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Darabi P, Tavakoli-far B, Vaezi G, Keramati K. Effects of Intracerebroventricular Injection of Alcoholic Extract of hawthorn (Crataegus melanocarpa carpa) Leaves on Fear Behavior in Presence Pentylenetetrazole (PTZ) in Adult Male Rat. J. Med. Plants 2012; 11 (44) :202-211
URL: http://jmp.ir/article-1-134-en.html

Background: In traditional medicine “Crataegus melano carpa” is one of the medicinal plants that has many therapeutic effects. One of them is its effect on nerveous system.
Objective: Evaluation of Intracerebroventricular (ICV) injection of alcoholic extract of “Crataegus melano carpa” leaves on fear behavior in presence pentylenetetrazole (PTZ) in adult male rat.
Methods: Animals were divided into 3 groups: experimental, saline and, pentylenetetrazole (PTZ) 20 mg/kg as positive control (I.P). In the experimental group, the animals received 4000 µg/Rat alcoholic extract of “Crataegus melano carpa” leaves (ICV) and PTZ (I.P). Then plus maze was used for evaluation of the fear. Open arm entries percentage (%OAE) and open arm time percentage (%OAT) were evaluated.
Results: The results show that intracerebroventricular (ICV) injection of alcoholic extract of “Crataegus melano carpa” leaves increased %OAE and %OAT significantly (p<0.05).
Conclusion: We concluded that alcoholix extract of “Crataegus melano carpa” is effective on fear reduction in presence pentylenetetrazole (PTZ) in adult male rat.