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:: Volume 2, Issue 38 (10-2011) ::
J. Med. Plants 2011, 2(38): 102-116 Back to browse issues page
Antifungal Efficacy of Myrtus communis Essential Oils on Oral Candidiasis in Immunosupressed Rats
T Najib – Zadeh1, MH Yadegari *2, H Naghdi Badi3, A Salehnia4
1- School of Medical Sciences, Tarbiat Modares University
2- School of Medical Sciences, Tarbiat Modares University , yadegarm@modares.ac.ir
3- Department of Cultivation & Development, Institute of Medicinal Plants, ACECR
4- Khorraman Pharmaceutical Co., Lorestan
Abstract:   (4088 Views)
Background: Characterization and application of medicinal plants essential oils may be useful in counteracting drug-resistant infections. Objective: To evaluate the antifungal efficacy of myrtle (Myrtus communis L.) essential oils on oral candidiasis in immunosuppressed rats. Methods: The essential oil of myrtle was extracted by hydrodistillation method and its components and content were recognized by GC and GC-MS apparatuses. The MIC of essential oil and nystatin was determined by broth macrodilution procedures. Thirty five rats weighting 200 ± 20g was randomly arranged in 5 treatment groups including: (1) placebo group, (2) myrtle essential oil-treated group (2-fold MIC), (3) nystatin-treated group, (4) Non-immunosupressed-infected group, and (5) Immunosupressed-noninfected group. The strong pathogen was isolated from the vaginal secretion of a patient suffering from acute vaginitis. Infection level and therapeutic effects was evaluated by microbiological, histopathological methods and clinical examinations. Results: Alpha-pinene, limonene, linalool, alpha-terpineol and linaleol acetate were main components of the essential oil. The MIC of the essential oil and nystatin was 2 mg/ml and 4µg/ml against Candida albicans, respectively. Microbiological and histopathological evaluations indicated that the essential oil of Myrtus communis had significant activity against C. albicans (p < 0.01). Of course, there was still limited area of infection in some region of mocusa in the back of tongues in which it can remain dormantly and result in illness appearing. Conclusion: The treatment by myrtle essential oil at concentration of 2 fold MIC was not sufficient to remove completely oral candidiasis in immunosupressed rats. Therefore, it should be evaluated the doses of essential oil more than 2-fold MIC in the formulation in order to the completely eradication of candidiasis.
Keywords: Oral candidiasis, Candida albicans, Myrtus communis, Essential oil, Microbiological, Histopathological evaluations
Full-Text [PDF 303 kb]   (1308 Downloads)    
Type of Study: Research | Subject: Mycology
Received: 2014/10/15 | Accepted: 2014/10/15 | Published: 2014/10/15
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Najib – Zadeh T, Yadegari M, Naghdi Badi H, Salehnia A. Antifungal Efficacy of Myrtus communis Essential Oils on Oral Candidiasis in Immunosupressed Rats. J. Med. Plants. 2011; 2 (38) :102-116
URL: http://jmp.ir/article-1-217-en.html


Volume 2, Issue 38 (10-2011) Back to browse issues page
فصلنامه علمی پژوهشی گیاهان دارویی Journal of Medicinal Plants
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