Background: In recent years, plants natural products have gained considerable attention as natural preservers for use in different industries. Due to their free radical scavenging activities, phenolic compounds can prevent a wide range of diseases such as cancers and cardiovascular and neurodegenerative diseases. For a long time, different Ferulago species have been in use as medicinal plants worldwide.
 Objective: The aim of this research was to investigate total phenolics and the antioxidant and antibacterial activities of essential oil and different extracts from F. angulata growing wild in Iran.
 Methods: Antioxidant activity of our samples was examined by DPPH assay and their phenolic content was determined using the Folin – Ciocalteau method. Moreover, their inhibitory effects against five gram-negative and gram-positive bacteria including Shigella boidii, Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus and Enterococcus faecalis were tested by using the disk diffusion method.
 Results: Ethyl acetate fraction and methanol extract contained the highest levels of phenolic compounds (229.2 and 202.9 µg/mg galic acid) in this study. Also, essential oil of this plant exhibited low free radical scavenging activity (IC₅₀= 36129.43µg/ml). On the other hand, ethyl acetate and aqueous fractions had the highest antioxidant activity (IC₅₀ values of 20.153 and 28.28 µg/ml, respectively). Finally, studied samples had no significant antibacterial activities against tested organisms.
 Conclusion: The essential oil of this plant can be used as a flavoring agent while extracts prepared from it have the potential to be used as natural antioxidants in relevant industries.

Background: Hyperlipidemia is a heterogeneous group of disorders characterized by an excess of lipids in the bloodstream Objective: Given previous studies on barberry and Melissa officinalis extracts, this study aims at comparing hypolipidemic activities of Melissa officinalis extract and Berberis vulgaris. Methods: For the purpose of this study, 64 Wistar rats were selected and divided into 8 groups (n=8). The control group was administered with ordinary diet the sham group was administered with high-fat diet and intraperitoneally 0.2 ml/dl of the extract solvent (normal saline) and similarly, experimental groups received minimal, moderate and maximum dosages of barberry and Melissa officinalis extracts. The treatment group's was given high-fat diet for 21 days. After this period, blood samples were taken and the gathered data were analyzed using SPSS software. Results: The amount of cholesterol, triglyceride and LDL were increased in the model group compared to the control group, whereas the same substances were decreased significantly in the group receiving the extract compared to the model group (p<0.05). Conclusion: Hypolipidemic properties of alcohol extracts of Melissa officinalis are more effective than those of Berberis vulgaris. Moreover, it should be noted that it is rather the antioxidant properties of Melissa officinalis and their effects on the increase in thyroid hormones as well as the presence of alkaloid compounds, such as berberine in Berberis vulgaris, that inhibits cholesterol synthesis and enables its excretion.

Background: The People believe that herbal medicines are not toxic, but the toxicity of these drugs are reported to be seen. Objective: Therefore, the aim of this study was to evaluate hepatic and renal toxicity is Chelidonium majus hydroalcoholic extract. Methods: In this study, 35 male Wistar rats were divided into 5 groups (n=7), control group with normal diet and sham group with fat diet and experimental groups of animals hypercholesterolemia that received the minimum dose of 100, averaged 200 and maximum dose of 300 mg/kg hydroalcoholic extract Chelidonium majus (that collected from farms in the North of the country) by gavage. After this Period (21 days), blood samples were drawn and levels of liver alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline Phosphatase (ALP), albumin and total Protein as well as renal creatinine and blood urea nitrogen (BUN) were measured. The data obtained were analyzed using SPSS version 17. Results: The ALT was not seen any significant changes between the groups treated with the extract. AST, albumin, total Protein and creatinine increased, but the amount of ALP decreased significantly in high dose of extract. BUN in groups receiving the at least extract dose was not shown any significant changes compared to the control group but Cholesterol had a decreased significant changes at same dose compared to the control group (p<0.05). Conclusion: Since the amount of AST, albumin and creatinine extract the maximum dose is increased, especially at doses appear to extract Chelidonium majus have high toxic effects on the liver and kidneys.