Curcumin is a natural compound that obtains from the rhizome of turmeric plant. It has a wide range of pharmacological and therapeutic effects via various molecular and cellular mechanisms. With regards to pharmacological effects and drug use of curcumin, the study of its pharmacological properties for using in clinical trials is essential and need. The most important therapeutic effects of curcumin include: antioxidant, anti- inflammatory and anticancer properties. Although, no side effect and toxicity of curcumin has been reported, but the application of this compound as a supplemental therapy in treatment regimes for various diseases is taking into consideration. The clinical studies of curcumin combined with chemotherapy drugs demonstrated that the curcumin increases the effectiveness of drugs and decrease of side effects of chemotherapy drugs. The aim of this work is the review of all studies which conducted on pharmacological and therapeutic properties of curcumin.