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Showing 3 results for استامینوفن

R Jajvandian , P Bahary , A Phany, N Mahdavy Shahry , Dashtizad M ,
year 5, Issue 18 (5-2006)
Abstract

Objective: Turmeric (Curcuma longa L.) has protective effects on Liver and digestive system. Based on the importance of poultry industry and toxic agents that induce disease in broilers, we studied the protective effect of Turmeric on liver. Methods: Pre treatment with turmeric (1 mg/KgB.W) for 14 days and treatment with acetaminophen (650 mg/kgB. W) and turmeric for 30 days were conducted. Determination of daily body weight gain and hystopathological studies on liver, smallintestine and forestomach were conducted. Results: pre treatment with turmeric resulted in better rate of growth and improvement of small intestine mocus. The side effect of acetaminophen was reversed after treatment with the extract. Conclusion: it is suggested that addition of Turmeric to poultry nutrient is very useful for protection against toxins. That reffers to curcumin.

M Hojat , Fr Hamadanizadeh , F Sarhangi, E Motahedian , H Sahraei,
year 7, Issue 28 (11-2008)
Abstract

Background: Headache is the most common complaint in patients. In order to alleviate the headache, specialists have recommended different chemical and non-chemical drugs. Acetaminophen is one of the widespread analgesic drugs used for headache relief. On the other hand, tea (Camellia thea Lk.) is the most common drink for the most people world wide. In addition, previous studies indicated that tea’s alkaloids seem to inhibit the acetaminophen metabolism. Objective: The present study aims to assess the effect of tea consumption on effectiveness of acetaminophen. Methods: In order to test the hypothesis, 120 patients suffered from headache referred to the Shaheed Motahari general hospital in Jahrom (Fars province, south of IRAN) were requested to take part in a single blind clinical trial study. 58 patients as the case group have received a glass of tea and after 20 min they had taken a 325 mg acetaminophen tablet. 62 patients as the control group received a glass of warm water and 20 min later had the same drug. Pain intensity was twice measured by a self-report questionnaire. The first one was 15 min before the tea or water consumption and the second, 60 min after receiving the acetaminophen. Results: Results showed that: consumption of tea before taking acetaminophen significantly reduced the pain intensity comparing with the control group. In addition, with respect to sex and age, no significant differences were found between the groups. Conclusion: It can be concluded that consumption of tea before taking acetaminophen may accelerate the analgesic effectiveness of the drug.

Af Dadkhah, Gh Khalaj, F Fatemi, S Dini, S Hesaraki, S Naij, M Babaei, Hr Attaran,
year 15, Issue 60 (10-2016)
Abstract

Background: Acetaminophen as a common antipyretic drug, in overdoses, is poisonous for the liver.

Objective: The current study aimed to assess the protective effects of Ferula (F.) gummosa essential oils against the liver toxicity of acetaminophen in rats.

Methods: 80 male Wistar rats were randomly divided into 16 groups (n=5). Negative control group received only DMSO and the positive control group received acetaminophen 500 mg/kg b.w i.p. The treatment groups received F. gummosa essential oils (100 and 200 mg/kg b.w) i.p immediately after acetaminophen administration. The blood were collected for estimating the values of total antioxidant of plasma (FRAP) and liver enzymes; alanin teransferase (ALT), aspartate teransferase (AST), and alkaline phosphatase (ALP). Also, a piece of liver was used for determining of glutathione (GSH), lipid peroxidation (LP) concentrations, the activity of glutathione s-transferase (GST) and histopathological studies. 

Results: The data showed that F. gummosa essential oil modulate significantly the changes in the levels of GSH, GST and FRAP as well as the liver enzymes and lipid peroxidation compared to negative control group. Furthermore, the histopathological findings of the liver tissue was confirmed the biochemical results.

Conclusion: The essential oil extracted from F. gummosa possessed antioxidant activity which protects the liver against the toxic effects of acetaminophen.



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