سال 19، شماره 73 - ( English 1398 )
سال 19 شماره 73 صفحات 62-37 |
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Ahmadian-Attari M M, Eslami S, Dargahi L, Noorbala A A. Common herbal treatments for senile dementia in ancient civilizations:
Greco-Roman, Chinese, Indian, and Iranian. J. Med. Plants 2020; 19 (73) :37-62
URL: http://jmp.ir/article-1-2328-fa.html
URL: http://jmp.ir/article-1-2328-fa.html
احمدیان عطاری محمدمهدی، اسلامی صولت، درگاهی لیلا، نوربالا احمدعلی. درمانهای گیاهی مشترک برای زوال عقل سالمندی در تمدنهای باستانی: تمدن یونان و روم، چین، هند و ایران. فصلنامه گياهان دارویی. 1398; 19 (73) :37-62
محمدمهدی احمدیان عطاری1 
، صولت اسلامی2 ، لیلا درگاهی3 ، احمدعلی نوربالا* 4
، صولت اسلامی2 ، لیلا درگاهی3 ، احمدعلی نوربالا* 4
1- مرکز تحقیقات گیاه درمانی و طب مکمل مبتنی بر شواهد، دانشگاه علوم پزشکی البرز، کرج، ایران
2- مرکز تحقیقات پروبیوتیک و مکمل‌های غذایی، دانشگاه علوم پزشکی البرز، کرج، ایران
3- مرکز تحقیقات نوروبیولوژی، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران
4- بخش روان‌تنی بیمارستان امام خمینی، دانشگاه علوم پزشکی تهران، تهران، ایران ،noorbala1@tums.ac.ir
2- مرکز تحقیقات پروبیوتیک و مکمل‌های غذایی، دانشگاه علوم پزشکی البرز، کرج، ایران
3- مرکز تحقیقات نوروبیولوژی، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران
4- بخش روان‌تنی بیمارستان امام خمینی، دانشگاه علوم پزشکی تهران، تهران، ایران ،
چکیده: (8273 مشاهده)
مقدمه: زوال عقل سالمندی شایع‌رین نوع زوال عقل با هزینه‌های قابل ملاحظه اجتماعی و اقتصادی است. ماهیت این بیماری پیچیده است و درمانهای رایج نتوانسته‌اند همه جنبه‌های این بیماری را پوشش دهند. اخیراً تمرکز بر ترکیبات طبیعی مخصوصاً موادی که سابقه مصرف سنتی دارند در دستور کار مطالعات علمی است. هدف: هدف این مطالعه بررسی درمانهای مشترک زوال عقل در طب باستانی یونان، طب سنتی چین، هند و ایران با تمرکز بر گیاهانی است که حداقل در دو تمدن به این عنوان ذکر شده باشد. روش بررسی: پایگاه اسکوپوس و منایع دست اول طب سنتی برای واژگان منتخب این تحقیق جستجو شدند. سپس گیاهان مشترکی که حداقل در دو طب سنتی برای زوال عقل کاربرد داشتند مورد بررسی مواد مؤثره و مکانیسم اثر دارویی قرار گرفتند. نتایج: گیاهان وج، سنبل هندی، شیرین‌بیان، آمله، بلادر، بلیله و زنجبیل در طب‌های سنتی پیشگفت برای زوال عقل تجویز می‌شده‌اند. مطالعات فارماکولوژیک نشان می‌دهد این گیاهان اثر ضد زوال عقل خود را از طریق مهار استیل کولین استراز، مهار NMDA، اثر آنتی‌اکسیدانی، ضد التهابی، ضد آپوپتوزی و جلوگیری از تشکیل پلاک بتا-آمیلوئیدی بروز می‌دهند. همچنین، شانزده ماده فعال دارویی ضد آلزایمری شامل آلفا و بتا-آسارون، دزوکسو-نارکینول آ، نارکینول بی، گلابریدین، لیکوئیریتیژنین، امبلیکانین آ و بی، چبولاژیک اسید، زینجیپائین، 6-جینجرول، 6-شوگائول و چند ماده دیگر در این گیاهان شناسایی شده‌اند. نتیجه‌گیری: طب سنتی چین، هند و ایران می‌توانند نقش مکمل در پیشگیری و درمان زوال عقل سالمندی ایفا کنند. شواهد علمی از آثار سنتی ضد آلزایمر درمانهای آنها پشتیبانی می‌کند.
نوع مطالعه: مروری |
موضوع مقاله:
داروسازی سنتی و طب سنتی
دریافت: 1397/8/4 | پذیرش: 1397/12/7 | انتشار: 1399/3/17
دریافت: 1397/8/4 | پذیرش: 1397/12/7 | انتشار: 1399/3/17
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