year 10, Issue 38 (5-2011)                   J. Med. Plants 2011, 10(38): 95-101 | Back to browse issues page

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Miladi - Gorji H, Vafaei A, Bageri A. To Investigate the Effect of Portulaca oleracea L. and Melissa officinalis L. Extract on Sleeping Time in Mice. J. Med. Plants. 2011; 10 (38) :95-101
1- Department and Physiology Research Center, Semnan University of Medical Sciences ,
2- Department and Physiology Research Center, Semnan University of Medical Sciences
3- Faculty of Medicine, Semnan University of Medical Sciences Semnan
Abstract:   (5263 Views)
Background: Portulaca oleracea (PO) and Melissa officinalis (MO) overgrow in the different parts of Iran. In previous studies, systemic administration of the extract of PO and MO induces antinociceptive, anxiolytic and anticonvulsive, sedative effects in animals. Objective: This study was designed to evaluate different doses of the aqueous decoction extracts of PO and MO on sleeping time on mice. Methods: Male albino mice (25 - 30 g) were used in this study. The animals divided to control (saline), PO (25, 50 and 75 mg/kg) and MO (5, 10 and 25 mg/kg) groups (by IP injection). For measuring of sleeping time we used Angle method. Results: The results have shown that three doses of PO and two doses of 10 and 25 MO significantly increased sleeping time (p=0.000). Conclusion: This finding showed that PO and MO may be play important role on the modulation of sleeping time.
Full-Text [PDF 189 kb]   (1573 Downloads)    
Type of Study: Research | Subject: Pharmacology & Toxicology
Received: 2014/10/15 | Accepted: 2014/10/15 | Published: 2014/10/15
* Corresponding Author Address: Department of Physiology, Physiology Research Center, Semnan University of Medical Sciences, Semnan, Iran Tel: +98-231-3354170 - 3, Fax: +98-231-3354161

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