Introduction: There is need to more research because of extent drug trade in country and diversity of proposal cures such as non pharmacological ways including exercise and herbal medicine.

The aim of the study: The aim of this study was study of synchronic effect of Curcumin and swimming training on depression in morphine addicted male mice.

Methods: In an experimental research, 40 Albino NMRI male mice with 19- 21 gr were selected as subjects and they were divide randomly to care groups of control, morphine, swim training, Curcumin, swim training+ Curcumin. Subjects swam 60 min/day, 5 days/week for 1 week with receiving Curcumin. They were taken morphine (2.5 mg/ml/kg) for 5 days. Therefore FST were done and after 10 days this test was taken again.

Results: training increased swimming time, but it had no significant effect on immobility and climbing. At this period, Curcumin supplementation caused increasing the time of climbing and no alteration in immobility and swimming times. Curcumin supplementation with swim training increased immobility time and decreased swimming time, but it had no significant effect on climbing time.

Conclusion: the results of this research showed that morphine consumption didn’t cause depression. Also, combination of Curcumin supplementation and swim training hasn’t caused depression decreasing in morphine consumption term.