Background: Dysmenorrhea is one of the most common gynecological complaints in women. The use of Zataria multiflora is recommended in traditional medicine for the relief of dysmenorrhea. Objective: The purpose of the study was to determine the efficacy of Zataria multiflora essential oil for the treatment of primary dysmenorrhea. Methods: This study was a randomized, double – blind, placebo- controlled, clinical trail. 108 adolescents 18 - 24 years, who complained of primery dysmenorrhea were graded mild, moderate and severe on the basis of a verbal multidimensional scoring system. Subjects were randomly assigned into three groups: The first group (N=36) received placebo, the second group (N=36) received the essence of Zataria multiflora 1% and the third group (N=36) received the essence of Zataria multiflora 2%. The trial medicines were administered as soon as pain feeling (25 drops q 4h orally). Subjects evaluated for 3 cycles. Intensity of pain was reported by using a 10-point linear analog technique and Multi Dimensional System. Statistical analyses were performed by the paired T– test and Chi – Square and ANOVA test. The accepted level of significant was p < 0.05. Results: After of intervention, Mean of dysmenorrhea severity was decreased from 7.8+/-1.6 to 7.4 +/- 1.8 in placebo group, from 7.3+/-1.5 to 3.1 +/- 1.5 in Zataria multiflora essential oil 1% group and from 7.5+/-1.7 to 2.6 +/- 1.4 in Zataria multiflora essential oil 2% group respectively. A significant difference was observed between two treated groups, and placebo (P<0/001). The evaluation of treatment is significantly improved in the treated groups compared with placebo, but it was not different between treated groups. In the placebo group, 66.7% of patients needed to use other medication to relief symptoms, but in 1% and 2% Zataria multiflora essential oil treated groups, 41.8% and 39.9% of patients needed to use other medications, respectively (p< 0/008). Conclusions: The essence of Zataria multiflora can be used as a effective herbal drug for primary dysmenorrhea.

Background: Because of importance and outbreak of dysmenorrhea and that’s effect on life of 50% populations in the world (women), this study was done. Objective: This study was performed to evaluate therapeutic effects of Stachys lvandulifolia on primary dysmenorrhea in 18 - 25 years old women. Methods: This research was a double - blind randomized clinical trial, that had been done on 50 women in 18 - 25 years old and 50 - 60 kg in weight that suffering from primary dysmenorrhea. Intensity of pain was evaluated by visual analog scale (VAS). Stachys lvandulifolia was given them as a traditional method. Such as 10g of powder of stachys flowers, three times a day, for 5 days (2 days before pain up to 3 days after pain). Then they were followed up for three cycles. Duration and intensity of pain and side effect of drugs was evaluated after utilization. Statistical analysis was performed using t-test, chi-square. Results: After Utilization, duration of pain was statistically significant (p=0/000). Conclusion: It can be concluded that the use of Stachys lvandulifolia on traditional method is effective in curing primary dysmenorrhea and it has no side effects resulting. In addition, it is effective on pattern of pain and increases tolerance.

Dysmenorrhea is called "primary" when there is no specific abnormality and "secondary" when the pain is caused by an underlying gynecological problem. It is believed that primary dysmenorrhea occurs when hormone-like substances called "prostaglandins" produced by uterine tissue trigger strong muscle contractions in the uterus during menstruation. However, the level of prostaglandins does not seem to have anything to do with how strong a woman's cramps are. Some women have high levels of prostaglandins and no cramps, whereas other women with low levels have severe cramps. This is why experts assume that cramps must also be related to other things (such as genetics, stress, and different body types) in addition to prostaglandins. Secondary dysmenorrhea may be caused by endometriosis, fibroid tumors, or an infection in the pelvis. In this article we focus on herbal medicine in the treatment of primary dysmenorrheal

Background: Primary dysmenorrhea is a common and frequently disabling condition among women in adolescence and reproductive age. Based on results of large epidemiological studies, it is estimated that over a half of the population of young women suffers from dysmenorrhea. Some people are now seeking alternatives to conventional medicine such as herbal drugs.
Objective: This study was designed to compare the analgesic effect of Valeriana officinalis with Mefenamic acid in treatment of primary dysmenorrhea.
Methods: A randomized, controlled trial was undertaken among 39 female aged 16 to 42 who suffered from primary dysmenorrhea referred to gynecology clinic in Hajar hospital, Shahrekord, Iran.  The participants were randomly divided into two groups: Valeriana officinalis (n=18) and Mefenamicacid (n=21). In intervention group, the patients took350mg  Valerian three times a day, and in mefenamic group, the patients took 250 mg Mefenamic three times a day for three days(for three cycles), starting from the onset of bleeding or pain. Participants were followed for three cycles. Main outcome measures was the mean of pain severity at 3 months which recorded by Visual Analogue Scale.
Results: There were no significant differences in age, menstural duration, menstural interval, and pain severity score at the beginning of the study in two groups (P>0.05). After the intervention, findings of the study revealed statistically significant reductions in mean of pain score in Valeriana officinalis (P<0.001) and Mefenamic acid (P<0.001) groups, but this reduction had not significant differences between two groups (P>0.05).
Conclusion: Results shows that valerian has positive effect on treatment of primery dysmenorrheal. More clinical trials are needed to establish the efficacy of Valeriana officinalis in primary dysmenorrhea.