan B, Vaidya AD and Chorghade M. Ayurveda and natural products drug discovery. Curr. Sci. 2004; 86: 789-99.
9. Patwardhan B and Mashelkar RA. Traditional medicine-inspired approaches to drug discovery: can Ayurveda show the way forward? Drug Discov. Today 2009; 14: 804-11. [DOI:10.1016/j.drudis.2009.05.009]
10. Aliasl J, Barikbin B, Khoshzaban F, Naseri M, Sedaghat R, Kamalinejad M and et al. Effect of Arnebia euchroma ointment on post-laser wound healing in rats. J. Cosmet. Laser Ther. 2015; 17(1): 41-5. [DOI:10.3109/14764172.2014.968583]
11. Heidari MR, Soltanpour A, Naseri M and Kazemnejad A. The effect of lemon balm (Melissa Officinalis) on depression in patients after coronary artery bypass graft. Iranian J. Cardio. Nursing 2015; 4(2): 36-43.
12. Hajiheydari MR, Yarmohammadi ME, Izadi P, Jafari F, Emadi F, Emaratkar E, Abtahi SHR, Zargaran A and Naseri M. Effect of Nepeta bracteata Benth on allergic rhinitis symptoms: a randomized double blind clinical trial. J. Res. Med. Sci. 2017; 28: 122-8. [DOI:10.4103/jrms.JRMS_316_17]
13. Ahmadi A, Mohagheghi M, Karimi M, Seyed Ali Golestanha and Naseri M. Anticancer effects of HESA-A in patients with metastatic colon cancer. Integr. Cancer Ther. 2009; 1(8): 71-4. [DOI:10.1177/1534735408327995]
14. Ahmadi A, Mohagheghi M, Karimi M, Golestanha SA, Naseri M, Faghihzadeh S and Habibi G. Therapeutic effects of HESA-A in patients with end-stage metastatic cancers. Integr. Cancer Ther. 2010; 9(1): 32-5. [DOI:10.1177/1534735409357934]
15. Nazari S M, Naseri M, Mokri A, Davati A and Kamalinejad M. Hab-o Shefa (an Iranian traditional medicine compound) in withdrawal syndrome and its effects in acute detoxification of opiates addict: A randomized, double blind, clinical trials. J. Med. Plant. Research. 2013; 7(22): 1628-1635.
16. Naseri M. Evaluation of Antiepileptic drugs in Traditional Iranian Medicine [Thesis]. Shahid Beheshti university. Faculty of Medicine.Tehran. 1993.
17. Pasalar M, Lankarani KB, Mehrabani D, Tolide-I HR and Naseri M. The effect of Descureania sophia L. and Prunus domestica L. in prevention of constipation among iranian Hajj Pilgrims, Saudi Arabia. Res. J. Pharm. Biol. Chem. Sci. 2013; 2(4): 1195-204.
18. Khodaie SA, Kamalinejad M, Emadi F and Naseri M. Prioritization of effective Materia Medica on diabetic foot ulcer in Persian medicine. Daneshvar Med. 2018; 25(132): 45-54.
19. Bart G. Maintenance medication for opiate addiction: the foundation of recovery. J. Addic. Dis. 2012; 31: 207-25. [DOI:10.1080/10550887.2012.694598]
20. Talebi Keyasari F and Miladi Gorji H. Effect of Medicinal plants in the treatment of opioid addiction; Review of Laboratory Studies. J. North Khorasan Uni. Med. Sci. 2014; 2(165) 167-165. [DOI:10.29252/jnkums.4.5.S5.157]
21. Nazari SM, Naseri M, Mokri A, Davati A and Kamalinejad M. Hab-o Shefa (an Iranian traditional medicine compound) in withdrawal syndrome and its effects in acute detoxification of opiates addict: A randomized, double blind, clinical trials. J. Med. Plants Res. 2013; 7(22): 1628-35.
22. Alam-mehrjerdi Z, Noori R and Dolan K. Opioid use, treatment and harm reduction services: the first report from the Persian Gulf region. J. Sub. Use. 2016; 21(2): 217-23.
