Background: Juglans regia leaves have antioxidant effects and have been used in Iranian traditional medicines for its hypoglycaemic properties in the treatment of diabetes. Objective: This study is designed to evaluate the antidiabetic effects of Juglans regia leave’s methanolic extract (JRLME). Methods: Alloxan-induced diabetic male wistar rats have treated with JRLME at doses of 250 mg/kg and 500 mg/kg for three weeks and its effects investigated on various biochemical parameters such as postprandial blood glucose level (short term and long term treatment by JRLME), oral glucose tolerance, Total cholesterol (TC), Triglyceride (TG), LDL-cholesterol, HDL-cholesterol and VLDL levels, enzymatic activities of superoxide dismutase (SOD), glutathione peroxidase (GPX) and catalase (CAT) using commercial kits. Results: The obtained results showed a decrease (31%) in the blood glucose level within 3 to 8 hours and also a significant decrease (44%) at the end of three weeks of feeding JRLME. The JRLME also decreased markedly TG (14%) and TC (7.6%) levels in blood serum. In addition, antioxidant effect of JRLME was determined from elevated GPX, SOD and CAT activities by 22, 12 and 9%, respectively, as compared to diabetic control group (DC). However, the data about CAT activity was not significant as compared to diabetic control group (DC). Conclusion: We concluded that Juglans regia leaves have multifunctional ameliorating effects in diabetic metabolic conditions.

Background: Type 2 diabetes is a global health problem and a major cause of illness. Exercise, diet and medication are the three pillars in the treatment of type 2 diabetes. Objective: The aim of the present study was to investigate the effect of aerobic training combined with green tea hydroalcoholic extract consumption on blood glucose and lipid profile on diabetic rats. Methods: Diabetes was induced in 40 male Wistar rats by intraperitoneal injection of 50 ml/kg streptozocin. After two weeks the diabetic rats with fasting blood glucose of 150 to 300 mg/dl were divided into 4 groups of 10 rats each and named as: aerobic exercise, aerobic exercise with green tea, green tea, and control. Aerobic exercise was performed as running on Treadmill for 5 days a week daily for 30-90 minutes with Treadmill speed of 18 -24 meters per minute. Green tea extract (100 mg/kg) was gavages once a day for 5 weeks. At baseline and endpoint fasting blood glucose, cholesterol, HDL-c, LDL-c and triglyceride levels were determined in all groups. Results: Fasting blood glucose level decreased significantly in all groups but triglyceride and cholesterol decreased in aerobic exercise and aerobic exercise + green tea groups at end point compared with baseline and also compared with control group. Fasting blood LDL-c level significantly decreased and HDL-c level significantly increase, in aerobic exercise and aerobic exercise with green tea at end point compared with baseline and also compared with control and green tea group. Conclusion: Aerobic exercise favorably affects glucose and lipid profile and in combination with green tea it has synergistic effects.

Objective: The aim of the present study was to investigate the effects of resistance training combined with green tea extract consumption on blood glucose and lipid profile in diabetic rats.

Methods: Forty male Wistar diabetic rats aged 5 months and weights 290 ± 20 were divided into 4 groups named as: resistance training, resistance training + green tea, green tea and control. The resistance training and resistance training + green tea groups engaged in exercise for 5 weeks with three times per week moving up the ladder with weight hanging their tail. Green tea extract
(100 mg/kg) was gavaged once a day for 5 weeks. Forty eight hours after the last training session and green tea gavages, the fasting blood samples was collected for determination of blood glucose, cholesterol, LDL-C, HDL-C and triglyceride levels.

Results: Fasting blood glucose level significantly decreased in all three groups compared with control group, where as triglyceride, cholesterol and LDL-C level significantly decrease in resistance training + green tea group compared to control group.