S Parvardeh , M Nassiri-Asl , Mt Mansouri , H Hosseinzadeh ,
year 4, Issue 14 (5-2005)
Abstract
Background: Thymoquinone, the major constituent of Nigella sativa seeds, is a biologically active compound, which possesses several pharmacological effects. Objective: The aim of the present study was to evaluate the anticonvulsant effect of thymoquinone through intracerebroventricular (i.c.v.) injection. Method: The anticonvulsant effects of thymoquinone, the major constituent of Nigella sativa seeds, were investigated using pentylenetetrazole (PTZ)-induced seizure model. Results: In PTZ-induced epileptic seizures, the i.c.v. injection of thymoquinone (200 and 400 mol) prolonged the onset and reduced the duration of tonic-clonic seizures. The protective effect of thymoquinone against lethality was 45% and 50% in the mentioned doses, respectively. In this study, flumazenil (1 nmol, i.c.v.) reversed the anticonvulsant activity of thymoquinone. Also, pretreatment with naloxone (10 mol, i.c.v.) antagonized the prolongation of tonic-clonic seizure latency, as well as reduction in seizure duration both induced by thymoquinone (200 mol, i.c.v.). Conclusion: These results indicate that thymoquinone may possess anticonvulsant activity probably through an opioid receptor-mediated increase in GABAergic tone.
M Niakan, Sr Miri , M Naseri, M Karimi, S Mansouri,
year 5, Issue 19 (9-2006)
Abstract
Background: The anti-microbial effect of plants has been suggested from old years. New researches in this field confirm such property of applications. Objective: In this study, anti-microbial effects of Nigella sativa seed oil cold extract against two strains of Staphylococcus aureus was evaluated, and the Minimum Inhibitory Concentration (MIC) of Nigella sativa L. (NS) was compared with relevant antibiotics. Methods: Detection of MIC in NS oil cold extract was performed using broth dilution method. The original extract was prepared in 0.5%, 0.25%, 0.06% and 0.03% concentrations by serial dilution. S. aureus strains (ATCC 1112 and 2572) were grown in TSB media to 0.5 MC Farland standard concentrations and each 0.01 dilution of microorganism suspension above was transferred to the drug dilution. Tubes were incubated overnight at 35 °C. The sensitivity of the bacteria were defined by Disk Diffusion (kirby-bauer) Method and Antibiogram disks made by Difco Inc . The obtained values were compared with the effects of the extract. Results: MIC for S. aureus ATCC-2572 and S. aureus ATCC-1112 were found 1/16 and 1/10, respectively. It was revealed by performing in vitro sensitivity tests for the two strains that NS oil can affect the bacterial pure form in 0.125% and 0.26% concentrations. Conclusion: It is suggested that the anti-microbial effect of NS oil extract is comparable with antibiotics such as CXM, CEC, MAN, CAZ. We recommend experimental use of Nigella sativa L. to control some of bacterial infections.
Maryam Iranzadasl, Parvin Mansouri, Mohammad Kamalinejad, Narjes Gorji,
year 19, Issue 73 (3-2020)
Abstract
Background: Skin cancers are the most prevalent type among the white with an increasing trend of incidence around the world and Iran. Scientific developments in diagnosing these cancers and using screening methods and utilizing treatment methods have contributed to the relative control of the cancer. Hence, it is necessary to consider other suggested approaches of complementary and traditional medicine to prevent and treat these cancers. Objective: The purpose of this review is to investigate the alternative remedies from the Persian Medicine; as a pioneer medical approach with an old history. Methods: In this review study, the medical textbooks of the golden era of Persian Medicine (9th to 19th centuries AD), i.e., the times of Razes and Avicenna, were explored and interesting opinions on skin malignancies were found. In addition, the phrase “skin cancers” was searched in databases like PubMed, Science Direct, Scopus, and Google Scholar. The gleaned data were analyzed and compared. Results: The ancient Persian scholars knew the cancers and were forerunners in the description, classified, etiology and treatment of skin cancers. This study explored interesting opinions like nutrition and black bile clearance on skin malignancies treatment, also found no contradictory views between the Persian and modern medicine on the topic of skin cancers. Conclusion: Paying attention to the neglected areas can makes useful theories and hypotheses fore achievement to new more effective and safe remedies.
