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Rashki Kemmak M, Gol A. Preventive and Protective Effects of Garlic on Serum Albumin Levels and Diabetic Nephropathy Improvement of Male Rats. J. Med. Plants 2011; 10 (40) :39-47
URL: http://jmp.ir/article-1-180-en.html

Background: Diabetic nephropathy (DN) is a common cause for end-stage renal disease in developing countries. The characteristic features of this disease are persistent albuminuria and reduction of serum albumin. Objective: We aimed to demonstrate the preventive effect of garlic juice on damages in DN in rats with streptozotocin (STZ)-induced diabetes. Methods: Forty male rats (250±20) were divided into 5 groups as follows: 1- Group normal (N) 2- Group Normal+Garlic (N+G) 3- Diabetic (D) 4- Group diabetic+garlic before (D+Gb) (receiving garlic before STZ injection) 5- Group diabetic+garlic after (D+Ga) (receiving garlic after STZ injection). Garlic juice was given by gavage (1ml/100gBW). Results: Diabetic rats showed an increase in serum glucose, urinary volume, and urinary albumin to creatinine ratio (Alb: Cr), urinary albumin excretion, and decrease in serum albumin. Garlic juice significantly attenuated the diabetes-induced increase in albumin clearance and urinary albumin excretion in the diabetic rats. The diabetic group receiving garlic before STZ injection showed more amelioration in complications than that receiving it after STZ injection. Conclusion: In this study for the first time we showed that administration of garlic juice could play a preventive role on diabetic nephropathy in rats.