Background: Noscapine is an isoquline alkaloid from opium with antitussive effect. Our previous study indicated that noscapine is non-competitive inhibitor of bradykinin. Objective: Since bradykinin and histamine contribute in inflammatory processes, the effect of noscapine on rat hind paw inflammation induced by bradykinin and histamine was investigated. Method: Paw edema induced by subplantar injection of 0.1 ml bradykinin solution (3nmol/paw) or 1% histamine solution. Noscapin (1, 5 and 10 mg/kg) and indomethacin (10mg/kg) as standard anti-inflammatory drug were administered intraperitoneally (i.p) one hour before injection of bradykinin or histamine. The thickness of hind paw was measured with a caliper and compared to control groups before and 15, 30, 60, 90, 120 minutes after injection of bradykinin and before and 60, 120, 180 minutes after injection of histamine. Results: Administration of noscapine significantly suppressed the inflammation. The maximum anti-inflammatory effect of noscapin observed at dose of 5 mg/kg against bradykinin and at dose of 10mg/kg against histamine. So this activity of noscapine was similar to activity of indomethacin. Conclution: Our results showed that noscapine has anti-inflammatory effect on inflammatory response of rat hind paw. This effect, was comparable to the anti-inflammatory effect of indomethacin.

Background: Bradykinin has effects on histaminic response,vessels seepage,cellular reproduction,causing fever, pain and coughs caused by ACE controllers (3,4,6). Noscapin has controlled Bradykinins contractional effects on guinea pigs trachea and rats vazodofran (5,6). noscapin stops the secondary effects of eskimi in brains edema, with antagonizing the responses caused by Bradykinin (3,4,8). Objective: considering that opium’s alkaloids act as agonist of peptide systems like ankephalins and RAS, its interesting to know the effects of this alkaloids and among them Noscapine on B3 Bradykinin receptors on smooth muscle guinea pig trachea? Method: All variables are reported as mean and standard deviation.We have used pair test and the informations were processed by Excel, Statistical analysis with ANOVA (LSD) SPSS 9. Results: we took diagrams in to consideration and indicated that the contract ional effect of Bradykinin decreased dependent on density, in presence of three different amount of noscapines concentration. In this study we could demonstrate that noscapine interact with Bradykenin as a non competitive antagonist.