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Study of the Effects of Urtica dioica Ointment on the Coetaneous Wound Healing in Cattle
Hr Moslemi , K Jamshidi , Mm Tavangar , K Kafshdouzan ,
year 11, Issue 42 (supplement 9 2012)
Abstract

Background: Wound and its management are the most common health problems in human and veterinary medicine. Herbal therapy is becoming increasingly popular among patients and physicians.

Objective: This study was conducted to evaluate the effects of 5% Urtica dioica ointment on full thickness wounds of nine cattle, were assessed by microscopic and macroscopic methods.

Methods: After preparing the operating site, a total of two full thickness skin wounds (3×4 cm) were created on the both sides of neck of each cattle. The wounds were treated by Urtica dioica , and saline solution twice daily. On days 5, 11 and 21 specimens was collected from wounds and evaluated histologically.

Results: Our study showed significant difference between treated and control groups, in wound contraction and epithelization on days 21. In group treated with Urtica dioica ointment, the healing process was higher than from control group. There is not any different between treated and control groups on days 5 and 11 significantly.

Conclusion: In conclusion, this study shows that the application of Urtica dioica increased the coetaneous wound healing in cattle.

Antibacterial Activity of Origanum vulgare on Staphylococcus aureus in a Rat Model of Surgical Wound Infection
M Rahmani Gohar , Hr Moslemi, Kh Kafshdouzan , R Mazaheri Nezhad Fard ,
year 15, Issue 57 (2-2016)
Abstract
Background: Wound infection is one of the frequent complications in patients with surgical operations. Staphylococcus aureus is the most common cause of surgical wound infections. Origanum vulgare, a common culinary herb, has been shown to have strong antimicrobial activity, especially against Gram-positive pathogens.
Objective: This study was designed to investigate the antibacterial effects of O. vulgare on S. aureus in surgical wounds using a rat model.
Methods: Twenty male Sprague-Dawley rats were divided randomly into two groups of treatment and control rats (1:1). A circular incision was made on the dorsal inter-scapular region of each rat. Then, rats were inoculated topically with 1 × 104 CFU of S. aureus at the site of skin wounds. O. vulgare extract was applied to wounds twice a day during the experiment. Animals of the control group were left untreated.
Results: The load of bacteria in untreated rats was 7 × 106 ± 6 CFU/wound while this was 2 × 105 ±1 CFU/wound for the treatment animals, which was significantly lower.
Conclusion: Results have showed that topical application of O. vulgare extract on the infected wounds included significant antibacterial activity against S. aureus.

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