23. Arzani M and Qarabadin Qaderi. 2nd ed. Iran University of Medical Science. Tehran: 2007, p: 18.
24. Razi B. Kholasah Altajarob.1nd ed.Tehran University of Medical Science Press. Tehran: 2002, p: 623.
25. Nazari M. Explanation of Addiction and its treatment methods in Traditional Iranian Medicine and investigation of effect of Hab-o Shefa on control of withdrawal symptoms of opioid dependency: A Randomized, Double blind, controlled clinical trial in acute detoxification [PhD thesis]. Shahed University. Tehran. Iran 2012.
26. Shirazi E. Book of Afyonieh. Corrected by Choopani R, Panahi V and Sadeghpour A. Traditional Iranian Medicine Press. Tehran: 2011.
27. Razi B. Kholasah Altajarob. Corrected by Shams Ardekani M, Mohagheghzadeh E, Faridi P and Abolhasanzadeh Z. Tehran University Press. Tehran. 2008, p: 261.
28. Khalili M, Naseri M and Naderi Gh. Atyabi, The effect of Datur stramonium seed on the behavioral patterns of withdrawal syndrome withdrawal syndrome. Daneshvar Med. 2012; 16(79): 25-32.
29. Moosavyzadeh A, Mokri A, Farzaneh Ghaffari F, Faghihzadeh S, Azizi H, Jafari Hajati R, Mohsen Naseri M, Hab-o Shefa, a persian medicine compound for maintenance treatment of opioid dependence: randomized placebo-controlled clinical trial. J. Alt. Complement. Med. 2020; 26(5): 1-8. [DOI:10.1089/acm.2019.0390]
30. Moosavyzadeh A, Ghaffari F, Mosavat SH, Zargaran A, Mokri A, Faghihzadeh S and Naseri M. The medieval Persian manuscript of Afyunieh: the first individual treatise on the opium and addiction in history. J. Integ .Med. 2018; 16(2): 77-83. [DOI:10.1016/j.joim.2018.02.004]
31. Nazari M, Naseri M, Mokri A,Ghafari F, Davati A and Kamalinejad M. Opium and treatment of addiction to it from the perspective of Traditional Persian Medicine. Medic History J. 2011; 3(9): 133-150.
32. Hao W and Zhao MA. comparative clinical study of the effect of WeiniCom, a Chinese herbal compound, on alleviation of withdrawal symptoms and craving for heroin in detoxification treatment. J. Psychoactive Drugs 2000; 32(3): 277-84. [DOI:10.1080/02791072.2000.10400450]
33. Darvishzadeh-Mahani F, Esmaeili-Mahani S, Komeili G, Sheibani V and Zare L. Ginger (Zingiber officinale Roscoe) prevents the development of morphine analgesic tolerance and physical dependence in rats. J. Ethnopharm. 2012; 141(3): 901-7. [DOI:10.1016/j.jep.2012.03.030]
34. Trannum A, Shamsi Sh and zaman R. Acute toxicity study of a polyherbal Unani formulation Habbe shifa in experimental animal model. Ind. J. Trad. Knowledge. 2014; 13(1): 171-4.
35. Nazari M, Naseri M, Mokri A, Khalili M, Hasheminejad SA and Tavakoli Rad T. Evaluation of the effect of oral administration of Hab-o Shefa on morphine withdrawal syndrome in rats: a behavioral study. J. Basic. Clinic. Pathophysio. 2013; 1(2): 45-9.
36. Nazari SM, Naseri M, Mokri A, Davati A and Kamalinejad M. Hab-o Shefa (an Iranian traditional medicine compound) in withdrawal syndrome and its effects in acute detoxification of opiates addict: A randomized, double blind, clinical trials. J. Medicin. Plants Res. 2013; 7(22): 1628-35.
37. Pierce TL, Hope W and Raper C. The induction and quantitation of methadone dependence in the rat. J. Pharmacol. Toxicol. Methods 1996; 3: 137-46. [DOI:10.1016/S1056-8719(96)00108-6]
38. Mujassam M. Abstinence syndrome attenuating effect of Habbe Shifa in morphine dependent animals (thesis). National Institue of Unani Medicine. Banglore. 2012.
