[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 4, Number 44 (12-2012) ::
JMP 2012, 4(44): 202-211 Back to browse issues page
Effects of Intracerebroventricular Injection of Alcoholic Extract of hawthorn (Crataegus melano carpa) Leaves on Fear Behavior in Presence Pentylenetetrazole (PTZ) in Adult Male Rat
P Darabi *1, B Tavakoli-far2, Gh Vaezi, K Keramati
1- M.Sc. Alborz University of Medical Science , parisa.darabi01@gmail.com
2- Ph.D.
Abstract:   (2836 Views)

Background: In traditional medicine "Crataegus melanocarpa" is one of the medicinal plants

that has many therapeutic effects. One of them is its effect on nerveous system.

Objective: Evaluation of Intracerebroventricular (ICV) injection of alcoholic extract of

 

"crataegus melanocarpa" leaves on fear behavior in presence pentylenetetrazole (PTZ) in adult

male rat.

Methods: Animals were divided into 3 groups: experimental, saline and, pentylenetetrazole

(PTZ) 20mg/kg as positive control (I.P). In the experimental group, the animals received

4000 μg/Rat alcoholic extract of "Crataegus melanocarpa" leaves (ICV) and PTZ (I.P). Then plus

maze was used for evaluation of the fear. Open arm entries percentage (%OAE) and open arm

time percentage (%OAT) were evaluated.

Results: The results show that intracerebroventricular (ICV) injection of alcoholic extract of

 

"Crataegus melanocarpa" leaves increased %OAE and %OAT significantly (p<0.05).

 

Conclusion: We concluded that alcoholic extract of "Crataegus melanocarpa" is effective on fear

reduction in presence pentylenetetrazole (PTZ) in adult male rat.

Keywords: Crataegus Melanocarpa, Pentylenetetrazole, Memory and Learning, Fear
Full-Text [PDF 294 kb]   (777 Downloads)    
Type of Study: Research | Subject: Physiology
Received: 2014/10/4 | Accepted: 2014/10/4 | Published: 2014/10/4
Send email to the article author

Add your comments about this article
Your username or email:

Write the security code in the box >



XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Darabi P, Tavakoli-far B, Vaezi G, Keramati K. Effects of Intracerebroventricular Injection of Alcoholic Extract of hawthorn (Crataegus melano carpa) Leaves on Fear Behavior in Presence Pentylenetetrazole (PTZ) in Adult Male Rat. JMP. 2012; 4 (44) :202-211
URL: http://jmp.ir/article-1-134-en.html
Volume 4, Number 44 (12-2012) Back to browse issues page
فصلنامه علمی پژوهشی گیاهان دارویی Journal of Medicinal Plants
Persian site map - English site map - Created in 0.051 seconds with 794 queries by yektaweb 3463