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:: Volume 4, Number 56 (12-2015) ::
JMP 2015, 4(56): 105-114 Back to browse issues page
Quantitative Assessment of Hyoscyamine and Scopolamine Tropane Alkaloids in Root and Shoot of Hyoscymaus spp. from Iran
F Fattahi1, A Shojaeiyan *2, H Askari3, H Naghdi Badi4, Ayyari M5, Mokhtassi-Bidgoli A6, Palazon Barandela J7
1- (Ph.D. student) 1- Horticultural Sciences - Medicinal Plants, Department of Horticultural Sciences, Agriculture Faculty, Tarbiat Modares University, Tehran, Iran
2- (Ph.D.) 2- Department of Horticultural Sciences, Agriculture Faculty, Tarbiat Modares University, Tehran, Iran , Shojaeiyan@modares.ac.ir
3- (Ph.D.) 3- Department of Biotechnology Faculty of Energy Engineering and New Technologis, Shahid Beheshti University, Tehran, Iran
4- (Ph.D.) 4- Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran
5- (Ph.D.) 2- Department of Horticultural Sciences, Agriculture Faculty, Tarbiat Modares University, Tehran, Iran
6- (Ph.D.) 5- Department of Agronomy. Agriculture faculty. Tarbiat Modares University, Tehran, Iran
7- (Ph.D.) 6- Department of Plant Physiology. Pharmacy Faculty. University of Barcelona. Barcelona. Spain
Abstract:   (1593 Views)

Background: Different species of Hyoscymaus are rich sources of tropane alkaloids, especially hyoscyamine and scopolamine. These compounds medicinally are important tropane alkaloids that exclusively are produced by plants.

Objective: Evaluation of hyoscyamine and scopolamine tropane alkalolids content in shoots and roots of Hyoscyamus species including H. kotschyanus, H. squarrosus, H. pusillus,
H. kurdicus, H. scoparia, H. othocarpus.

Methods: This research was done as a factorial experiment in a completely randomized design with three replications. Seeds of Hyoscyamus species were grown in growth room under 25 C° temperature and 16/8 h light/dark period conditions. Samples of dried shoot and underground organs of 6 to 7 month plants were extracted and then content of hyoscyamine and scopolamine was evaluated by HPLC.

Results: Hyoscyamine and scopolamine content in H. orthocarpus were more than the other species and total of these two compounds in H. orthocarpus (15.81 mg/gr dry weight) was approximately 2 times more than H. kotschyanus (7.45 mg/gr dry weight) and manifold of the other studied species. Hyoscyamine was the main compound in H. orthocarpus. The least amount of hyoscyamine and scopolamine was in H. pusillus.

Conclusion: H. orthocarpus and H. kotschyanus because of higher content of hyoscymine and scopolamine with more studies can be used as rich sources of these tropane alkaloids in pharmacy industries.

Keywords: Hyoscyamus spp, Hyoscyamine, Scopolamine, Tropane alkaloid
Full-Text [PDF 318 kb]   (616 Downloads)    
Type of Study: Research | Subject: gardening
Received: 2016/02/13 | Accepted: 2016/02/13 | Published: 2016/02/13
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Fattahi F, Shojaeiyan A, Askari H, Naghdi Badi H, Ayyari M, Mokhtassi-Bidgoli A et al . Quantitative Assessment of Hyoscyamine and Scopolamine Tropane Alkaloids in Root and Shoot of Hyoscymaus spp. from Iran. JMP. 2015; 4 (56) :105-114
URL: http://jmp.ir/article-1-1230-en.html
Volume 4, Number 56 (12-2015) Back to browse issues page
فصلنامه علمی پژوهشی گیاهان دارویی Journal of Medicinal Plants
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