39. Inturrisi CE. Pharmacology of methadone and its isomers. Minerva Anestesiol. 2005; 7-8: 435-7.
40. Schurr A, Rigor BM, Strong R and Gottesfeld Z. The cholinergic system in rat striatum during morphine tolerance and dependence. Life. Sci. 1983; 33: 2521-5. [DOI:10.1016/0024-3205(83)90161-3]
41. Contreras E, Tamayo L and Quijada L. Partial inhibition of abstinence stndrome in morphine tolerant-dependent mice folloing pharmacological denervation. Arch. Int. Pharmaco. Ther. 1987; 1: 124-33.
42. Thomson PDR for herbal medicine. Physician's Desk Reference. 4 th ed. 2008, Vol: 1. P. 365, 482.
43. Wang X, Li J, Huang M, Kang L and Hu M. A study on Fu-Yuan Pellet, a traditional chinese medicine formula for detoxification of heroin addictions. Am. J. Drug Alcohol Abuse. 2009; 35(6): 408-11. [DOI:10.3109/00952990903377146]
44. Kang L, Li B, Gao L, Li S, Wang D, Hu M and Li J. Tai-Kang-Ning, a Chinese herbal medicine formula, alleviates acute heroin withdrawal. Am. J. Drug Alcohol Abuse 2008; 34(3): 269-76. [DOI:10.1080/00952990802013409]
45. Shi J, Xu GZ, Liu TT, Wang X, Shen LY, Li J, Hao W, Chen HX, Li SX and Lu L. A comparative clinical study of the effects of the traditional Chinese medicine Jinniu capsules and lofexidine on acute heroin withdrawal symptoms. Am. J. Drug Alcohol Abuse 2008; 34(6): 792-800. [DOI:10.1080/00952990802491563]
46. Mokri A, Chawarski MC, Taherinakhost H and Schottenfeld RS. Medical treatments for opioid use disorder in Iran: a randomized, double‐blind placebo‐controlled comparison of buprenorphine/naloxone and naltrexone maintenance treatment. Addiction J. 2016; 111(5): 874-82. [DOI:10.1111/add.13259]
47. Esmaeili HR, Ziaddinni H, Nikravesh MR, Baneshi MR and Nakhaee N. Outcome evaluation of the opioid agonist maintenance treatment in Iran. Drug Alcohol Rev. 2014; 33(2): 186-93. [DOI:10.1111/dar.12112]
48. Assadi SM, Radgoodarzi R and Ahmadi-Abhari SA. Baclofen for maintenance treatment of opioid dependence: a randomized double-blind placebo-controlled clinical trial. BMC Psych. 2003; 3(1): 16. [DOI:10.1186/1471-244X-3-16]
49. Krupitsky E, Nunes EV, Ling W, Illeperuma A, Gastfriend DR and Silverman BL. Injectable extended-release naltrexone for opioid dependence: a double-blind, placebo-controlled, multicentre randomised trial. Lancet. 2011; 377(9776): 1506-13. [DOI:10.1016/S0140-6736(11)60358-9]
50. Lin SK. Pharmacological means of reducing human drug dependence: a selective and narrative review of the clinical literature. Brit. J. Clinic. Pharmaco. 2014; 77(2): 242-52. [DOI:10.1111/bcp.12163]
51. O'Brien CP. Anticraving medications for relapse prevention: a possible new class of psychoactive medications. Am. J. Psych. 2005; 162(8): 1423-31. [DOI:10.1176/appi.ajp.162.8.1423]
52. Witkin JM, Overshiner C, Li X, Catlow JT, Wishart GN, Schober DA and et all. M1 and M2 muscarinic receptor subtypes regulate antidepressant-like effects of the rapidly acting antidepressant scopolamine. J. Pharmaco. Experim. Ther. 2014; 351(2): 448-56. [DOI:10.1124/jpet.114.216804]
53. Drevets WC and Furey ML. Replication of scopolamine's antidepressant efficacy in major depressive disorder: a randomized, placebo-controlled clinical trial. Biol. Psychiatry 2010; 67(5): 432-8. [DOI:10.1016/j.biopsych.2009.11.021]
54. Furey ML, Khanna A, Hoffman EM and Drevets WC. Scopolamine produces larger antidepressant and antianxiety effects in women than in men. Neuropsychopharmac. 2010; 35(12): 2479-88. [DOI:10.1038/npp.2010.131]

Add your comments about this article : Your username or Email:

Send email to the article author

© 2020 All Rights Reserved | Journal of Medicinal Plants

Designed & Developed by : Yektaweb